A5061406377- Immune Cell Function and Interaction
- Hepatitis C virus research
- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- ICT Impact and Policies
- Immune Response and Inflammation
- CAR-T cell therapy research
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Flexible and Reconfigurable Manufacturing Systems
- Allergic Rhinitis and Sensitization
- Diverse Educational Innovations Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Single-cell and spatial transcriptomics
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Eosinophilic Esophagitis
- Food Allergy and Anaphylaxis Research
- Adolescent and Pediatric Healthcare
- Education, Psychology, and Social Research
- Antenna Design and Analysis
Heidelberg University
2022-2025
University Hospital Heidelberg
2022-2025
University Medical Centre Mannheim
2022
Charles University
2018-2020
Background Immune checkpoint blockade targeting the adaptive immune system has revolutionized treatment of cancer. Despite impressive clinical benefits observed, patient subgroups remain non-responsive underscoring necessity for combinational therapies harnessing additional cells. Natural killer (NK) cells are emerging tools cancer therapy. However, only subpopulations NK that differentially controlled by inhibitory receptors exert reactivity against particular types. How to leverage...
Group 3 helper Innate Lymphoid Cells (ILC3s) are cytokine-producing lymphocytes that respond to stress signals released during disturbed tissue homeostasis and infection. Upon activation, ILC3s secrete IL-22 IL-17, orchestrate immune responses against extracellular pathogens. Their role in cancer remains poorly explored. To determine their anti-cancer effector potential, we co-cultured cytokine-activated human with cells of different origins. were able directly tumor cells, resulting...
Abstract Natural Killer (NK) cells, as key effector cells of the innate immune system, display high heterogeneity in their ability to kill target cells. The underlying mechanisms remain poorly understood. Here, a droplet‐based microfluidic platform is presented identify and select NK with serial killing ability. To this end, primary human are encapsulated several using an efficient negative pressure‐based droplet generator. Capitalizing on large number possible events due quantization into...
Concern exists that the prolonged application of immunomodulators to treat atopic dermatitis may cause systemic immunosuppression.In a 7-month, multicentre, randomised, controlled trial, we investigated equivalence response vaccination against meningococcal serogroup C disease with protein-conjugate vaccine in children (2-11 years) moderate severe dermatitis, by applying either 0.03% tacrolimus ointment (TAC-O; n = 121[corrected]) or hydrocortisone regimen (HC-O; 111).TAC-O was applied twice...
Recent studies have reported that the crosslinking of regulatory receptors (RRs), such as BDCA-2 (CD303) or ILT7 (CD85g), plasmacytoid dendritic cells (pDCs) efficiently suppresses production type I interferons (IFN-I, α/β/ω) and other cytokines in response to Toll-like receptor 7 9 (TLR7/9) ligands. The exact mechanism how this B cell (BCR)-like signaling blocks TLR7/9-mediated IFN-I is unknown. Here we stimulated BCR-like by ligation RRs with mAbs, hepatitis C virus (HCV) particles, BST-2...
Abstract Recombinant interferon-α (IFN-α) treatment functionally cures chronic hepatitis B virus (HBV) infection in some individuals and suppresses replication hepatocytes infected vitro. We studied the antiviral effect of conditioned media (CM) from peripheral blood mononuclear cells (PBMCs) stimulated with agonists Toll-like receptors (TLRs) 2, 7, 8 9. found that CM PBMCs dual-acting TLR7/8 (R848) TLR2/7 (CL413) were more potent drivers inhibition HBe HBs antigen secretion HBV-infected...
The co-infection of hepatitis B (HBV) patients with the D virus (HDV) causes most severe form viral and thus drastically worsens course disease. Therapy options for HBV/HDV are still limited. Here, we investigated potential natural killer (NK) cells that crucial drivers innate immune response against viruses to target HDV-infected hepatocytes. We established in vitro co-culture models using hepatoma cell lines human peripheral blood NK cells. determined activation by flow cytometry,...
Depletion and functional impairment of circulating plasmacytoid dendritic cells (pDCs) are characteristic attributes HIV-1-infection. The mechanism dysfunction pDCs is unclear. Here, we studied the development phenotype in a cohort HIV-1-infected individuals monitored before initiation during 9-month follow up with antiretroviral therapy (ART). Using polychromatic flow cytometry, detected significantly higher pDC-surface expression HIV-1 receptor CD4, regulatory BDCA-2, Fcγ CD32, pDC marker...