A5035868288- Ophthalmology and Eye Disorders
- Vestibular and auditory disorders
- Cerebral Venous Sinus Thrombosis
- Glaucoma and retinal disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Myasthenia Gravis and Thymoma
- Visual perception and processing mechanisms
- Sympathectomy and Hyperhidrosis Treatments
- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Migraine and Headache Studies
- Parkinson's Disease and Spinal Disorders
- Parkinson's Disease Mechanisms and Treatments
- Retinal Development and Disorders
- Meningioma and schwannoma management
- Autoimmune Neurological Disorders and Treatments
- Multiple Sclerosis Research Studies
- Hemispheric Asymmetry in Neuroscience
- Retinal Diseases and Treatments
- Hereditary Neurological Disorders
- Olfactory and Sensory Function Studies
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Intracranial Aneurysms: Treatment and Complications
- Neutropenia and Cancer Infections
University Hospital of Zurich
2015-2024
University of Zurich
2015-2024
Royal Prince Alfred Hospital
2007-2024
The University of Sydney
2008-2024
Center for Pediatric Endocrinology Zurich
2021-2022
Schulthess-Klinik
2015-2021
Kantonsspital Baden
2020
Leiden University Medical Center
2020
University Children's Hospital Zurich
2018
Medical University of Vienna
2017
The head impulse test (HIT) is a useful bedside to identify peripheral vestibular deficits. However, such deficit of the vestibulo-ocular reflex (VOR) may not be diagnosed because corrective saccades cannot always detected by simple observation. scleral search coil technique gold standard for HIT measurements, but it practical routine testing or acute patients, they are required wear an uncomfortable contact lens.
Quantitative head impulse test (HIT) measures the gain of angular vestibulo-ocular reflex (VOR) during rotation as ratio eye to acceleration. Bedside HIT identifies subsequent catch-up saccades after indirect signs VOR deficit.To determine deficit and saccade characteristics in unilateral vestibular disease response varying accelerations.Eye rotations were measured with search coils manually applied horizontal HITs accelerations patients neuritis (VN, n = 13) deafferentation (UVD, 15)...
Background/Hypothesis. The video Head Impulse Test (vHIT) is now widely used to test the function of each six semicircular canals individually by measuring eye rotation response an abrupt head in plane canal. main measure canal adequacy ratio movement stimulus i.e. gain vestibulo-ocular reflex (VOR). However there a need for normative data about how VOR affected age and also velocity, allow any particular patient be compared healthy subjects their range. In this study we determined all...
Background The video head impulse test (vHIT) is a useful clinical tool to detect semicircular canal dysfunction. However vHIT has hitherto been limited measurement of horizontal canals, while scleral search coils have the only accepted method measure impulses in vertical canals. goal this study was determine whether can dysfunction as identified by coil recordings. Methods Small unpredictable rotations were delivered hand diagonally plane canals gaze directed along same plane. planes...
Objective The video head impulse test (vHIT) is a useful clinical tool to detect semicircular canal dysfunction. However, so far, vHIT has been limited measurement of the function horizontal canals. goal this study was determine if can vertical Study Design Horizontal and eye movements were recorded in response abrupt, passive, unpredictable turns (head impulses) planes canals by high-speed (250-Hz sampling rate) together with measures movement. Head impulses delivered diagonally plane...
Motor unit activity in human eye muscles during the vestibulo-ocular reflex (VOR) is not well understood, since associated head and movements normally preclude single recordings. Therefore we recorded motor following bursts of skull vibration sound, two vestibular otolith stimuli that elicit only small movements. Inferior oblique (IO) inferior rectus (IR) muscle was measured healthy humans with concentric needle electrodes. Vibration elicited highly synchronous, short-latency IO (latency:...
While compensatory saccades indicate vestibular loss in the conventional head impulse test paradigm (HIMP), which participant fixates an earth-fixed target, we investigated a complementary suppression (SHIMP), is fixating head-fixed target to elicit anticompensatory as sign of function.HIMP and SHIMP eye movement responses were measured with horizontal video patients unilateral loss, bilateral healthy controls.Vestibulo-ocular reflex gains showed close correlation (R(2) = 0.97) slightly...
Parenteral antibiotic therapy with gentamicin, even in accepted therapeutic doses, can occasionally cause bilateral vestibular loss (BVL) due to hair cell toxicity.To quantify patients gentamicin vestibulotoxicity (GVT) the extent of acceleration gain deficit horizontal vestibulo-ocular reflex at different accelerations a graded head impulse test (HIT) comparison standard caloric and rotational testing. To characterize corresponding HIT catch-up saccade pattern provide basis for its salience...
Bilateral vestibular loss (BVL) may present with or without vertigo and hearing loss. Amongst the causes of BVL are vestibulotoxic antibiotics, autoimmune ear diseases, Menière's disease meningitis. Clinical diagnosis is based on result three simple bedside tests: a positive head impulse test, reduced dynamic visual acuity Romberg test foam rubber. With these signs, severe usually straightforward to establish.
Objective: Rotational vestibular function declines with age resulting in saccades as a compensatory mechanism to improve impaired gaze stability. Small reductions rotational vestibulo-ocular reflex (VOR) gain that would be considered clinically normal have been associated saccades. We evaluated whether saccade characteristics varied of age, independent semicircular canal quantified by VOR gain. Methods: Horizontal was measured 243 participants 27-93 from the Baltimore Longitudinal Study...
Objective. Visual snow (VS) is a distressing, life-impacting condition with persistent visual phenomena. patients show cerebral hypermetabolism within the cortex, resulting in altered neuronal excitability. We hypothesized to see disease-dependent alterations functional connectivity and grey matter volume regions associated perception. Methods. 19 VS 16 sex age-matched controls were recruited. Functional magnetic resonance imaging (fMRI) was applied examine resting-state (rsFC). Volume...
Electrical vestibular stimulation is believed to directly activate the afferents mediate an electrically evoked vestibulo-ocular reflex (eVOR). Gentamicin, aminoglycoside antibiotic, induces vestibulotoxicity by hair cell damage and death.To determine if human eVOR impaired death in systemic gentamicin (GV).Three-dimensional binocular eye movements bilateral, bipolar, 100 msec direct current-step at intensities of 0.9, 2.5, 5.0, 7.5, 10.0 mA were recorded with dual-search coils 12 GV...
<h3>Objective:</h3> To explore whether ocular vestibular evoked myogenic potentials (oVEMP) can be used to detect a decrement in the extraocular muscle activity of patients with myasthenia gravis (MG). <h3>Methods:</h3> Twenty-seven MG, including 13 isolated and 14 generalized 28 healthy controls participated. We applied repetitive vibration stimuli forehead recorded inferior oblique 2 surface electrodes placed beneath eyes. identify oVEMP parameters highest sensitivity specificity, we...
Background: Although fluctuating muscular weakness is the hallmark of myasthenia gravis (MG), research into it, especially during course day, remains limited. Understanding dynamics myasthenic symptoms essential for diagnosis and anticipatory treatment. Therefore, in this study, we used orthoptic other established quantitative subjective methods to measure ocular (OMG) throughout 2 months, response Methods: The goal study was determine change gaze deviation ptosis over 1 hour after...
Objective: Diagnosing ocular myasthenia gravis (OMG) remains challenging despite recent diagnostic advances. We addressed this challenge by developing and validating a multivariable prediction model that estimates the OMG probability given results of any partial selection available tests. Methods: The source data for our were retrieved from blinded prospective accuracy study at University Hospital Zurich (USZ). Patients with ptosis and/or diplopia whose presentation was suspicious underwent...