A5024171545- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Protein Kinase Regulation and GTPase Signaling
- Cell death mechanisms and regulation
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Melanoma and MAPK Pathways
- Colorectal Cancer Treatments and Studies
- PI3K/AKT/mTOR signaling in cancer
- Toxin Mechanisms and Immunotoxins
University of Stuttgart
2016-2018
University of Freiburg
2013-2015
Abstract The activation kinetics of MAPK Erk are critical for T cell development and activation. In particular, sustained signaling is required effector functions, such as IL-2 production. Although Raf-1 triggers transient activation, B-Raf implicated in after TCR stimulation. this study, we show that dephosphorylated on its inhibitory serine 365 upon triggering. However, it unknown how coupled to the TCR. Using mass spectrometry, identified protein kinase D–interacting substrate 220 kDa...
Human epidermal growth factor receptor 3 (HER3, also known as ErbB3) has emerged relevant target for antibody-mediated tumor therapy. Here, we describe a novel human antibody, IgG 3–43, recognizing unique epitope formed by domain III and parts of IV the extracellular region HER3, conserved between HER3 mouse ErbB3. An affinity 11 nM was determined monovalent interaction. In format, antibody bound recombinant bivalent with subnanomolar (KD = 220 pM) HER3-expressing cells EC50 values in low...
// Yvonne Möller 1 , Markus Morkel 2 Jens Schmid 3 Sven Beyes 1, 8 Janina Hendrick Michaela Strotbek Pamela Riemer 2, 4 Simone Lisa C. Schmitt Roland Kontermann 5 Thomas Mürdter Matthias Schwab 3, 6, 7 Christine Sers Monilola A. Olayioye Institute of Cell Biology and Immunology, University Stuttgart, Germany Laboratory Molecular Tumor Pathology Systems Biology, Pathology, Charité Universitätsmedizin Berlin, Dr. Margarete Fischer-Bosch Clinical Pharmacology Tübingen, DKTK, German Cancer...
// Meike Hutt 1 , Sina Fellermeier-Kopf Oliver Seifert Lisa C. Schmitt Klaus Pfizenmaier 1, 2 and Roland E. Kontermann Institute of Cell Biology Immunology, University Stuttgart, Stuttgart 70569, Germany Research Center Systems Biology, Correspondence to: Kontermann, email: roland.kontermann@izi.uni-stuttgart.de Keywords: TRAIL; targeting; affinity; receptor expression; apoptosis Received: December 14, 2017 Accepted: January 25,...