A5059441160- Enzyme Catalysis and Immobilization
- Ionic liquids properties and applications
- Electrochemical sensors and biosensors
- Analytical Chemistry and Chromatography
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Microbial Metabolic Engineering and Bioproduction
- Protein Interaction Studies and Fluorescence Analysis
- Surfactants and Colloidal Systems
- Invertebrate Immune Response Mechanisms
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Seaweed-derived Bioactive Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- HIV/AIDS drug development and treatment
- Electrochemical Analysis and Applications
- Enzyme Production and Characterization
- Antioxidant Activity and Oxidative Stress
- Cultural Heritage Materials Analysis
- Peptidase Inhibition and Analysis
- Chemical and Physical Properties in Aqueous Solutions
- Aquaculture disease management and microbiota
- Click Chemistry and Applications
- Building materials and conservation
- Pharmacology and Obesity Treatment
Bulgarian Academy of Sciences
2016-2025
Institute of Organic Chemistry with Centre of Phytochemistry
2016-2025
Betulinic acid (BA) is a natural pentacyclic triterpene with diverse biological activities. However, its low water solubility limits pharmaceutical application. The conversion of pharmaceutically active molecules into ionic liquids (ILs) promising strategy to improve their physicochemical properties, stability, and/or potency. Here, we report the synthesis and characterization 15 novel ILs containing cation ethyl ester polar, non-polar, or charged amino [AAOEt] an anion BA. Except for...
The conversion of betulinic acid (BA) to organic salts is a strategic approach modulate its physicochemical properties and biological activity. In our previous study, we demonstrated the enhanced cytotoxicity certain amino ethyl ester betulinates ([AAOEt][BA]) compared BA against hormone-dependent breast cancer cells (MCF-7). this extended investigation evaluate cytotoxic response thermodynamic hormone-independent (MDA-MB-231) following 72 h treatment with same series betulinates. Our data...
This review explores the emerging potential of amino acid-based ionic liquids (AA ILs) in various (bio)applications, emphasizing their unique properties and versatility. It provides a comprehensive analysis recent advancements, covering applications drug delivery, catalysis, environmental remediation, biotechnology. The also offers an overview synthetic methods for preparing AA ILs, highlighting both traditional innovative approaches, examines key physicochemical properties—such as...
Background/Objectives: The treatment of diabetic foot ulcers (DFU) is a challenging medical problem extreme clinical and social importance, as consequence the emerging antibiotic resistance decreased quality life patients due to impaired wound healing. One current trends in world science search for biologically active substances derived from living organisms. Biologically peptides snail mucus attract considerable scientific interest because their pleiotropic pharmacological properties. aim...
The development of ionic liquids based on active pharmaceutical ingredients (API-ILs) is a possible solution to some the problems solid and/or hydrophobic drugs such as low solubility and bioavailability, polymorphism an alternative route administration could be suggested compared classical drug. Here, we report for first time synthesis detailed characterization series ILs containing cation amino acid esters anion ketoprofen (KETO-ILs). affinity binding mode KETO-ILs bovine serum albumin...
This is the first study on interactions of ionic liquids with large metalloproteins, in particular hemocyanins (Hcs).
(1) Background: The aim of the work is evaluation in vitro antiproliferative and pro-apoptotic activity four benzimidazole derivatives containing colchicine-like catechol-like moieties with methyl group substitution ring against highly invasive breast cancer cell line MDA-MB-231 their related impairment tubulin dynamics. (2) Methods: was assessed MTT assay. Alterations polymerization were evaluated an assay a docking analysis. (3) Results: All showed time-dependent cytotoxicity IC
1H-benzimidazol-2-yl hydrazones with varying hydroxy and methoxy phenyl moieties were designed. Their effect on tubulin polymerization was evaluated in vitro porcine tubulin. The compounds elongated the nucleation phase slowed down comparably to nocodazole. possible binding modes of explored by molecular docking at colchicine site. anticancer activity against human malignant cell lines MCF-7 AR-230, as well normal fibroblast cells 3T3 CCL-1. demonstrated a marked antineoplastic low...
In recent years, numerous studies have shown that conversion of conventional drugs in ionic liquid (IL) formulation could be a successful strategy to improve their physicochemical properties or suggest new route administration. We report the synthesis and detailed characterization eight salicylic acid-based ILs (SA-ILs) containing cation non-polar aromatic amino acid esters. Using vitro assays, we preliminary evaluated therapeutic potency novel SA-ILs. observed SA into liquids led decrease...
The present study focused on the characterization of art materials and degradation processes in exterior (exonarthex) mural paintings main church Nativity Virgin Rila monastery, Bulgaria, which is believed to be last large-scale example Eastern Orthodox wall painting. For first time used create a unique colourful polychrome decoration outer gallery possible products, caused by atmospheric influence - permanent exposure open air moisture were revealed multi-technique approach. mineral...
A new set of experimental kinetic data on the hydrolysis a series phenylacetyl p-substituted anilides catalyzed by penicillin G acylase from Escherichia coli (PGA) is presented in this article. The Hammett plot log(k(cat,R)/k(cat,H)) versus sigma(p) (-) has three linear segments, which distinguishes enzyme other N-terminal nucleophile hydrolases for are available. Three amino acids vicinity catalytic SerB1 (AsnB241, AlaB69, and GlnB23) were included quantum mechanical model. stable...
Abstract The catalytic efficiency of a lipase from Bacillus stearothermophilus MC7 (lipase MC7) was evaluated in acidolysis tripalmitin with oleic acid to yield dioleoylpalmitoylglycerol, structured triglyceride used health food. immobilized enzyme exhibits good operational thermostability half‐life 50 days at 60 °C solvent‐free system. degree conversion exceeded 50% after 48 h. side reaction hydrolysis suppressed. However, the monosubstituted product prevalent mixture. Tested broad range...