Abstract The incidence and mortality rates in kidney cancer (KC) are increasing. However, the trends for have varied among regions over past decade, which may be due to disparities medical settings, such as availability of frequent imaging examinations effective systemic therapies. these two options has been proven positively correlated with a favorable prognosis KC more common countries better health care systems greater expenditures. delicate association between clinical outcomes warrant...

The variation in the mortality-to-incidence ratio (MIR) between countries and genders reflects complex etiology intervention of bladder cancer. In this study, we investigated MIR health care disparities among countries. Cancer incidence mortality were obtained from GLOBOCAN 2012 database. ranking total expenditure on World Health Organization. Linear regression was used to estimate significance variables. We estimated role MIRs 33 Bladder cancer rates higher more developed regions, Europe,...

Oral cancer is a common with poor prognosis. We evaluated the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its prognostic significance in oral cancer. was measured by immunohistochemical staining samples from 287 patients The association between clinicopathological features analyzed. value for overall survival determined Kaplan-Meier analysis Cox proportional hazard models. A high level correlated long survival. role significant young (p < 0.05),...

Intravesical instillation (IVI) of Bacillus Calmette-Guerin (BCG) can prevent bladder cancer recurrence, but this agent has been out stock in recent years. IVI other agents, like chidamide, a histone deacetylase (HDAC) inhibitor, may have the potential to exert therapeutic effect against by modifying gene expression profiles associated with modifications that occur during tumorigenesis. Here, we investigated vitro chidamide and/or mitomycin C cell lines and screened related molecular...

Intra-abdominal retained surgical sponge is an uncommon error. Herein, we report a 92-year-old woman who was brought to the emergency room for acute urinary retention. She had history of vaginal hysterectomy uterine prolapse 18 years previously, performed at our hospital. Retained in pelvic cavity suspected by abdominal computed tomography. The gauze removed laparotomy excision and final diagnosis gossypiboma.

The advancements in cancer therapy have improved the clinical outcomes of patients recent decades. However, advanced is expensive and requires good health care systems. For kidney cancer, no studies yet established an association between outcome disparities. We used mortality-to-incidence ratio (MIR) for as a marker to compare World Health Organization (WHO) country rankings total expenditures on health/gross domestic product (e/GDP) using linear regression analyses. included 57 countries...

STEAP1 (six transmembrane epithelial antigen of the prostate 1) is a protein that functions as potential channel or transporter protein. It overexpressed in certain cancers and viewed promising therapeutic target. However, prognostic role still controversial, no for has yet been indicated colorectal cancer. The aim this study was to investigate possible association expression with cancer prognosis. analyzed by immunohistochemical staining tissue array 165 specimens from primary patients....

To determine if there are clinical and urodynamic (UD) differences between female overactive bladder (OAB) patients with oversensitivity (BO) detrusor overactivity (DO) via a much lower filling rate.In total, 205 OAB symptoms were recruited for this study. During cystometry, the was filled at more "physiological" rate of 20 ml/min. All underwent complete urogynecological evaluation including detailed history, physical examination, urinalysis, pad test quantification urine leakage, 3-day...

Objective The colorectal cancer mortality-to-incidence ratio (MIR) can reflect healthcare disparities. However, a similar association has not yet been established between the MIR of pancreatic and Methods In this study, incidence mortality rates were obtained from GLOBOCAN 2012 database. WHO rankings total expenditures on health/gross domestic product (e/GDP) public Linear regression was performed to determine correlations variables. Results 57 countries met inclusion criteria according data...

Prostate cancer mortality-to-incidence ratios (MIRs) are associated with the level of available healthcare. However, no data currently to show an association between differences in prostate MIRs and healthcare disparity. In present study, changes MIR over time (δMIR) were calculated as difference 2018 2012. The significance expenditures on human development index (HDI) analyzed using Spearman's rank correlation coefficient. A total 47 countries studied. Countries excluded based inadequate...

Azacitidine, an inhibitor of DNA methylation, shows therapeutic effects against several malignancies by inducing apoptosis and inhibiting tumor cell proliferation. However, the anti-tumor azacitidine on urinary bladder urothelial carcinoma (UBUC), especially following intravesical instillation (IVI), are not established. Here, UBUC lines were used to analyze in vitro azacitidine. Potential signaling pathways investigated antibody arrays Western blotting. The N-butyl-N-(4-hydroxybutyl)...

Objective: The aim of this study was to compare the results a transrectal ultrasound-guided botulinum toxin injection with those cystoscopy-guided method external urethral sphincter in treating detrusor dyssynergia. Design: A total 18 suprasacral spinal cord-injured patients dyssynergia were included present study. single dose 100 IU applied into via transperineal route. We retrospectively compared outcome measurements 20 previously treated same through procedure. Results: There significant...

The mortality-to-incidence ratio (MIR) is associated with the clinical outcome of cancer treatment. For several cancers, countries relatively good health care systems have favorable MIRs. However, association between lung MIR and expenditures or rankings has not been evaluated. We used linear regression to analyze correlation MIRs total on health/gross domestic product (e/GDP) World Health Organization (WHO) rankings. included 57 countries, for which data adequate quality were available, we...

Favorable testicular cancer mortality-to-incidence ratios (MIRs) are associated with health care disparities, including expenditures, but the trends of MIR and disparity remain unclear. We evaluated changes in as difference between 2012 2018, termed delta (δMIR). Health expenditures human development index (HDI) were obtained from World Organization Human Development Report Office United Nations Programme. The association variables was analyzed by Spearman’s rank correlation coefficient. A...

Tuberous sclerosis complex (TSC) is a rare disease that causes multisystem benign neoplasm, induced by dysregulation of the mammalian target rapamycin pathway (mTOR). This study aimed to examine effects continuous low-dose everolimus, potent and selective inhibitor mTOR, on treatment TSC-associated renal angiomyolipoma (AML). Between July 2013 August 2017, 11 patients with TSC-AML were enrolled for an everolimus therapy protocol. An oral dose starting at 2.5 mg daily was gradually increased...

Prostate cancer (PCa) is a common malignancy in males and has relatively slower progression than other cancers. Our goal was to evaluate the clinical role of SPARC (secreted protein acidic cysteine rich, osteonectin), cwcv, kazal-like domains' proteoglycan 1 (SPOCK1) PCa. SPOCK1 expression studied through immunohistochemical staining specimens from 71 patients with The correlation between clinicopathological features quantitatively analyzed. We used Kaplan-Meier analysis Cox proportional...

To investigate the effects of concomitant injections botulinum toxin-A (BoNT-A) into detrusor and external urethral sphincter muscles in suprasacral spinal cord injured patients with overactivity dyssynergia.An open treatment trial pre- posttreatment evaluations.Male injury (n = 20) neurogenic dyssynergia who emptied their bladder by reflex voiding were unwilling to increase frequency intermittent catheterization.Cystoscopic guidance 200 U BoNT-A muscle 100 applied. The urodynamic...