A5062101056- Algal biology and biofuel production
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
- Dietary Effects on Health
- Advanced Nanomaterials in Catalysis
- Cellular Mechanics and Interactions
- Protein Hydrolysis and Bioactive Peptides
- Echinoderm biology and ecology
- Marine Biology and Environmental Chemistry
- 3D Printing in Biomedical Research
- Tannin, Tannase and Anticancer Activities
- Cancer, Hypoxia, and Metabolism
- Nutrition, Genetics, and Disease
- Microbial Community Ecology and Physiology
- Marine Sponges and Natural Products
- Antioxidant Activity and Oxidative Stress
- Angiogenesis and VEGF in Cancer
- Microplastics and Plastic Pollution
- Kruppel-like factors research
- Phytochemical compounds biological activities
- Modular Robots and Swarm Intelligence
- Biocrusts and Microbial Ecology
Stazione Zoologica Anton Dohrn
2021-2025
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2024
University of Naples Federico II
2020
Photochemoprevention can be a valuable approach to counteract the damaging effects of environmental stressors (e.g., UV radiations) on skin. Pigments are bioactive molecules, greatly attractive for biotechnological purposes, and with promising applications human health. In this context, marine microalgae alternative eco-sustainable source pigments that still need taken advantage of. study, comparative in vitro photochemopreventive twenty carcinogenic melanoma model cell B16F0 from UV-induced...
Xanthophylls, a group of carotenoids, have attracted attention as human health benefit compounds thanks to their functionality and bioavailability. The great antioxidant anti-inflammatory abilities diatoxanthin (Dt), photoprotective xanthophyll synthetized by diatoms, were recently documented. This study investigates the capacity Dt intercept prostate cancer progression in vitro on different cell lines, exploring its role against proliferation angiogenesis. Our results highlighted...
The exploration of natural preventive molecules for nutraceutical and pharmaceutical use has recently increased. In this scenario, marine microorganisms represent an underestimated source bioactive products endowed with beneficial effects on health that include anti-oxidant, anti-inflammatory, differentiating, anti-tumor, anti-angiogenic activities. Here, we tested the potential chemopreventive activities extract from coastal diatom Skeletonema marinoi Sarno Zingone (Sm) prostate cancer...
Phytohormones represent a group of secondary metabolites with different chemical structures, in which belong auxins, cytokinins, gibberellins, or brassinosteroids. In higher plants, they cover active roles growth defense function, while their potential benefits for human health protection were noted some phytohormones and little explored many others. this study, we developed target fishing strategy on fifty-three selected naturally occurring covering families towards proteins involved key...
Contact between SARS-CoV-2 and human lung cells involves the viral spike protein angiotensin-converting enzyme 2 (ACE2) receptor on epithelial cells, latter being strongly involved in regulation of inflammation as well blood pressure homeostasis. infection is characterized by a strong inflammatory response defined "cytokine storm". Among recent therapeutic approaches against targeting dramatic reaction, some natural products are promising. Diatoms microalgae able to produce bioactive...
Microalgae represent a suitable and eco-sustainable resource for human needs thanks to their fast growth ability, together with the great diversity in species intracellular secondary bioactive metabolites. These high-added-value compounds are of interest health or animal feed. The content these valuable compound families is tightly associated microalgal biological state responds environmental cues, e.g., light. Our study develops Biotechnological response curve strategy exploring metabolites...
Microalgal biotechnology is gaining importance. However, key issues in the pipeline from species selection towards large biomass production still require improvements to maximize yield and lower microalgal costs. This study explores a co-cultivation strategy improve bioactive compounds richness of harvested biomass. Based on their biotechnological potential, two diatoms (Skeletonema marinoi, Cyclotella cryptica) one eustigmatophyte (Nannochloropsis oceanica) were grown alone or combination....
Abstract Introduction: Natural bioactive pigments are of great interest for human health. Marine organisms underexplored as source useful metabolites. Diatoms produce diatoxantin (diatox), a xanthophyll with several properties (chemo-preventive, anti-inflammatory, antioxidant, photoprotective, immunomodulatory), that may have beneficial effects. Doxorubicin (doxo) is still one the most effective chemotherapeutic drugs used in breast cancer (BC) treatment, but has side effects, particularly...
Background Breast Cancer (BC) prevention strategies range from lifestyle changes such as increasing physical activity and reducing body weight to preventive drugs like tamoxifen, known reduce BC incidence in high-risk women. Sex Hormone Binding Globulin (SHBG) is related risk due its ability bind circulating estradiol at high affinity regulate action. A study protocol presented based on the assessment of effect different interventions tamoxifen 10 mg every other day (LDT), intermittent...
The extracellular microenvironment proved to exert a potent regulatory effect over different aspects of Embryonic Stem Cells (ESCs) behavior. In particular, the employment engineered culture surfaces aimed at modulating ESC self-organization resulted effective in directing ESCs toward specific fate decision. fluctuate among levels functional potency and this context Zscan4 gene marks so-called "metastate", cellular state which retain both self-renewal pluripotency capabilities. Here we...
The treatment of inflammatory and immune-related diseases due to dysfunctioning the immune system necessitates modulation response through immunomodulatory compounds. Marine environments are considered as a new frontier for health benefit product implementations. biodiversity is still low explored resource, despite it expected represent an important platform chemical bioactive Within phylum Mollusca, gastropods known synthetize mucus, latter presenting relevant properties, e.g., related...
Abstract Background: Research and production of natural anti-oxidants is growing developed both in experimental laboratories nutraceuticals pharmaceutical industries. Marine microorganisms represent underestimated sources bioactive compounds endowed with anti-oxidant, anti-inflammatory, cardiovascular protective anti-angiogenic properties, all beneficial effects on human health. Methods: Chemopreventive activities extracts from the marine coastal diatom Skeletonema marinoi (Sm) carotenoid...