Breast cancer is the second leading cause of death worldwide. Nanotechnology approaches can overcome side effects chemotherapy as well improve efficacy drugs. Dendrimers are nanometric size polymers which suitable drug delivery systems. To best our knowledge, studies on application PAMAM G4.5 (polyamidoamine half generation 4) dendrimers potential systems in breast have not been reported. In this work we developed a dendrimer containing FITC (fluorescein isothiocyanate) dye to study their...

The overall results presented in this work indicate the potential use of ICG-loaded PEO–PPO PMs as image probe agents to be employed image-guided surgery, sentinel lymph node biopsy and breast cancer diagnostic imaging.

This study compares two methods for extracting nanocellulose from pineapple agro-waste: chemical hydrolysis using sulfuric acid, and bacterial biosynthesis via Rhizobium leguminosarum biovar trifolii. SEM, FTIR, AFM characterized produced by both routes. A multi-criteria decision matrix was used to evaluate process efficiency, environmental impact, operational complexity. The route showed advantages in water footprint (0.3 L vs. 14 L), purification simplicity (~2 steps ~5), waste safety...

Abstract This work investigates the potential of glycosylation to actively target nanodrug delivery systems adult solid tumors overexpressing glucose transporters. The highly hydrophobic fluorescent compound curcumin (CUR) is nanoencapsulated within polymeric micelles pristine and glucosylated poly(ethylene oxide)‐poly(propylene oxide) block copolymers, their interaction with breast cancer (BC) cells investigated in vitro vivo. aqueous solubility CUR increased more than 50 000‐fold spherical...

Background: Carboranylanilinoquinazoline-hybrids, developed for boron neutron capture therapy, have demonstrated cytotoxicity against murine-glioma cells with EGFR-inhibition ability. In addition, their adequate aqueous/metabolic stabilities and ability to cross blood–brain barrier make them good leads as become antiglioma drugs. Aim: Analyze drug-like properties of representative carboranylanilinoquinazolines. Materials & methods: To expand carboranylanilinoquinazolines therapeutic...

This study reviews the many uses for waste generated from acerola (Malpighia spp.) production, a tropical fruit renowned its nutrient-rich content. Traditionally considered an environmental burden, this is now gaining attention sustainable applications in green technology. review outlines extraction of valuable bioactive compounds, like polyphenols, carotenoids, and pectin, that can be extracted waste, it also delves into potential materials science, particularly creation pharmaceutical...

Abstract 7‐Fluoro‐2‐aminophenazine 5,10‐dioxide, 1 , has displayed in vitro bioreductive selective cytotoxicity, which could acts towards tumors containing hypoxic regions. In this work, we describe some preclinical studies of compound confirming its vivo antitumor activity. The synthesis was scaled up to 3 g improving the micro‐scale yield. Some drug‐like properties for were theoretically‐predicted and others, i. e. aqueous‐solubility toxicity ‐mutagenicity, chromosomal‐aberrations ip acute...

Acerola (Malpighia spp.) is a tropical plant genus of shrubs and trees whose fruit rich in nutrients bioactive compounds. However, its production generates significant waste that could pose an environmental issue. This review aims to summarize recent research on the potential uses acerola wastes, including extraction compounds such as polyphenols, carotenoids, pectins, well development materials nanomaterials, chitosan, biofuels. Additionally, paper discusses medical applications wound...

The objective of this work was to formulate PVA films with the addition modified phenols, chitosan, silver, or copper nanoparticles fungistatic and bacteriostatic activity. were characterized by Fourier transform infrared spectroscopy, thermogravimetry analysis, differential scanning calorimetry, electron microscopy. activity against Salmonella gallinarum Lactobacillus acidophilus, Penicillium acidophilus determined. results indicated that phenols enhanced effect on stability chemical...

