A5018280673- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Sleep and related disorders
- Circadian rhythm and melatonin
- Neuroscience of respiration and sleep
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroendocrine regulation and behavior
- Apelin-related biomedical research
- Anesthesia and Neurotoxicity Research
- Nuclear Receptors and Signaling
- Calcium signaling and nucleotide metabolism
- Vitamin C and Antioxidants Research
- Biochemical effects in animals
- Biochemical Analysis and Sensing Techniques
- Animal Nutrition and Physiology
- Mesenchymal stem cell research
- Medicinal Plants and Neuroprotection
- Migraine and Headache Studies
- Ziziphus Jujuba Studies and Applications
- Birth, Development, and Health
- Pharmacological Effects of Natural Compounds
Shahid Bahonar University of Kerman
2016-2025
Bioscience Research
2016
Shiraz University
2016
Islamic Azad University of Shiraz
2016
Islamic Azad University, Science and Research Branch
2016
Kerman University of Medical Sciences
2016
Chabahar Maritime University
2016
Parkinson's disease (PD) is a common neurodegenerative disorder that characterized by progressive and selective death of dopaminergic neurons. Multifunctional neuropeptide orexin-A involved in many biological events the body. It has been shown protective effects such as PD. However, its cellular mechanisms have not yet fully clarified. Here, we investigated intracellular signaling pathway neuroprotection 6-hydroxydopamine (6-OHDA)-induced SH-SY5H cells damage an vitro model The were...
Parkinson's disease (PD) is a severe neurodegenerative disorder characterized by the loss of brain dopaminergic neurons. Beside pharmacologic and symptomatic treatment PD neuroprotective therapy has recently attracted more attention. Apelin, novel neuropeptide, its receptors have numerous reported roles in regulating functions. In addition, this peptide potent effects some situations. study, apelin-13 were investigated cell model PD. Human neuroblastoma SH-SY5Y damage was induced 150 μM...
Abstract Orexin-A (OXA), a neuropeptide produced in the hypothalamus, is recognized for its role modulating orofacial nociception and regulating feeding behaviors, as well impact on psychophysiological responses. This study investigated of orexin-1 receptors (OX1R) nociceptive behaviors induced by noxious stimulation temporomandibular joint (TMJ) associated changes mood rats with complete Freund’s adjuvant (CFA)-induced disorders (TMDs). Bilateral cannulation lateral ventricles was performed...
Abstract Aim To assess the effects of central administration α‐pinene alone and in combination with either bicuculline or naloxone, as GABA A μ‐opioid receptor antagonists, respectively, on capsaicin‐induced dental pulp stimulation rats. Methodology Forty‐eight adult male Wistar rats aged 2 months (230–270 g) were cannulated via their lateral ventricles for drugs. α‐Pinene was injected at 0.1, 0.2 0.4 μmol L −1 . Then, induced by intradental application capsaicin solution (100 μg),...
The relationship between anxiety and pain has received special attention. Orexins (A B) are hypothalamic neuropeptides that have diverse functions in the regulation of different physiological behavioral responses. This study was designed to evaluate role orexin 1 receptors (OX1R) within trigeminal nucleus caudalis (TNC) following induction orofacial pain. subcutaneous injection capsaicin (CAP) into rat upper lip region produced OX1R agonist (orexin A) antagonist (SB-334867) were...
A general and easy method for the synthesis of 4,6-disubstituted-3-cyano-2(1H)-iminopyridine or 3-amino-6-chloro-1-aryl-1H-benzo[h]chromen-2-yl cyanide derivatives in presence high surface area MgO as a highly effective heterogeneous base catalyst is described. These compounds were synthesized using one-pot multicomponent reactions properly substituted acetophenone, appropriate aldehyde, ammonium acetate malononitrile three component 4-chloro-2-naphthol, aldehydes malononitrile,...
Migraine headaches have been associated with sensory hyperactivity and anomalies in social/emotional responses. The main objective of this study was to evaluate the potential involvement orexin 1 receptors (Orx1R) within basolateral amygdala (BLA) modulation pain psychosocial dysfunction a nitroglycerin (NTG)-induced rat model migraine.Adult male Wistar rats were injected NTG (5 mg/kg, intraperitoneal) every second day over nine days induce migraine. experiments done following six groups (6...
Objectives: Natural products have a potential role on food intake in mammals. It has been reported that phytohormone abscisic acid (ABA) regulatory metabolic processes. Here, the effects of ABA feeding behavior and brain oxidative stress were investigated male Wistar rats. Methods: was injected intracerebroventricularly. Experimental groups included (n = 9): control (received no injection), vehicle normal saline), ABA-treated with different doses (2.5, 5, 10 μg/rat for 7 days). Daily...