About
Contact & Profiles
A5063882906
Research Areas
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
Garvan Institute of Medical Research
2023
The Kinghorn Cancer Centre
2023
Aberrant AKT activation occurs in a number of cancers, metabolic syndrome, and immune disorders, making it an important target for the treatment many diseases. To monitor spatial temporal activity live setting, we generated Akt-FRET biosensor mouse that allows longitudinal assessment using intravital imaging conjunction with image stabilization optical window technology. We demonstrate sensitivity various cancer models verify its suitability to response drug targeting spheroid organotypic...
10.1126/sciadv.adf9063
article
EN
cc-by-nc
Science Advances
2023-04-26
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