A5056127775- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Meningioma and schwannoma management
- Advanced MRI Techniques and Applications
- Management of metastatic bone disease
- Radiation Dose and Imaging
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- MRI in cancer diagnosis
- Head and Neck Surgical Oncology
- Multiple and Secondary Primary Cancers
- Trigeminal Neuralgia and Treatments
- Adrenal and Paraganglionic Tumors
- Ear and Head Tumors
- Cutaneous Melanoma Detection and Management
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
The Maria Sklodowska-Curie National Research Institute of Oncology
2013-2024
Nagoya City University
2019
Yonsei University
2019
Technical University of Munich
2017
Koblenz University of Applied Sciences
2017
Centrum Onkologii
2013-2017
Klinikum rechts der Isar
2017
The aim of this study was to evaluate CyberKnife-based radioablation as a salvage treatment for prostate cancer postirradiation relapses based on group patients disqualified from available conventional methods treatment. Thirty-eight were treated with fraction dose varying 5.5 10 Gy (median 7.35) total 18 36.25 36.25). In all, 55.3% had androgen deprivation therapy during time. Nine oligometastases in the follow-up varied 1.6 46.4 months (mean 19.7, median 14.4). 92.6% 97.4% no...
The aim of the study was to evaluate effectiveness and toxicity CyberKnife (CK) stereotactic radiosurgery (SRS) ablative radiation therapy (SABR) patients with prostate cancer bone metastases.Analysis prognostic predictive factors also performed.Material consisted 51 71 oligometastases treated using CK SRS/SABR.In half single lesion treated, in 2-5 lesions.Median PSA concentration at time metastasis detection 5.75 ng/ml.Total dose 6-45Gy (median 20) delivered 1-5 fractions 6-15 Gy...
The aim of this study was to evaluate the effectiveness CyberKnife-based stereotactic ablative radiotherapy on prostate cancer lymph node metastases. Our material consisted 18 patients with 31 metastatic nodes irradiated between 2011 and 2014 using radiotherapy. Patients were fraction dose varied from 6 15 Gy (median 10), total 24 45 30). Irradiated size 0.4 4.0 cm. In all, 9 had single metastasis metastases 2 4 nodes. Prostate-specific antigen concentration before 0.01 15.58 (mean 6.97;...
The images of a patient with acromegaly, who previously underwent operation for pituitary adenoma, were obtained. MRI scan showed mass in the right cavernous sinus, biochemical test results positive presence hormonally active adenoma. was scheduled CyberKnife radiotherapy. Radiotherapy planning carried out using and PET/CT somatostatin analog 68Ga DOTATATE. latter radiopharmaceutical uptake on adenomatous residual mass. Contours drawn PET summed up to devise radiotherapy plan. treated total...
Bony metastases from prostate cancer are often associated with severe pain. Standard palliative radiotherapy does not provide full analgesic effect in most patients. CyberKnife radiosurgery allows for the precise treatment of small lesions, such as metastases, located bones or near critical organs. object. Pilot study effectiveness patients bony oligometastases cancer.CyberKnife was used 48 cases bone (32 patients). Patients were treated fraction doses 6 to 15 Gy, delivered 1-3 fractions, a...
Objectives: To evaluate the tolerance and effectiveness of stereotactic ablative radiotherapy (SABR) applied in treatment low intermediate risk (LR & IR) prostate cancer patients (PCP) provide an evaluation level group impact on results. In addition, androgen deprivation therapy (ADT) usage prostatic specific antigen (PSA) decline after SABR were assessed. Material Methods: A total 400 PCP (213 LR 187 IR, including T2c) irradiated with a CyberKnife using fd 7.25 Gy to TD 36.25 Gy. At start...
Introduction Prostrate cancer (PC) is one of the most common malignancies and frequently treated with an 8-week course radiotherapy.CyberKnife (CK) based radioablation enables completion therapy within 5-9 days.The aim this study evaluation effectiveness tolerance CyberKnifebased in prostate patients. Material methods 200 PC patients (94 low risk [LR], 106 intermediate [IR]) underwent CK irradiation every other day (fraction dose [fd] 7.25 Gy, total [TD] 36.25 time 9 days).PSA varied from...
Prostate Imaging-Reporting and Data System (PI-RADS) has been widely implemented as a diagnostic tool for significant prostate cancer (PCa); less is known about its prognostic value, especially in the setting of primary radiotherapy. We aimed to analyze association between PI-RADS v. 2.1 classification risk metastases, based on group 152 patients treated with ultra-hypofractionated stereotactic CyberKnife radiotherapy localized low or intermediate risk-group cancer. found that all distant...
