A5044486827- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Coronary Interventions and Diagnostics
- Long-Term Effects of COVID-19
- Health and Lifestyle Studies
- Acute Myocardial Infarction Research
- Vascular Procedures and Complications
- Obesity, Physical Activity, Diet
- Pharmaceutical Economics and Policy
- Parasitic Diseases Research and Treatment
- Healthcare cost, quality, practices
- Retinal Imaging and Analysis
- Medication Adherence and Compliance
- COVID-19 epidemiological studies
- Smoking Behavior and Cessation
- Antibiotic Use and Resistance
- Liver Disease and Transplantation
- SARS-CoV-2 detection and testing
- Birth, Development, and Health
- Ocular Diseases and Behçet’s Syndrome
- Pharmaceutical Practices and Patient Outcomes
- Retinal Diseases and Treatments
Ministry of Health
2014-2024
University of Houston
2022-2024
<h3>Importance</h3> Ivermectin, an inexpensive and widely available antiparasitic drug, is prescribed to treat COVID-19. Evidence-based data recommend either for or against the use of ivermectin are needed. <h3>Objective</h3> To determine efficacy in preventing progression severe disease among high-risk patients with <h3>Design, Setting, Participants</h3> The Ivermectin Treatment Efficacy COVID-19 High-Risk Patients (I-TECH) study was open-label randomized clinical trial conducted at 20...
We aimed to investigate and compare waning vaccine effectiveness (VE) against COVID-19 infection, related ICU admission, COVID-19-related death for BNT162b2 CoronaVac vaccines.We consolidated national data on vaccination outcomes, used cases from September 1st-30th, 2021 VE between the 'early' (fully vaccinated in April-June 2021) 'late' (July-August groups. estimated infection with a negative binomial regression admission among confirmed logistic regression.For BNT162b2, infections declined...
<h3>Importance</h3> Evidence for the timing of booster vaccination after completion BNT162b2 and CoronaVac primary is crucial to guide policy recommendations. <h3>Objective</h3> To compare odds symptomatic SARS-CoV-2 infection COVID-19–related outcomes heterologous homologous boosting at 3-month intervals 6-month intervals, with series (2 doses) as reference group. <h3>Design, Setting, Participants</h3> This population-based retrospective cohort study used national data Malaysia....
To determine if nirmatrelvir-ritonavir 300mg/100mg treatment for 5 days in high-risk outpatients with mild to moderate COVID-19 symptoms was associated a reduction hospitalization, intensive care unit (ICU) admission, and death.This 1:1 propensity score matched cohort study from 647 public health clinics Malaysia included all patients positive tests aged 18 years older, who were eligible within of illness July 14, 2022, November 2022. The exposed group initiated treatment, whereas those not...
Nirmatrelvir/ritonavir was administered orally to manage mild moderate symptoms of COVID-19 in adult patients. The objectives this study were (i) evaluate the cost-effectiveness prescribing nirmatrelvir/ritonavir within 5 days a illness order avert hospitalization 30-day period Malaysia setting; (ii) determine how variations pricing and rates will affect nirmatrelvir/ritonavir. related determined using 1 propensity score-matched real-world data from 14 July 2022 November 2022. To total...
Limitations in the quality and access of cost data from low-income middle-income countries constrain implementation economic evaluations. With increasing prevalence coronary artery disease Malaysia, information is vital for cardiac service expansion. We aim to calculate hospitalisation percutaneous intervention (PCI), using a collection method customised local setting limited availability.This cross-sectional costing study perspective healthcare providers, top-down approach, January June...
Introduction The increasing disease burden of coronary artery (CAD) calls for sustainable cardiac service. Teaching hospitals and general in Malaysia are main providers percutaneous intervention (PCI), a common treatment CAD. Few studies have analyzed the contemporary data on local facilities. Service expansion budget allocation require cost evidence from various providers. We aim to compare patient characteristics, procedural outcomes, profile between teaching hospital (TH) (GH). Methods...
SUMMARY Background Evaluation of vaccine effectiveness over time against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or disease 2019 (COVID-19) is important. Evidence on for the CoronaVac lacking despite its widespread use globally. In Malaysia, a diverse set-up COVID-19 vaccines was rolled out nationwide, and waning protection concern. We aimed to investigate compare infections, related ICU admission deaths BNT162b2 vaccines. Methods this observational study, we...
Background: This retrospective cohort study aimed to examine the interaction effect between puberty stage and weight status on individual clustering of cardiometabolic risk factors (CMRFs) among Mexican American children adolescents. A total 333 adolescents (aged 8-18 years) enrolled in Cameron County Hispanic Cohort (CCHC) from 2014 2020 were included study. Methods: CCHC is a longitudinal, randomly recruited based United States Census tracts/blocks Americans living Texas-Mexico border....
Background This study aimed to compare the obesity rates between border-residing Mexican American children with National Health and Nutritional Surveys (NHANES), examine individual household characteristics associated weight status in these children. Methods was a cross-sectional analysis of 354 aged 8–18 years their parents Cameron County Hispanic Cohort (CCHC) from 2014 2020. Children were categorized as healthy weight, overweight, class 1 obesity, 2 3 obesity. The distribution CCHC...
There was a fluctuation in medication demand and supply during COVID-19 pandemic. This study aimed to assess the trend of drug utilisation Malaysia 2018-2022 evaluate impact on rates. We conducted repeated cross-sectional pharmaceutical sales data from public private sectors 2018 2022. Drug rates for period after onset (2020-2022) compared with earlier (2018-2019). Interrupted time-series regression analyses evaluated level slope changes pre-COVID-19 pandemic quarterly drugs sectors. an...
The effect of nirmatrelvir/ritonavir on preventing post-COVID condition (PCC) in the BA4, BA5, and XBB Omicron predominant periods is not well understood. purpose this study was to assess how treatment affected both PCC health-related quality life. This retrospective cohort enrolled 2,524 adults aged 18 years older who were eligible for between July 14 November 14, 2022. All outcomes observed from patient's first visit primary health clinic, 1 week, month, 3 months, 6 months after testing...
Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness. Both bevacizumab ranibizumab are anti-vascular endothelial growth factors used for treatment AMD. However the use remains controversial as it was not approved intravitreal although there were several head-to-head comparison trial that shows non inferior to ranibizumab. Despite status off-label, being worldwide 30-50 times cheaper than The case illustrates “not-me” drug different countries responds...
Introduction The number of anti-diabetics listed in the Ministry Health Medicine Formulary (MoHMF) and proposal to change prescribing category for usage primary care facilities has increased each year causing difficulty monitoring effectiveness, safety rational use treatment budget management. This study aimed describe reassessment selection strategy Dipeptidyl Peptidase-4 Inhibitors (DPP4-i), a class anti-diabetic medicines MoHMF. Methods A literature review on comparative effectiveness all...