A5046538271- Gut microbiota and health
- Metabolism, Diabetes, and Cancer
- Genetic Associations and Epidemiology
- Clostridium difficile and Clostridium perfringens research
- Epigenetics and DNA Methylation
- SARS-CoV-2 detection and testing
- Diet and metabolism studies
- MicroRNA in disease regulation
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Circular RNAs in diseases
- Rheumatoid Arthritis Research and Therapies
- Extracellular vesicles in disease
- Spondyloarthritis Studies and Treatments
- Alcohol Consumption and Health Effects
- RNA modifications and cancer
- Tryptophan and brain disorders
- Digestive system and related health
- Systemic Lupus Erythematosus Research
- Bioinformatics and Genomic Networks
- Liver Disease Diagnosis and Treatment
Latvian Biomedical Research and Study Centre
2018-2025
The gut microbiome plays a pivotal role in the modulation of host responses during viral infections, and recent studies have underscored its significance context coronavirus disease 2019 (COVID-19). We aimed to investigate dynamics compositional changes COVID-19 patients, addressing both acute phase recovery process, with particular focus on emergence post-COVID-19 conditions. Involving 146 patients 110 healthy controls, this study employed shotgun metagenomics approach for cross-sectional...
Effects of metformin, the first-line drug for type 2 diabetes therapy, on gut microbiome composition in have been described various studies both human subjects and animals. However, details molecular mechanisms metformin action not fully understood. Moreover, there is a significant lack information how affects female mouse models, depending sex metabolic status well controlled experimental setting. Our study aimed to examine metformin-induced alterations diversity, composition, functional...
The study was conducted to investigate the effects of metformin treatment on human gut microbiome's taxonomic and functional profile in Latvian population, evaluate correlation these changes with therapeutic efficacy tolerance.In this longitudinal observational study, stool samples for shotgun metagenomic sequencing-based analysis were collected two cohorts. first cohort included 35 healthy nondiabetic individuals (metformin dose 2x850mg/day) at three time-points during administration....
The gut microbiome composition is intricately linked to the host’s health status, yet mechanisms underlying its interaction with host are not fully understood. MicroRNAs (miRNAs), facilitating intercellular communication, found in bodily fluids, including intestinal content, where they may affect microbiome. However, their role type 2 diabetes (T2D)-associated and treatment implications explored. Our study investigated how miRNAs influence changes related metformin a T2D mouse model....
Increasing evidence suggests that regular physical exercise not only reduces the risk of cancer but also improves functional capacity, treatment efficacy and disease outcome in patients. At least partially, these effects are mediated by secretome tissues responding to exercise. The secreted molecules can be released a carrier-free form or enclosed into extracellular vesicles (EVs). Several recent studies have shown EVs actively circulation during Here, we for first time investigated...
Antidiabetic drug metformin alters the gut microbiome composition in context of type 2 diabetes and other diseases; however, its effects have been mainly studied using fecal samples, which offer limited information about intestinal site-specific this drug. Our study aimed to characterize spatial variation response treatment by a high-fat diet-induced mouse model both sexes. Four parts, each at luminal mucosal layer level, were analyzed performing 16S rRNA sequencing covering six variable...
Abstract Background Type 2 diabetes complications cause a serious emotional and economical burden to patients healthcare systems globally. Management of both acute chronic diabetes, which dramatically impair the quality patients' life, is still an unsolved issue in care, suggesting need for early identification individuals with high risk developing complications. Methods We performed genome-wide association study 601 type after stratifying them according presence or absence four types...
Metformin, a biguanide agent, is the first-line treatment for type 2 diabetes mellitus due to its glucose-lowering effect. Despite wide application in of multiple health conditions, glycemic response metformin highly variable, emphasizing need reliable biomarkers. We chose RNA-Seq-based comparative transcriptomics approach evaluate systemic effect and highlight potential predictive biomarkers drug-naïve volunteers with vivo. The longitudinal blood-derived transcriptome analysis revealed...
Introduction Research findings of the past decade have highlighted gut as main site action oral antihyperglycemic agent metformin despite its pharmacological role in liver. Extensive evidence supports metformin’s modulatory effect on composition and function microbiota, nevertheless, underlying mechanisms host responses remain elusive. Our study aimed to evaluate metformin-induced alterations intestinal transcriptome profiles at different metabolic states. Methods The high-fat diet-induced...
Remaining a major healthcare concern with nearly 29 million confirmed cases worldwide at the time of writing, novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused more than 920 thousand deaths since its outbreak in China, December 2019. First case person testing positive for SARS-CoV-2 infection within territory Republic Latvia was registered on 2nd March 2020, 9 days prior to pandemic declaration by WHO. Since then, 277,000 tests were carried out confirming total...
Abstract Effects of metformin, the first-line drug for type 2 diabetes therapy, on gut microbiome composition in have been described various studies both human subjects and animals. However, details molecular mechanisms metformin action not fully understood. Moreover, there is a significant lack information how affects female mice models, as most existing focused males only. Our study aimed to examine metformin-induced alterations diversity high-fat diet-induced mouse model, employing...
CD40 gene rs4810485 polymorphism was tested by a TaqMan Pre-Designed SNP Genotyping Assay.In the case of polymorphism, minor allele is T. Compared to control subjects, group had higher frequency T (28.6% vs. 17.5%;p=0.00345).The risk for disease onset (OR 1.88 (95% CI 1.23-2.88)).The relationship between and genotypes moderate significance (V=0.20).As genotypes, GT TT were susceptibility AS (respectively OR 2.42 1.38 -4.25) 1.94 0.71-5.32)).The GG genotype protective feature 0.43 0.25...
Abstract Remaining a major healthcare concern with nearly 29 million confirmed cases worldwide at the time of writing, novel severe acute respiratory syndrome coronavirus - 2 (SARS-CoV-2) has caused more than 920 thousand deaths since its outbreak in China, December 2019. First case person testing positive for SARS-CoV-2 infection within territory Republic Latvia was registered on nd March 2020, nine days prior to pandemic declaration by WHO. Since then, 277 000 tests were carried out...