A5074689146- Phytochemistry Medicinal Plant Applications
- Piperaceae Chemical and Biological Studies
- Plant tissue culture and regeneration
- Traditional and Medicinal Uses of Annonaceae
- Microbial Metabolites in Food Biotechnology
- Pharmacological Effects of Natural Compounds
- Monoclonal and Polyclonal Antibodies Research
- Phytochemical and Pharmacological Studies
- Advanced Drug Delivery Systems
- Food Science and Nutritional Studies
- Renal function and acid-base balance
- Click Chemistry and Applications
- Natural product bioactivities and synthesis
- Bioactive natural compounds
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Alkaloids: synthesis and pharmacology
- Hedgehog Signaling Pathway Studies
- Phytochemicals and Antioxidant Activities
- Pneumonia and Respiratory Infections
- Clinical Nutrition and Gastroenterology
- Gastrointestinal motility and disorders
- Phytochemical compounds biological activities
- Cocoa and Sweet Potato Agronomy
- Diet and metabolism studies
- Inhalation and Respiratory Drug Delivery
Universidade Estadual de Campinas (UNICAMP)
2010-2016
University of L'Aquila
1996-2001
Systemic administration of bio-therapeutics can result in only a fraction drug reaching targeted tissues, with the majority being distributed to tissues irrelevant drug's site action. Targeted delivery specific organs may allow for greater accumulation, better efficacy, and improved safety. We investigated how targeting plasmalemma vesicle-associated protein (PV1), found endothelial caveolae lungs kidneys, promote accumulation these organs. Using ex vivo fluorescence imaging, we show that...
Phytochemical investigation of the bark Guatteria friesiana afforded 12 new aporphines (1–12), along with nine known alkaloids (13–21). The structures were determined on basis spectroscopic data interpretation. cytotoxic activity isolated compounds against a small panel tumor cell lines was assessed using Alamar blue assay.
IgG antibodies are abundantly present in the vasculature but to a much lesser extent mucosal tissues. This contrasts with of IgA and IgM isotype that at high concentration secretions due active delivery by polymeric Ig receptor (pIgR). is preferred for therapeutic mAb development its long serum half-life robust Fc-mediated effector function, it utilized treat diverse array diseases antigen targets located vasculature, serosa, mucosa. As targeting luminal side tissue lack an transport...
A investigação fitoquímica das folhas de Guatteria friesiana (Annonaceae) levou à obtenção três novos alcaloides isoquinolínicos, 13-hidroxi-discretinina, 6,6a-desidroguateriopsiscina e 9-desidroxi-1-metoxi-diidroguattouregidina,
Arucanolide is a germacranolide, isolated from the dichloromethane leaves' crude extract. Germacranolides are frequently described as responsible for antiproliferative activities with apoptosis induction. Therefore, study of anticancer activity C. pinnatifida extracts and substances became important. This compound was identified involved by bio-guided assays evaluated in nine different tumor one normal cell lines. Samples were tested concentration range 0.25 to 250µg/ml measured...