A5054634101- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Neuroscience and Music Perception
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
- Single-cell and spatial transcriptomics
- Zebrafish Biomedical Research Applications
- Action Observation and Synchronization
- Neuroscience and Neuropharmacology Research
Allen Institute
2023-2025
Allen Institute for Neural Dynamics
2023-2025
University of Oregon
2020-2024
High-resolution extracellular electrophysiology is the gold standard for recording spikes from distributed neural populations, and especially powerful when combined with optogenetics manipulation of specific cell types high temporal resolution. We integrated these approaches into prototype Neuropixels Opto probes, which combine electronic photonic circuits. These devices pack 960 electrical sites two sets 14 light emitters onto a 1 cm shank, allowing spatially addressable optogenetic...
Sensory systems integrate multiple stimulus features to generate coherent percepts. Spectral surround suppression, the phenomenon by which sound-evoked responses of auditory neurons are suppressed stimuli outside their receptive field, is an example this integration taking place in system. While form global commonly observed cortical neurons, and potentially used nervous system separate signals from noise, mechanisms that underlie suppression activity not well understood. We evaluated...
Abstract Cells of different types perform diverse computations and coordinate their activity during sensation, perception, action. While electrophysiological approaches can measure the many neurons simultaneously, assigning cell type labels to these is an open problem. Here, we develop PhysMAP, a framework that weighs multiple modalities simultaneously in unsupervised manner obtain interpretable representation separates by type. PhysMAP superior any single modality identifying neuronal such...
Behavioral neuroscience faces two conflicting demands: long-duration recordings from large neural populations and unimpeded animal behavior. To meet this challenge, we developed ONIX, an open-source data acquisition system with high throughput (2GB/sec) low closed-loop latencies (<1ms) that uses a novel 0.3 mm thin tether to minimize behavioral impact. Head position rotation are tracked in 3D used drive active commutation without torque measurements. ONIX can acquire combinations of passive...
Behavioral neuroscience faces two conflicting demands: long-duration recordings from large neural populations and unimpeded animal behavior. To meet this challenge we developed ONIX, an open-source data acquisition system with high throughput (2 GB s
The ability to separate background noise from relevant acoustic signals is essential for appropriate sound-driven behavior in natural environments. Examples of this separation are apparent the auditory system, where neural responses behaviorally stimuli become increasingly invariant along ascending pathway. However, mechanisms that underlie reduction not well understood. To address gap knowledge, we first evaluated effects cortical inactivation on mice both sexes trained perform a simple...
Abstract To understand the neural basis of behavior, it is essential to measure spiking dynamics across many interacting brain regions. While new technologies, such as Neuropixels probes, facilitate multi-regional recordings, significant surgical and procedural hurdles remain for these experiments achieve their full potential. Here, we describe a novel 3D-printed cranial-replacement implant (SHIELD) enabling electrophysiological recordings from distributed areas mouse brain. This...
Given its inputs from auditory structures and neuromodulatory systems, the posterior tail of striatum is ideally positioned to influence behavioral responses acoustic stimuli according context previous rewards. Results studies indicate that neurons in this striatal region display selective sounds. However, it not clear whether different cell classes code for distinct features sounds or how output pathways may use information guide behavior. Here we compared sound-evoked form direct pathway...
Abstract Given its inputs from auditory structures and neuromodulatory systems, the posterior tail of striatum is ideally positioned to influence behavioral responses acoustic stimuli according context previous rewards. Results studies indicate that neurons in this striatal region display selective sounds. However, it not clear whether different cell classes code for distinct features sounds, nor how output pathways may use information guide behavior. Here we compared sound-evoked form...
Abstract The ability to separate background noise from relevant acoustic signals is essential for appropriate sound-driven behavior in natural environments. Examples of this separation are apparent the auditory system, where neural responses behaviorally stimuli become increasingly noise-invariant along ascending pathway. However, mechanisms that underlie reduction not well understood. To address gap knowledge, we first evaluated effects cortical inactivation on mice both sexes trained...