A5012427228- Leprosy Research and Treatment
- Infectious Diseases and Tuberculosis
- Ocular Diseases and Behçet’s Syndrome
- Peripheral Nerve Disorders
- Peripheral Neuropathies and Disorders
- Hematological disorders and diagnostics
- Mycobacterium research and diagnosis
- Botulinum Toxin and Related Neurological Disorders
- Acne and Rosacea Treatments and Effects
Universidade Federal do Estado do Rio de Janeiro
2022-2024
Fundação Oswaldo Cruz
2022-2024
Hospital Universitário Pedro Ernesto
2023-2024
Universidade do Estado do Rio de Janeiro
2023-2024
Hansen’s disease, or leprosy, is a disease characterized by dermatological and neurological disorders. A neural form also exists, in which peripheral neuropathy occurs the absence of skin lesions. However, cases leprosy that involve central nervous system proximal nerves are rare literature. We describe case an oligosymptomatic patient diagnosed with involvement nerves, dorsal root ganglion, cervical spinal cord atypical presentation disease. Through complementary examinations nerve...
Leprosy reactions are complications that can occur before, during, or after multidrug therapy (MDT) and considered a major cause of nerve damage. Neuritis is an inflammatory process causes function impairment associated with pain tenderness along the nerve. be found in both type 1 2 may also sole manifestation leprosy reaction. The objective this study to describe incidence its association neuropathic pure neural (PNL) patients.We selected 52 patients diagnosed PNL 67 other clinical forms...
Pure Neural Leprosy (PNL) is a rare clinical form of leprosy in which patients do not present with the classical skin lesions but have high burden disability associated disease. Clinical characteristics and follow up PNL are still poorly described literature.This paper aims to describe clinical, electrophysiological histopathological patients, as well their evolution after multidrug therapy (MDT).Fifty-two were selected. Clinical, nerve conduction studies (NCS), anti-PGL-1serology evaluated....
Leprosy is caused by multiple interactions between Mycobacterium leprae (M. leprae) and the host's peripheral nerve cells. M. primarily invades Schwann cells, causing damage consequent development of disabilities. Despite its long history, pathophysiological mechanisms in lepromatous pole leprosy remain poorly understood. This study used findings 18F-FDG PET/CT on nerves eight patients to evaluate degree glucose uptake compared them with clinical, electrophysiological, histopathological...
Leprosy is still a prevalent disease in Brazil, representing 93% of all occurrences the Americas. neuropathy one most worrying manifestations disease. Acute usually occurs during reaction episodes and called neuritis. Twenty-two leprosy patients were included this study. These had neural pain associated with ulnar sensory neuropathy, or without adjunct motor involvement. The neurological picture began within thirty days clinical evaluation. underwent nerve conduction study demyelinating...
One of the main manifestations leprosy is peripheral nerve impairment. Early diagnosis and treatment are important to reduce impact neurological impairment, which can cause deformities physical disabilities. Leprosy neuropathy be acute or chronic, neural involvement occur before, during, after multidrug therapy, especially during reactional episodes when neuritis occurs. Neuritis causes loss function in nerves irreversible if left untreated. The recommended corticosteroids, usually through...
Introduction Pure Neural Leprosy (PNL) is a form of this long time known disease that affects only the peripheral nervous system. Since it rare disease, its pathophisiology still poorly understood. Objective Describe cytokines profile in patients with PNL. Methods 30 Patients diagnosed PNL Souza Araujo Outpatient Clinic and evaluated were selected. They by neurologists after nerve biopsy. Serum levels IL-1 β, IL-6, IL-10, IL-17, TNF, CCL-2/MCP-1, IFN-ϒ, CXCL-10/IP-10 TGF-β evaluates at...