Stereotactic ablative radiotherapy is a very promising approach for the treatment of patients with prostate cancer. The aim this study was to evaluate clinical tolerance, effectiveness, patterns failure, and attempt define predictive factors based on our experience.The cohort consists 264 low-risk 236 intermediate-risk consecutive treated at one institution. Prostate-specific antigen (PSA), adverse effects, androgen deprivation therapy (ADT) usage were noted.Median follow-up 31.3 months....
The aim of this study was to report individual surface mould multi-catheter high-dose-rate (IMM HDR) application as a salvage treatment for head and neck angiosarcoma patient, previously treated with surgery followed by external beam radiotherapy.A 74-year-old male reported our center an uncommon malignant neoplasm blood vessels. patient qualified wide local excision (WLE) tumor simultaneous reconstruction using free-flap collected from the patient's thigh. After surgery, adjuvant...
Frame-based stereotactic radiosurgery (SRS) has an established role in the treatment of tremor patients with Parkinson’s disease (PD). The low numbers studies frameless approaches led to our prospective phase 2 open-label single-arm clinical trial (NCT02406105), which aimed evaluate safety and efficacy CyberKnife SRS. Twenty-three PD were irradiated on area thalamic ventral nuclei complex gradually increasing doses 70 105 Gy delivered a single fraction. After SRS, monitored for severity...
A cohort of 650 patients treated for localized prostate cancer (PCa) with CyberKnifeTM ultra-hypofractionated radiotherapy between 2011 and 2018 was retrospectively analyzed in terms survival, patterns failure, outcomes second-line definitive salvage therapies. The analysis performed using survival including the Kaplan-Meier method Cox regression analysis. At a median follow-up 49.4 months, main pattern failure local-regional (7.4% low-, 13% intermediate/high-risk group at five years),...
Due to somatostatin receptor expression in meningiomas, PET with analogs appears be useful radiotherapy treatment planning. We report the case of a 63-year-old man diagnosed meningioma left frontal lobe 2011. He underwent total tumor excision (pathology was atypical WHO 2) and radiotherapy, but one year after completion treatment, he complained about diplopia upper eyelid ptosis. The MRI showed new parasagittal lesion patient received stereotactic radiotherapy. Few weeks later, two lesions...
The purpose of this study was to evaluate the efficacy and safety applying CyberKnife (CK) radiosurgery in patients with spinal metastases.Twenty-eight vertebral metastases treated using CK system were included study. Eleven suffered from pain, 1 case neurological symptoms observed. remaining free clinical metastatic disease. doses applied ranged between 8 40 Gy delivered 4 fractions 8-15 Gy.In first follow-up evaluation (mean 4.5 months after treatment), pain stable 5 evaluable cases 3...
Given tissue inhomogeneity and lack of backscatter media, superficial brachytherapy necessitates more accurate dosimetry than TG-43 formalism. However, the introduction modern model-based dose calculation algorithms into clinical practice should be carefully evaluated. The aim this work was to compare distributions calculated with advanced collapsed cone engine (ACE) for individual multi-catheter moulds, investigate impact target size bolus differences between plans.Eleven treatment plans...
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Abstract Introduction Radiotherapy (RT) in patients with cardiac implantable electronic devices (CIED) is performed increasingly more frequently. Currently, there no evidence, whether RT subcutaneous cardioverter-defibrillator (sICD) feasible and safe. Purpose To perform the first in-vitro analyses using a model of left lung cancer treated stereotactic body radiotherapy (SBRT) presence an sICD. Methods Three functional sICDs explanted from following heart transplant underwent RT. In one...
The accumulated dose from sequential treatments of metachronous non-melanoma skin cancer can be assessed using image registration, although guidelines for selecting the appropriate algorithm are lacking. This study shows impact rigid (RIR), deformable (DIR) and structure-based (SDIR) algorithms on dose. DIR increased: maximum (39.2 Gy vs 9.4 Gy), to 0.1 cm
Purpose: The purpose of this work was to evaluate limits and capabilities in the transit dosimetry software for use with TomoTherapy system by irradiating a heterogeneous phantom. Methods: Helical plan created using CIRS phantom (model 062M) nine various tissue equivalent inserts (lung inhale 0.2 g/cm3, lung exhale 0.5 adipose 0.96 breast 0.99 water 1.01 muscle 1.06 liver 1.07 trabecular bone 1.16 dense 1.53 g/cm3). Targets were contoured within every insert. scanned 50 cm field view 3 mm...
Abstract New capabilities of biomedical accelerators allow for very precise depositing the radiation dose and imaging verification during therapy. In addition, computer algorithms calculating distributions are taking into account increasing number physical effects. Therefore, administration high fractionation, which is consistent with radiobiology used in oncology, becomes safer safer. Stereotactic radiosurgery (SRS), irradiation fractionation increasingly widespread use radiotherapy...