A5003501310- Genomics and Chromatin Dynamics
- Viral Infections and Immunology Research
- Cancer Genomics and Diagnostics
- CRISPR and Genetic Engineering
- interferon and immune responses
- Epigenetics and DNA Methylation
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- RNA Research and Splicing
Van Andel Institute
2023-2025
Case Western Reserve University
2023
Howard Hughes Medical Institute
1990
University of Chicago
1990
Journal Article Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4 Get access L.H. Philipson, Philipson Departments Medicine, Biochemistry and Molecular Biology The Howard Hughes Medical Institute, University ChicagoChicago, IL, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar K. Schaefer, Schaefer J. LaMendola, LaMendola G.I. Bell, Bell D.F. Steiner Nucleic Acids Research, Volume 18, Issue 23, 1 December 1990, Page 7160,...
SUMMARY DNA mutations are necessary drivers of cancer, yet only a small subset mutated cells go on to cause the disease. To date, mechanisms that determine which rare transform and initiate tumorigenesis remain unclear. Here, we take advantage unique model intrinsic developmental heterogeneity ( Trim28 +/D9 ) demonstrate stochastic early life epigenetic variation can trigger distinct cancer-susceptibility ‘states’ in adulthood. We show these developmentally primed states characterized by...