A5046521612- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Protein Structure and Dynamics
- Insect symbiosis and bacterial influences
- Evolution and Genetic Dynamics
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Enzyme Production and Characterization
- Enzyme Structure and Function
University of Cologne
2017
University of Copenhagen
2016
New Mexico State University
2016
Reassortment, which is the exchange of genome sequence between viruses co-infecting a host cell, plays an important role in evolution segmented viruses. In human influenza virus, reassortment happens most frequently co-existing variants within same lineage. This process breaks genetic linkage and fitness correlations viral segments, but resulting net effect on has remained unclear. this paper, we determine rate average selective processes lineage A/H3N2. For surface proteins hemagglutinin...
Charges are considered an integral part of protein structure and function, enhancing solubility providing specificity in molecular interactions. We wished to investigate whether charged amino acids indeed required for biogenesis a completely free titratable side chains can maintain solubility, stability, function. As model, we used cellulose-binding domain from Cellulomonas fimi, which, among proteins more than 100 acids, presently is the least Protein Data Bank, with total only four...
Each of the four serotypes mosquito-borne dengue virus (DENV-1-4) comprises multiple, genetically distinct strains. Competitive displacement between strains within a serotype is common feature DENV epidemiology and can trigger outbreaks disease. We investigated mechanisms underlying two sequential displacements by DENV-3 in Sri Lanka that each coincided with abrupt increases haemorrhagic fever (DHF) incidence. First, post-DHF strain displaced pre-DHF 1980s. have previously shown more...