2-Amino-7-fluorophenazine 5,10-dioxide (FNZ) is a bioreducible prodrug, poorly soluble in water, with potential anticancer activity on hypoxic-tumors. This poor solubility limits its applications clinic. Amphiphilic pristine polymeric micelles (PMs) based triblock copolymers Pluronic® and Tetronic®, glycosylated derivatives their mixtures preformed-liposomes (LPS), were analyzed as strategies to improve the bioavailability of FNZ. FNZ encapsulations performed obtaining nanostructures...

Purpose: To study surface technetium labeling of stealth DTPA-Liposomeand to evaluate its potential as a molecular imaging tracer for both normal and melanoma-bearing mice. The radiolabeling yield liposomes was greater than 90%and showed good chemical biological stability. Biodistribution studies in mice blood clearance with hepatic renal depuration. Melanoma-bearing similar pattern biodistribution high tumor uptake allowing imaging. developed method radiolabeled DTPA-PEG-Liposomes 99mTc...

The biomass industrialization valorisation of grains and cereals is considered an opportunity for the countries where agro-industrial activity one its main economic activities, rendering new higher-value products with a concomitant solution to waste accumulation issues. To that end, in this work we describe characterise bioactive compounds generation from rice husk by semi-solid fermentation, obtained 500 g material at room temperature 60% humidity mixed cultures Phanerochaete chrysosporium...

Existe una amplia gama de prácticas relacionadas con el uso recursos educativos en cursos modalidad semipresencial y a distancia. Las tecnologías la información comunicación han permitido incorporar variados enfoques fin generar enseñanza mejor calidad. En este trabajo se resume nueva experiencia aplicada un curso universitario masivo Química. Inicialmente dictado presencial, incorporó importantes cambios organizacionales junto entorno virtual aprendizaje, distribuyendo los estudiantes...

In recent years, nanocarriers have been studied as promising pharmaceutical tools for controlled drug-delivery, treatment-efficacy follow-up and disease imaging. Among them, X-shaped amphiphilic polymeric micelles (Tetronic®, poloxamines) display great potential due to their biocompatibility non-toxic effects, among others. the present work, based on T1307 copolymer were initially decorated with a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-fluorophore in order determinate its vivo...

Acerola (Malpighia spp.) is a tropical plant genus of shrubs and trees whose fruit rich in nutrients bioactive compounds. However, its production generates significant waste that could pose an environmental issue. This review aims to summarize recent research on the potential uses acerola wastes, including extraction compounds such as polyphenols, carotenoids, pectins, well development materials nanomaterials, chitosan, biofuels. Additionally, paper discusses medical applications wound...

Curcumin is a natural polyphenol molecule derived from the plant Curcuma longa that exhibits anticancer, antifungal, antiviral, antioxidative, anti-inflammatory and antiploriferative properties.  widely available in world, safe, inexpensive has multiple cancer-fighting functions justify its development as drug for cancer treatment. However, several basic clinical studies have elucidated limited efficacy due to low solubility, high metabolism rate bioavailability.  In order target...

Breast cancer is a solid tumor characterized by high level of hypoxic areas which are difficult to treat. The rate this disease in women elevated, mainly developing countries since the diagnosis made later stages disease. We have developed bioreductive prodrugs under conditions hypoxia compound 2-amino-7(8)-fluorophenazine N 5 ,N 10 - dioxide (FNZ) stands out as potent and selective anticancer agent. In order improve ADME properties FNZ was vehiculated physiological serum:tween (PS:T). This...

Our group has previously reported potential new radiopharmaceuticals, i.e. 99m Tc-tricarbonyl-(2-amino- 5,10-dioxide- 7(8)-fluorophenazine), Tc-FZ), with the ability to detect hypoxic tumoral tissues. Previously, this probe was used solid tumors, employing a model of lung carcinoma generated by inoculation 3LL Lewis murine cells in C57BL/6 mice. The resultsrevealed an adequate tumor/muscle ratio, 3.8 at 2 h post-injection (p.i.), lower tumor/blood 0.6 p.i.. Due some models breast cancer also...