A5017222436- Genetics, Aging, and Longevity in Model Organisms
- Diabetes Treatment and Management
- Circadian rhythm and melatonin
- Pancreatic function and diabetes
- Insect and Arachnid Ecology and Behavior
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Polyomavirus and related diseases
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Physiological and biochemical adaptations
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2022-2024
Warsaw University of Technology
2021-2022
Abstract Extracellular vesicles (EVs) are integral to numerous biological processes, yet it is unclear how environmental factors or interactions among individuals within a population affect EV-regulated systems. In Caenorhabditis elegans , the evolutionarily conserved large EVs, known as exophers, part of maternal somatic tissue resource management system. Consequently, offspring exhibiting active exopher biogenesis (exophergenesis) develop faster. Our research focuses on unraveling complex...
Graft-versus-host disease (GVHD) continues to emerge as the topmost causative factor of morbidity and mortality rate post hematopoietic stem cell transplantation. The graft cells attack recipient host tissues resulting in acute or chronic GVHD that affect organs, including lung, liver, skin, gastrointestinal tract. Certain factors are considered play a crucial role progression disease, such antibodies produced by B cells, reduction regulatory T immune tolerance disruption self-antigen. This...
Abstract Extracellular vesicles (EVs) are involved in multiple biological processes; however, there is limited knowledge of the influence environmental factors or other individuals a population on EV-regulated systems. The largest evolutionarily conserved EVs, exophers, component C. elegans maternal somatic tissue resource management system induced by embryos developing utero , and thus progeny with active exopher biogenesis (exophergenesis) appear to be privileged. Using this model, we...
Abstract BackgroundPreviously, numerous case-control studies have highlighted variants responsible for Maturity onset diabetes of young (MODY). However, these been conducted among diverse populations and hence yielded contradictory results. We, therefore, performed a meta-analysis to precisely find the association SNPs with disease HNF1A gene.ObjectiveMeta-analysis clinically defined deciphering mutations in gene development MODY3 was various determine associations using statistical...