A5012911897- Cancer-related Molecular Pathways
- Effects of Radiation Exposure
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
- Radiation Therapy and Dosimetry
- Cancer Cells and Metastasis
- Hearing Impairment and Communication
- Cancer Research and Treatments
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Microtubule and mitosis dynamics
- HER2/EGFR in Cancer Research
- Hand Gesture Recognition Systems
- Immunotherapy and Immune Responses
- Radiopharmaceutical Chemistry and Applications
- Nuclear Physics and Applications
- DNA Repair Mechanisms
- Radiation Effects and Dosimetry
- Immune Cell Function and Interaction
- Language Development and Disorders
- Language, Discourse, Communication Strategies
- Estrogen and related hormone effects
- RNA modifications and cancer
The University of Texas MD Anderson Cancer Center
2011-2023
University College London
1996-2021
Radiation Oncology Associates
1997-2015
University of California, Los Angeles
1981-2015
City, University of London
2010-2014
Taiho Oncology (United States)
2011
Taiho Pharmaceutical (Japan)
2011
Gwynedd Mercy University
2011
Merck & Co., Inc., Rahway, NJ, USA (United States)
2011
Cornell University
2006
Radiotherapy is commonly used to treat a variety of solid tumors. However, improvements in the therapeutic ratio for several disease sites are sorely needed, leading us assess molecularly targeted therapeutics as radiosensitizers. The aim this study was wee1 kinase inhibitor, MK-1775, its ability radiosensitize human tumor cells.Human cells derived from lung, breast, and prostate cancers were tested radiosensitization by MK-1775 using clonogenic survival assays. Both p53 wild-type...
Using an assay for jejunal crypt stem cell survival, the biological effectiveness of two cyclotron-produced neutron beams relative to one another and 60Co γ-radiation has been determined at doses order used per fraction in clinical trials neutrons. Dose survival curves were using up 5 neutrons 20 dose-fractions γ rays. There is little sparing mucosa as a result repair sublethal injury during intervals between dose fractions, whereas such considerable when γ-ray are fractionated. The response...
Abstract Synthetic oligodeoxynucleotides containing unmethylated CpG motifs detected by Toll-like receptor 9 of dendritic cells and B have potent immunomodulatory effects. induce cytokines, activate natural killer cells, elicit T-cell responses leading to antitumor effects, including improved efficacy chemotherapeutic agents and, as we reported recently, synergy between oligodeoxynucleotide 1826 single-dose radiotherapy an immunogenic mouse fibrosarcoma. The present study extends this...
Abstract CpG oligodeoxynucleotides (ODNs) are synthetic DNA sequences containing unmethylated cytosine-guanine motifs with potent immunomodulatory effects. Via Toll-like receptor 9 agonism of dendritic cells and B cells, ODNs induce cytokines, activate natural killer elicit vigorous T-cell responses that lead to significant antitumor effects, including improved efficacy chemotherapeutic agents. On the basis these properties ODNs, we tested whether they also could enhance tumor response...
Research into the effect of phonetic complexity on phonological acquisition has a long history in spoken languages. This paper considers phonetics development signed language. We report an experiment which nonword-repetition methodology was adapted so as to examine systematic way how two parameters languages — handshape and movement affects perception articulation signs. Ninety-one Deaf children aged 3–11 acquiring British Sign Language (BSL) 46 hearing nonsigners 6–11 repeated set 40...
This paper presents the first ever group study of specific language impairment (SLI) in users sign language. A 50 children were referred to by teachers and speech therapists. Individuals who fitted pre‐determined criteria for SLI then systematically assessed. Here, we describe detail performance 13 signing deaf aged 5–14 years on normed tests British Sign Language (BSL) sentence comprehension, repetition nonsense signs, expressive grammar narrative skills, alongside non‐verbal intelligence...
ABSTRACT We adapted the semantic fluency task into British Sign Language (BSL). In Study 1, we present data from twenty-two deaf signers aged four to fifteen. show that same ‘cognitive signatures’ characterize this in spoken languages are also children, for example, clustering of responses. 2, thirteen children with Specific Impairment (SLI) BSL, comparison a subset 1 matched age and BSL exposure. The two groups' results were comparable most respects. However, group SLI made occasional...
Recent studies suggest that deaf children perform more poorly on working memory tasks compared to hearing children, but do not say whether this poorer performance arises directly from deafness itself or children’s reduced language exposure. The issue remains unresolved because findings come (1) are verbal as opposed non-verbal, and (2) involve who use spoken communication therefore may have experienced impoverished input delayed acquisition. This is in contrast been exposed a sign since...
An assay for the survival of renal tubule cells was developed using mice. It is analogous to other in-situ clonogenic cell assays. One kidney irradiated a 137Cs irradiator and removed 60–68 weeks later histological examination. In unirradiated animals there were about 370 tubules in contact with capsule coronal cross section at middle kidney. After irradiation, extensive tubular damage dominant lesion. The number epithelialised showed dose-dependent logarithmic decline. dose–survival...
Background. Gemcitabine and radiotherapy are a potent combination. A clinical assessment of the therapeutic ratio for locally advanced pancreatic cancer patients has not yet been reported. Aim Study. To assess toxicity, survival, pattern failure treated with concurrent gemcitabine-based chemoradiation. Patients Methods. Between dates December 1996 August 2000 51 unresectable adenocarcinoma pancreas were gemcitabine at MDACC. received 250–500 mg/m2 weekly ×7 over 30 min 30–33 Gy in 10–11...
Abstract Purpose: 130-nm albumin–bound paclitaxel (nab-paclitaxel) is a novel solvent-free albumin-bound paclitaxel, designed to avoid solvent-related toxicity. Nab-paclitaxel has been successfully introduced into the clinic but its radiation-enhancing potential not yet evaluated. We conducted preclinical evaluation of radiation-modulating effects nab-paclitaxel in tumor and normal tissues. Experimental Design: Mice bearing syngeneic ovarian or mammary carcinomas were treated with...
Children with specific language impairment (SLI) perform poorly on sentence repetition tasks across different spoken languages, but until now, this methodology has not been investigated in children who have SLI a signed language. Users of natural sign encode meanings through their choice signs and by altering the sequence inflections these signs. Grammatical information is expressed movement configurational changes hands face. The visual modality thus influences how grammatical morphology...
The impact of music interventions on the cognitive skills young children has become focus a growing number research studies in recent years. This study investigated effect weekly musicianship training executive function abilities 3-to-4-year-old at London, United Kingdom preschool, using two-phase experimental design. In Phase 1, 14 (Group A) took part eight classes, provided by specialist teacher, while 25 (Groups B and C combined) engaged nursery free play. Results this showed Group A to...