A5073975527- Ion channel regulation and function
- RNA Research and Splicing
- bioluminescence and chemiluminescence research
- Enzyme Structure and Function
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Chemical Reactions and Isotopes
- Ion Transport and Channel Regulation
- Caveolin-1 and cellular processes
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- Angiogenesis and VEGF in Cancer
- Algal biology and biofuel production
- thermodynamics and calorimetric analyses
- Amino Acid Enzymes and Metabolism
- Animal Virus Infections Studies
- Mass Spectrometry Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Immune responses and vaccinations
- Cell Adhesion Molecules Research
- Bacillus and Francisella bacterial research
- interferon and immune responses
- Immune cells in cancer
- Inflammasome and immune disorders
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
MultiMedica
2021-2024
University of Milan
2017-2021
Angiotensin-converting enzyme 2 (ACE2) is a receptor for the spike protein of SARS-COV-2 that allows viral binding and entry expressed on surface several pulmonary non-pulmonary cell types, with induction “cytokine storm” upon binding. Other types present can be infected, including cardiac, renal, intestinal, endothelial cells. High ACE2 levels protect from inflammation. Despite relevance in COVID-19 pathogenesis, experimental studies to comprehensively address question regulations are still...
Natural Killer (NK) cells have been found to be anergic, exhausted and pro-angiogenic in cancers. NK cell from healthy donors, exposed TGFβ, acquire the CD56brightCD9+CD49a+ decidual-like-phenotype, together with decreased levels of NKG2D activation marker, increased TIM-3 exhaustion similar cancer-associated cells. Tissue inhibitors metalloproteases (TIMPs) exert dual roles cancer. The role TIMPs modulating immune is a very novel concept, present first report studying their ability contrast...
The exploration of natural preventive molecules for nutraceutical and pharmaceutical use has recently increased. In this scenario, marine microorganisms represent an underestimated source bioactive products endowed with beneficial effects on health that include anti-oxidant, anti-inflammatory, differentiating, anti-tumor, anti-angiogenic activities. Here, we tested the potential chemopreventive activities extract from coastal diatom Skeletonema marinoi Sarno Zingone (Sm) prostate cancer...
Pathologies that lead to neurodegeneration in the central nervous system (CNS) represent a major contemporary medical challenge. Neurodegenerative processes, like those occur Alzheimer’s disease (AD) are progressive, and at moment, they unstoppable. Not only is an adequate therapy missing but diagnosis also extremely complicated. The most reliable method measurement of beta amyloid tau peptides concentration cerebrospinal fluid (CSF). However, collecting liquid samples from CNS invasive...
Glioblastoma (GB) is the most lethal, aggressive, and diffuse brain tumor. The main challenge for successful treatment targeting cancer stem cell (CSC) subpopulation responsible tumor origin, progression, recurrence. Chloride Intracellular Channel 1 (CLIC1), highly expressed in CSCs, constitutively present plasma membrane where it associated with chloride ion permeability. In vitro, CLIC1 inhibition leads to a significant arrest of GB CSCs G1 phase cycle. Furthermore, knockdown impairs...
Liver and heart disease are major causes of death worldwide. It is known that metabolic alteration causing type 2 diabetes (T2D) Nonalcoholic fatty liver (NAFLD) coupled with a derangement in lipid homeostasis, may exacerbate hepatic cardiovascular diseases. Some pharmacological treatments can mitigate organ dysfunctions but the important side effects limit their efficacy leading often to deterioration tissues. needs develop new personalized treatment approaches recent progresses engineered...
Objective Several therapies with immune-modulatory functions have been proposed to reduce the overwhelmed inflammation associated COVID-19. Here we investigated impact of IL-10 in COVID-19, through ex-vivo assessment effects exogenous on SARS-CoV-2-specific-response using a whole-blood platform. Methods Two cohorts were evaluated: “study population A”, plasma levels 27 immune factors measured by multiplex (Luminex) assay 39 hospitalized “COVID-19 patients” and 29 “NO COVID-19 controls” all...
Periodontal disease (PD) during pregnancy may trigger systemic inflammation, increasing the risk of developing cardiometabolic (CMD). As a consequence, PD result in activation cellular and molecular pathways, affecting course outcome. Although microRNAs (miRNAs) are considered ideal biomarkers for many diseases, few studies have investigated salivary miRNAs their role or neonatal outcomes. In this study, we sought to investigate associations between pregnant women with oral diseases effects...
Abstract Glioblastoma (GBM) is the most aggressive and lethal brain tumor and, despite surgery adjuvant radiotherapy and/or chemotherapy, prognosis remains invariantly poor. As for of solid hematological malignancies, it was demonstrated that bulk cells in GBM generated by a rare fraction self-renewing, multipotent cancer stem (CSCs) persistence CSCs within mass considered main determinant development, progression, recurrence radio- or chemoresistance. Thus, one goals current research to...
<p>Current density/voltage relationships of CLIC1 current in CSCs</p>
<p>Current density/voltage relationships of CLIC1 current in CSCs</p>
<p>Quantitative real-time PCR for CLIC5 protein.</p>
<p>IAA-94 blockade induces G1 cell cycle arrest in GBM cancer stem cells.</p>
<p>CLIC1 silencing western blot.</p>
<p>Effect of IAA on apoptosis in GB CSCs.</p>
Abstract Background: Research and production of natural anti-oxidants is growing developed both in experimental laboratories nutraceuticals pharmaceutical industries. Marine microorganisms represent underestimated sources bioactive compounds endowed with anti-oxidant, anti-inflammatory, cardiovascular protective anti-angiogenic properties, all beneficial effects on human health. Methods: Chemopreventive activities extracts from the marine coastal diatom Skeletonema marinoi (Sm) carotenoid...
<div>Abstract<p>Glioblastoma (GB) is the most lethal, aggressive, and diffuse brain tumor. The main challenge for successful treatment targeting cancer stem cell (CSC) subpopulation responsible tumor origin, progression, recurrence. Chloride Intracellular Channel 1 (CLIC1), highly expressed in CSCs, constitutively present plasma membrane where it associated with chloride ion permeability. <i>In vitro</i>, CLIC1 inhibition leads to a significant arrest of GB CSCs...
<div>Abstract<p>Glioblastoma (GB) is the most lethal, aggressive, and diffuse brain tumor. The main challenge for successful treatment targeting cancer stem cell (CSC) subpopulation responsible tumor origin, progression, recurrence. Chloride Intracellular Channel 1 (CLIC1), highly expressed in CSCs, constitutively present plasma membrane where it associated with chloride ion permeability. <i>In vitro</i>, CLIC1 inhibition leads to a significant arrest of GB CSCs...
<p>IAA-94 blockade induces G1 cell cycle arrest in GBM cancer stem cells.</p>
<p>Effect of IAA on apoptosis in GB CSCs.</p>