A5052242345- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Heparin-Induced Thrombocytopenia and Thrombosis
- Acute Ischemic Stroke Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Ethics in Clinical Research
- COVID-19 Clinical Research Studies
- Cardiovascular Disease and Adiposity
- SARS-CoV-2 and COVID-19 Research
- Neutropenia and Cancer Infections
- Cancer Treatment and Pharmacology
- Chemotherapy-related skin toxicity
- Intramuscular injections and effects
- COVID-19 epidemiological studies
- Inhalation and Respiratory Drug Delivery
- Cystic Fibrosis Research Advances
- Meta-analysis and systematic reviews
- Cerebrovascular and Carotid Artery Diseases
- Biomedical Ethics and Regulation
- Platelet Disorders and Treatments
- Parasitic Diseases Research and Treatment
- Coronary Interventions and Diagnostics
- COVID-19 and Mental Health
Sarawak General Hospital
2018-2025
Ministry of Health
2020-2025
Universiti Sains Malaysia
2024
Hospital Universiti Sains Malaysia
2023
Sibu Hospital
2015
<h3>Importance</h3> Ivermectin, an inexpensive and widely available antiparasitic drug, is prescribed to treat COVID-19. Evidence-based data recommend either for or against the use of ivermectin are needed. <h3>Objective</h3> To determine efficacy in preventing progression severe disease among high-risk patients with <h3>Design, Setting, Participants</h3> The Ivermectin Treatment Efficacy COVID-19 High-Risk Patients (I-TECH) study was open-label randomized clinical trial conducted at 20...
Hand-foot syndrome (HFS) significantly impacts quality of life in cancer patients undergoing capecitabine treatment. This study assessed capecitabine-associated HFS prevalence, its on chemotherapy treatment, and identified risk factors multiracial Malaysian patients.
Despite the expanding landscape of clinical trials, there is a lack study concerning Malaysian patients' participation and perspectives. This addresses these gaps by assessing willingness, knowledge, perceptions, confidence, religious barriers related to trial participations at Sarawak General Hospital. We conducted cross-sectional survey from March September 2022 on 763 cancer non-cancer patients. collected responses calculated scores for willingness participate (40.5/100), knowledge...
<title>Abstract</title> Background: Antiplatelet therapy is a cornerstone of acute ischaemic stroke management, but high on-treatment platelet reactivity (HOTPR) may undermine its efficacy. This study aimed to assess and HOTPR status during the phase following antiplatelet initiation, explore their associations with outcomes in Malaysian cohort. Methods: prospective, observational enrolled 198 patients admitted Sarawak General Hospital. Platelet was measured at baseline on Days 1 3...
Sago starch, rich in type 2 resistant may offer benefits glucose and lipid regulations patients with diabetes. We conducted a double-blind, randomised, controlled trial diabetes patients, randomised 1:1 into intervention (50g/day sago starch) control corn arms. All participants received standardised diet counselling for management given at baseline. The primary outcomes were changes glycaemic endpoints, insulin sensitivity, levels. Secondary included calorie intake, body fat, anthropometric,...
This study aimed to evaluate whether multimedia counselling (MC) using a touchscreen computer is as effective and time-efficient conventional (CC) in promoting correct metered-dose inhaler (MDI) technique, with or without the valved holding chamber (VHC).Participants MDI-only MDI-with-VHC groups were randomly assigned MC group CC group. No blinding was imposed. Inhalation technique assessed checklists before after counselling. Time spent on determined for all participants, while time taken...
Participant recruitment has always been a major challenge in clinical trials. This study aimed to develop and validate the Join Clinical Trial Questionnaire (JoinCT), exploring willingness join trial associated factors patients.This questionnaire development involved four phases: (i) understanding subject matter, (ii) development, (iii) content validity testing, lastly, (iv) field-testing of questionnaire. For phase, cross-sectional self-administered survey JoinCT was conducted among cancer...
Sarawak General Hospital, which is the only public access tertiary referral center in State for all clinical specialties, was designated a hybrid hospital to treat both COVID-19 and non-COVID-19 patients. During initial surge of patients admitted with COVID-19, there also corresponding increase health-care workers (HCWs) detected infection. The latter being isolated, large number staff members that had come into contact quarantined from work, placed further strain on services. mass screening...
Abstract This study assessed the association between COVID-19 vaccines, SARS-CoV-2 infection and risk of thrombocytopenia venous thromboembolism (VTE). self-controlled case series used hospital records 1st February 2021 28th 2022 linked to national immunisation registry surveillance data in Malaysia. Conditional Poisson regression was estimate incidence rate ratios (IRR) events period (day 1–21 post-exposure) relative control with corresponding 95% confidence interval (CI) adjusted for...
<title>Abstract</title> <bold>Introduction</bold> Hand-foot syndrome (HFS) significantly impacts the quality of life in cancer patients undergoing capecitabine treatment. This study assessed capecitabine-associated HFS prevalence, its on chemotherapy treatment, and identified risk factors multiracial Malaysian patients. <bold>Methods</bold> We included adult receiving at Sarawak General Hospital for least two cycles from April 1, 2021 to June 30, 2022. rates, time HFS, proportions...
<title>Abstract</title> Despite the expanding landscape of clinical trials, there is a lack study concerning Malaysian patients’ participation and perspectives. This addresses these gaps by assessing willingness, knowledge, perceptions, confidence, religious barriers related to trial participations in hospital Malaysia. We conducted cross-sectional survey at Sarawak General Hospital from March September 2022, encompassing 763 cancer non-cancer patients. collected responses calculated scores...
Abstract Background Left ventricular diastolic dysfunction (LVDD) has been shown to be more prevalent in patients with diabetes, and once progress overt heart failure, carry worse clinical outcomes, compared those without diabetes. The complexity of previous 2009 ASE/EACVI algorithms makes function (DF) assessment challenging. Hence, prognostic value LVDD estimates setting is not well-established. Objective To evaluate the impact 2016 recommendations predicting cardiovascular outcomes...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Ministry Health Malaysia Background Left ventricular diastolic dysfunction (LVDD) has been shown to be more prevalent in patients with diabetes, and once progress overt heart failure, carry worse clinical outcomes. Substantial number were classified as indeterminate function based on the current ASE/EACVI guidelines. The implication classification predicting MACE among diabetic...
Background: The prognostic value of diastolic dysfunction estimates in clinical settings is not well established. We aimed to evaluate the impact 2016 American Society Echocardiography and European Association Cardiovascular Imaging recommendations on predicting cardiovascular outcomes patients with diabetes hypertension. Methods: In total, 111 hypertension without a known history diseases were enrolled. All had preserved left ventricular ejection fraction echocardiography at screening. was...
Abstract Background Left ventricular diastolic dysfunction (LVDD) has been shown to be more prevalent in patients with diabetes, and once progress overt heart failure, carry worse clinical outcomes. Substantial number of were classified as indeterminate DF based on the current ASE/EACVI guidelines. The implication classification predicting MACE among diabetic is not well established. Purpose To assess prognostic impact guidelines-based classification, determine predictors 2-year individual...