A5041290896- Opioid Use Disorder Treatment
- HIV, Drug Use, Sexual Risk
- Substance Abuse Treatment and Outcomes
- HIV/AIDS Research and Interventions
- Prenatal Substance Exposure Effects
- Cannabis and Cannabinoid Research
- HIV Research and Treatment
- Forensic Toxicology and Drug Analysis
- Pain Management and Opioid Use
- Sex work and related issues
- Hepatitis C virus research
- Homelessness and Social Issues
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- HIV-related health complications and treatments
- Treatment of Major Depression
- LGBTQ Health, Identity, and Policy
- Psychedelics and Drug Studies
- Health Systems, Economic Evaluations, Quality of Life
- T-cell and B-cell Immunology
- Pneumocystis jirovecii pneumonia detection and treatment
- Poisoning and overdose treatments
- Pharmaceutical Practices and Patient Outcomes
- Healthcare Policy and Management
- Ethics in Clinical Research
British Columbia Centre on Substance Use
2017-2025
University of British Columbia
2016-2025
St. Paul's Hospital
2016-2025
Dà-Jiāng Innovations Science and Technology (China)
2022-2024
British Lung Foundation
2022-2024
Multi Electrical System (Suriname)
2019-2024
St. Paul's Co-educational College
2020-2024
Fundación Huésped
2011-2023
Novem (Netherlands)
2023
Government of British Columbia
2022
Transgender (TG) women in many settings continue to contend with barriers healthcare, including experiences of stigma and discrimination. Argentina has a universal health care system laws designed promote healthcare access among TG women. However, little is known about this setting. The aim study was explore individual, social-structural environmental factors associated avoidance Argentina. Data were derived from 2013 nation-wide, cross-sectional involving We assessed the prevalence avoiding...
Background Background: In response to the COVID-19 pandemic, US Substance Abuse and Mental Health Services Administration (SAMHSA) allowed for an increase in methadone take-home doses treatment of Opioid Use Disorder (OUD) March 2020.
Abstract Background and Aims The ‘cascade of care’ framework, measuring attrition at various stages care engagement, has been proposed to guide the public health response opioid overdose emergency in British Columbia, Canada. We estimated cascade for use disorder identified factors associated with engagement people (PWOUD) provincially. Design Retrospective study using a provincial‐level linkage four administrative databases. Setting participants All PWOUD BC from 1 January 1996 30 November...
Objective: Extensive exposure to prescription-type opioids has resulted in major harm worldwide, calling for better-adapted approaches opioid agonist therapy. The authors aimed determine whether flexible take-home buprenorphine/naloxone is as effective supervised methadone reducing use consumers with disorder. Methods: This seven-site, pan-Canadian, 24-week, pragmatic, open-label, noninferiority, two-arm parallel randomized controlled trial involved treatment-seeking adults Participants were...
Abstract Background & Aims Despite the high burden of hepatitis C virus (HCV) infection among people who inject drugs (PWID), uptake interferon‐based therapies has been extremely low. Increasing availability direct‐acting antiviral (DAA)‐based offers possibility rapid treatment expansion with goal controlling HCV epidemic. We evaluated DAA‐based HCV‐positive PWID in Vancouver after introduction DAAs government drug formulary. Methods Using data from three cohorts Vancouver, Canada, we...
Abstract Background and Aims Cannabis use is common among people on opioid agonist treatment (OAT), causing concern for some care providers. However, there limited conflicting evidence the impact of cannabis OAT outcomes. Given critical role retention in reducing opioid‐related morbidity mortality, we aimed to estimate association at least daily likelihood initiating OAT. As a secondary aim tested impacts less frequent use. Design Data were drawn from two community‐recruited prospective...
Importance Previous studies on the comparative effectiveness between buprenorphine and methadone provided limited evidence differences in treatment effects across key subgroups were drawn from populations who use primarily heroin or prescription opioids, although fentanyl is increasing North America. Objective To assess risk of discontinuation mortality among individuals receiving buprenorphine/naloxone vs for opioid disorder. Design, Setting, Participants Population-based retrospective...
This study examined the lifetime prevalence and correlates of attempted suicide among transgender persons in Argentina. Data were derived from a nation-wide, cross-sectional survey conducted 2013. We assessed individual, social, structural reporting history attempting using logistic regression. Among 482 participants, median age was 30, 91% identified as transwomen, 32% resided Buenos Aires metropolitan area. A attempt reported by 159 (33%), whom at first 17. In multivariate model,...
Abstract The aim of this study was to analyze Th17 and Treg subsets their correlation with anti-HIV T-cell responses clinical parameters during (acute/early) primary HIV infection (PHI) up one year post-infection (p.i). Samples from 14 healthy donors (HDs), 40 PHI patients, 17 Chronics 13 Elite controllers (ECs) were studied. percentages severely altered in Chronics, whereas all HIV-infected individuals (including ECs) showed Th17/Treg imbalance compared HDs, concordance higher frequencies...