A5015513583- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Receptor Mechanisms and Signaling
- Pharmacogenetics and Drug Metabolism
- Mass Spectrometry Techniques and Applications
- Tracheal and airway disorders
- Environmental Toxicology and Ecotoxicology
- Marine Toxins and Detection Methods
- Neuroscience and Neuropharmacology Research
- bioluminescence and chemiluminescence research
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Pharmacological Effects and Assays
- Intergenerational Family Dynamics and Caregiving
- Per- and polyfluoroalkyl substances research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Advanced biosensing and bioanalysis techniques
- Melanoma and MAPK Pathways
- Lipid metabolism and biosynthesis
- Microbial bioremediation and biosurfactants
- Gender, Labor, and Family Dynamics
- DNA and Nucleic Acid Chemistry
- Pesticide and Herbicide Environmental Studies
- Assistive Technology in Communication and Mobility
Alfred I. duPont Hospital for Children
2018
Delaware Division of Public Health
2018
DuPont (United States)
2018
University of Michigan
2003
University of California, Davis
1992-1998
University of California System
1996
Michigan State University
1988-1993
Indiana University – Purdue University Indianapolis
1993
California Department of Toxic Substances Control
1992
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions variety hydrophobic natural synthetic chemicals, including environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin). A indole-containing such as indole-3-carbinol, indolo[3,2-b]carbazole, UV photoproducts tryptophan (TRP), have previously been identified ligands for AhR. Here we examined ability endogenous metabolites (TRP) to bind...
2,3,7,8,-Tetrachlorodibenzo-p-dioxin (TCDD) administered in vivo causes drastic reduction the weight of mouse thymus at low doses (e.g., 30 micrograms/kg single i.p. injection), becoming statistically significant after 2 days. To understand cause for such thymic involution TCDD-evoked changes various biochemical parameters this tissue were examined. The most noticeable change was observed increased activity specific protein-tyrosine kinases and protein kinase C an level p21ras-associated...
Newborn screening for cystic fibrosis (CF) has been universal in the US since 2010; however, there is significant variation among newborn algorithms. Systematic reviews were used to develop seven recommendations program practices improve timeliness, sensitivity, and equity diagnosing infants with CF: (1) The CF Foundation recommends use of a floating immunoreactive trypsinogen (IRT) cutoff over fixed IRT cutoff; (2) using very high referral strategy programs whose variant panel does not...
Sexually dimorphic expression of a broad array liver proteins involved in reproduction and xenobiotic metabolism is induced at puberty by sex-specific growth hormone patterns. An additional control sex-dependent gene conferred Regulator sex-limitation ( Rsl ) alleles. In variant rsl mice, females inappropriately express the male Sex-limited protein, Slp. We recently showed that panel male-specific genes repressed , accentuating sex differences hormone-independent manner. Here we map to...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinding of transformed Ah receptor complex to a dioxin responsive transcriptional enhancer: Evidence for two distinct heteromeric DNA-binding formsHollie I. Swanson, Kathryn Tullis, and Michael S. DenisonCite this: Biochemistry 1993, 32, 47, 12841–12849Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November...
Expression of a broad array proteins is sexually dimorphic in rodent liver, dependent on sex-specific patterns GH secretion. Mice carrying rsl (regulator sex limitation) alleles, discovered as trans-acting loci affecting the mouse sex-limited protein (Slp) gene, reveal an additional axis male-specific gene regulation. Slp expresses adult males, but homozygous mice, also expressed females. In this study, we examined congenic strains to determine rsl's site action, breadth targets, and...
Conventional chemical analyses of incineration by-products identify compounds known toxicity but often fail to indicate the presence other chemicals that may pose health risks. In a previous report, extracts from soot aerosols formed during incomplete combustion trichloroethylene (TCE) and pyrolysis plastics exhibited dioxinlike response when subjected keratinocyte assay. To verify this effect, complete extract, its polar nonpolar fractions, some containing primarily halogenated aromatic...
Brevetoxins (PbTx) are a family of marine polyether toxins that exert their toxic action by activating voltage-sensitive sodium channels. Two forms brevetoxin, PbTx-2 and -3, induce hepatic cytochrome P4501A1, measured as ethoxyresorufinO-deethylase (EROD) activity, in redfish striped bass. P4501A1 induction is transcriptionally regulated through the binding ligand, typically planar aromatic compound, to aryl hydrocarbon receptor (AhR) subsequent complex formation with dioxin response...
Exposure to specific polychlorinated diaromatic hydrocarbons (PCDH), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), produces a wide variety of species- and tissue-specific toxic biological effects. Many these responses are mediated by the Ah receptor (AhR) modulated interaction PCDH:AhR complex with its DNA recognition sequence (the dioxin-responsive element (DRE)). We have constructed recombinant expression plasmid which contains luciferase gene under TCDD-inducible control...
Abstract A series of in vivo and vitro experiments were conducted to determine the effects 2, 3, 7, 8‐tetrachlorodibenzo‐p‐dioxin (TCDD) administered on expression c‐ ras. Differences ras between control TCDD treated groups determined by immunoassay p21 protein, or indirectly measured specific binding 3 H‐GTP hepatic plasma membrane preparations. Intraperitoneal injection sublethal doses significantly elevated (P < 0.05, Student t test) levels protein Sprague‐Dawley rats sensitive...