A5082059565- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Synthesis of heterocyclic compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Heterocycles
- Asymmetric Synthesis and Catalysis
- Coordination Chemistry and Organometallics
- Chemical Synthesis and Reactions
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Analysis
- Oxidative Organic Chemistry Reactions
- Chemical Reaction Mechanisms
- Crystallography and molecular interactions
- Bioactive Compounds and Antitumor Agents
- Reproductive biology and impacts on aquatic species
- Aquaculture Nutrition and Growth
- Fluorine in Organic Chemistry
- Inorganic and Organometallic Chemistry
- Hormonal and reproductive studies
- Organoselenium and organotellurium chemistry
- Synthesis and Catalytic Reactions
- Computational Drug Discovery Methods
- Microbial Metabolism and Applications
- Organic Chemistry Synthesis Methods
Instituto Politécnico Nacional
2004-2018
Tecnológico Nacional de México
2012
National Commission for the Knowledge and Use of Biodiversity
2007
Universidad Nacional Autónoma de México
1999
Princeton University
1985
University of East Anglia
1980
Abstract Background Imidazo[1,2-a]pyridines and pyrimidines are important organic fluorophores which have been investigated as biomarkers photochemical sensors. The effect on the luminescent property by substituents in heterocycle phenyl rings, studied well. In this investigation, series of 3-hydroxymethyl imidazo[1,2-a]pyridines were synthesized evaluated relation to fluorescence emission, based upon hypothesis that hydroxymethyl group may act an enhancer intensity. Results Compounds both...
To counteract bacterial resistance, we investigated the interruption of quorum sensing mediated by non-classical bioisosteres N-hexanoyl homoserine lactone with an azoline core. For this purpose, a set selected 2-substituted azolines was synthesized, establishing basis for new protocol to synthesize 2-amino imidazolines. The synthesized compounds were evaluated as inhibitors violacein production in Chromobacterium violaceum. Theoretical studies on bioisostere-protein interactions performed...
Abstract Three imidazo[1,2‐ a ]pyridine‐3‐nitrosated (L‐1, L‐2, L‐3) and 3‐formyl ]pyridine thiosemicarbazone (L‐4) were synthesized evaluated for their effects in the elevated plus maze, burying behavior test, rotarod performance, horizontal wire locomotor activity. L‐2 L‐3 increased percent time spent open arms of maze at doses 1 2 mg/kg without modifying number total entries. In addition, (1 mg/kg) arm entries indicating anxiolytic‐like activity this dose. behavioral L‐1 (2–8 mg/kg), (8...
A series of four different armed heterocyclic candidates; 1-(2-methyl-2,3-dihydro-1,3-benzothiazol-2-yl)acetone (2), 1-(3-methyl-4H-1,4-benzothiazin-2-yl)ethanone (3), 2-[(2-aminophenyl)dithio]aniline (4), and 3-hydroxy-3-methyl-4-(3-methyl-2-quinoxalinyl)-2-butanone (5) have been prepared their microbial activities were evaluated. correlation the structure relationships these compounds with respect to molecular modeling, Lipinski Rule Five, drug likeness, toxicity profiles, other...
Elimination of the hydroxylamino portion in arylhydroximoyl chlorides upon nucleophilic addition ethylenediamine rendered an alternative procedure for 2-arylimidazolines preparation.The imidazole nucleus, its various oxidation states has shown to be oustanding source compounds which possess therapeutic value.' 2-Imidazolines on their own are often associated with drugs acting as adrenergic agenW2 The 2-imidazoline nucleus is available from interaction diamines carboxylic acids,...
A series of selected 2-substituted imidazolines were synthesized in moderate to excellent yields by a modification protocols reported the literature. They evaluated as potential non-classical bioisosteres AHL with aim counteracting bacterial pathogenicity. Imidazolines 18a, 18e and 18f at various concentrations reduced violacein production Chromobacterium violaceum, suggesting an anti-quorum sensing profile against Gram-negative bacteria. Imidazoline 18b did not affect violacein, but had...
5-Methyl-2-(pyridin-3-yl)-4,5-dihydrooxazole and 5-methyl-2-(pyridin-4-yl)-4,5-dihydrooxazole activated by triflic anhydride underwent lactonization with bis(trimethylsilyl)ketene acetals to provide tetrahydrooxino[3,4-<i>c</i>]pyridines tetrahydrofuro[3,2-<i>b</i>]pyridin-2-ones. Formation of the product was controlled position pyridyl substituent at C-3 C-4 pyridyldihydrooxazole. On other hand, 1-(trifluoromethylsulfonamido)propan-2-yl picolinate obtained under same conditions from...
Abstract The imidazo[1,2‐ a ]pyridine system was investigated as synthon for the building of very attractive fused triazines, planar, angular tri ‐heterocycle with potential biological activity. Thus ethyl 3‐nitroimidazo[1,2‐ ]pyridine‐2‐carboxylate treated ammonia or an excess primary amines to generate corresponding substituted nitro carboxamidoimidazopyridines. substituent in latter products, reduced yield 3‐amino‐2‐carboxamidoimidazo[1,2‐ derivatives, which turn were nitrous acid furnish...
Article SYNTHESIS OF ENAMINONITRILE IMIDAZO[l. 2-a]PYRIDINE BY AN EHRLICHSACHS TYPE REACTION ON 2-NITROSOPYRIDINE was published on October 1, 2006 in the journal Heterocyclic Communications (volume 12, issue 5).