A5006692336- Genetics, Aging, and Longevity in Model Organisms
- Spaceflight effects on biology
- Circadian rhythm and melatonin
- Nuclear Structure and Function
- Mitochondrial Function and Pathology
Azienda Unità Sanitaria Locale di Ferrara
2023
Durham University
2021-2023
Finding new interventions that slow ageing and maintain human health is a huge challenge of our time. The nematode Caenorhabditis elegans offers rapid in vivo method to determine whether compound extends its 2 3-week lifespan. Measuring lifespan the standard monitor ageing, but will not necessarily health. Here, we describe automated monitoring C. movement from early mid-adulthood as faster healthspan-based measure ageing. Using WormGazer™ technology, multiple Petri dishes each containing...
The increase in our molecular understanding of the biology aging, coupled with a recent surge investment, has led to formation several companies developing pharmaceuticals slow aging. Research using tiny nematode worm Caenorhabditis elegans was first show that mutations single genes can extend lifespan, and subsequent research shown this model organism is uniquely suited testing interventions Yet, few notable exceptions, C. not standard toolkit longevity companies. Here we discuss paths...
Abstract Finding new interventions that slow ageing and maintain human health is a huge challenge of our time. The nematode Caenorhabditis elegans , offers rapid in vivo method to determine whether compound extends its 2-3 week lifespan. However, the standard C. lifespan assay hard scale for large screens. Lifespan analysis produces only one data point per animal with no information about health. Here we describe automated monitoring movement from early mid-adulthood as healthspan-based...