A5036910021- Cervical Cancer and HPV Research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- NF-κB Signaling Pathways
- Cancer-related Molecular Pathways
- Polyomavirus and related diseases
- Inflammasome and immune disorders
- Genital Health and Disease
- Colorectal Cancer Screening and Detection
- Head and Neck Cancer Studies
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Immune Response and Inflammation
- Oral Health Pathology and Treatment
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
Khon Kaen University
2016-2023
MicroRNAs (miRNAs) are small non-coding RNAs that function to down-regulate gene expression involving in various cellular processes related carcinogenesis. Recently, miR-22 was identified as a tumor-suppressing miRNA many human cancers. However, the regulatory mechanism and specific of this cervical cancer remain unclear. In present study, we carried out transfection, western blot quantitative RT-PCR explore functional role cancer. We verified down-regulated tissues cell lines relative...
Recently, epidemiological evidence of high-risk human papillomavirus (hrHPV) and its association with the increasing risk esophageal cancer (EC) have been described. However, involvement such a virus in pathogenesis EC is still inconclusive literature. Therefore, our objective was to clarify epidemiology HPV infections primarily diagnosed cases validate this correlation hospital-based control patients using retrospective study case-control model. Here, we reported that overall prevalence DNA...
High risk human papillomavirus (HR-HPV) E2 proteins play roles in transcriptional regulation and are commonly functionally disrupted when the HPV genome integrates into host chromosomes. Some 15-40% of cancer cases, however, contain an intact gene or episomal HPV. In these polymorphism might be involved. This study aimed to determine polymorphisms HPV16 detected high grade squamous intraepithelial lesions cell carcinomas altered functions compared prototype. The was amplified sequenced. Two...
Deregulated expression of viral E6 and E7 genes often caused by genome integration high-risk human papillomaviruses (HR-HPVs) into host DNA additional genetic alterations are thought to be required for the development cervical cancer. However, approximately 15% invasive cancer specimens contain only episomal HPV genomes. In this study, we investigated tumorigenic potential keratinocytes harboring form HPV16 (HCK1T/16epi). We found that is sufficient promoting cell proliferation colony...
Prophylactic vaccines are already available for prevention of human papillomavirus (HPV) infection. However, we still await development therapeutic with high efficiency stimulating specific T lymphocytes to clear HPV infection.This study investigates the potential subunits p16INK4a protein and E2 HPV16 stimulate dendritic cells enhance response against HPV-infected cells.Immunogenic epitopes proteins were predicted through common HLA class I II alleles present in Thai population. Then,...