A5005043772- Arsenic contamination and mitigation
- Autism Spectrum Disorder Research
- Gestational Diabetes Research and Management
- Heavy Metal Exposure and Toxicity
- Pregnancy and preeclampsia studies
- Alzheimer's disease research and treatments
- Virology and Viral Diseases
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Selenium in Biological Systems
- Heavy metals in environment
- Metabolomics and Mass Spectrometry Studies
- Retinoids in leukemia and cellular processes
- Extracellular vesicles in disease
- Cholinesterase and Neurodegenerative Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Connective Tissue Growth Factor Research
- Studies on Chitinases and Chitosanases
- Advanced Glycation End Products research
- Electrochemical Analysis and Applications
- S100 Proteins and Annexins
- Diabetes and associated disorders
- Vitamin C and Antioxidants Research
- Chronic Kidney Disease and Diabetes
Shenzhen University
2022-2025
Diabetic nephropathy (DN) has become the main cause of end-stage renal disease worldwide, causing significant health problems. Early diagnosis is quite inadequate. To screen urine biomarkers DN and explore its potential mechanism, this study collected from 87 patients with type 2 diabetes mellitus (which will be classified into normal albuminuria, microalbuminuria, macroalbuminuria groups) 38 healthy subjects. Twelve individuals each group were then randomly selected as screening cohort for...
Genetic heterogeneity poses a challenge to research and clinical translation of autism spectrum disorder (ASD). In this study, we conducted plasma proteomic metabolomic study children with ASD without risk genes (de novo mutation) controls explore the impact genetic on search for biomarkers ASD. terms profiles, groups carrying those not de mutation tended cluster overlap, integrating them yielded differentially expressed proteins differential metabolites that effectively distinguished from...
Arsenic (As) is a widespread metalloid and human carcinogen found in the natural environment, multiple toxic effects have been shown to be associated with As exposure. can accumulated spleen, largest peripheral lymphatic organ, long-term exposure lead splenic injury. In this study, Sprague-Dawley (SD) rat model of As-poisoned was established, aiming explore molecular mechanism As-induced immune injury through combined analysis proteomics metabolomics rats' spleen. After feeding rats diet (50...
Abstract Alzheimer’s disease (AD) is a multifactorial neurodegenerative that lacks convenient and accessible peripheral blood diagnostic markers effective drugs. Metabolic dysfunction one of AD risk factors, which leaded to alterations various metabolites in the body. Pathological changes brain can be reflected are expected explain mechanisms or candidate biomarkers. The aim this study was investigate targeted within mouse model, with purpose exploring mechanism potential Targeted...
<title>Abstract</title> Arsenic (As) exposure is a major public health challenge worldwide. Much evidence suggests that As can cause disturbances in trace element balance the body. However, there are few reports on effect of levels central nervous system (CNS). We conducted an experiment to detect 19 elements hippocampus and cortex arsenic-exposed rats by inductively coupled plasma mass spectrometry. The results showed were significantly higher than those control group, hippocampus. In Cd,...
<title>Abstract</title> Gestational diabetes mellitus (GDM) is the first spontaneous hyperglycemia during pregnancy. Early diagnosis and intervention are important for management of disease. This study compared analyzed proteins total plasma exosomes (T-EXO) placental-derived (PLAP-EXO) in pregnant women who subsequently developed GDM (12–16 weeks), patients (24–28 weeks) their corresponding controls to investigate pathogenesis biomarkers associated with exosomes. The exosomal were extracted...
Gestational diabetes mellitus (GDM) is the first spontaneous hyperglycemia during pregnancy. Early diagnosis and intervention are important for management of disease. This study compared analyzed proteins total plasma exosomes (T-EXO) placental-derived (PLAP-EXO) in pregnant women who subsequently developed GDM (12-16 weeks), patients (24-28 weeks) their corresponding controls to investigate pathogenesis biomarkers associated with exosomes. The exosomal were extracted studied by proteomics...