A5101924359- Carcinogens and Genotoxicity Assessment
- Cancer, Hypoxia, and Metabolism
- Fatty Acid Research and Health
- Cancer, Lipids, and Metabolism
- Effects and risks of endocrine disrupting chemicals
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- DNA Repair Mechanisms
- Child Nutrition and Water Access
- Retinal Development and Disorders
- Health, Education, and Cultural Studies
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- Social Sciences and Policies
- Animal Genetics and Reproduction
- Chromosomal and Genetic Variations
- Immunotherapy and Immune Responses
- Iron Metabolism and Disorders
- Mitochondrial Function and Pathology
- Health and Conflict Studies
- Pluripotent Stem Cells Research
- Neuroscience and Neuropharmacology Research
- Immune responses and vaccinations
- Adipose Tissue and Metabolism
- Clinical Nutrition and Gastroenterology
Universidad Autónoma Metropolitana
1995-2023
Centro de Biología Molecular Severo Ochoa
2020
Universidad Autónoma de Madrid
2020
University of California, Santa Cruz
2014
It is controversial whether mitochondrial dysfunction in skeletal muscle the cause or consequence of metabolic disorders. Herein, we demonstrate that vivo inhibition ATP synthase alters whole-body lipid homeostasis. Mice with restrained activity presented intrafiber droplets, dysregulation acyl-glycerides, and higher visceral adipose tissue deposits, poising these animals to insulin resistance. This energy crisis increases lactate production, prevents fatty acid β-oxidation, forces...
There are numerous functional types of retinal ganglion cells (RGCs), each participating in circuits that encode a specific aspect the visual scene. This specificity is derived from distinct RGC morphologies and selective synapse formation with other cell types; yet, how these properties established during development remains unclear. Islet2 (Isl2) LIM-homeodomain transcription factor expressed developing retina, including approximately 40% all RGCs, has previously been implicated subtype...
Summary The aim of this study was to determine if the distribution in vivo CD4+CD45RA+/CD45RO− (naive), CD4+CD45RA+/CD45RO+ (Ddull) and CD4+CD45RO+ (memory) lymphocytes differs malnourished infected well-nourished children. expression CD45RA (naive) CD45RO antigens on CD4+ analysed by flow cytometry a prospectively followed cohort 15 infected, 12 10 uninfected Malnourished children showed higher fractions Ddull cells (11·4 ± 0·7%) lower memory (20·3 1·7%) than group (8·8 0·8 28·1 1·8%,...
Summary The mechanisms involved in impaired immunity malnourished children are not well understood. CD4+ CD62L– and CD8+ CD28– do express the naive cell markers CD62L CD28, suggesting that they function as effector T cells. Using a flow cytometry-based analysis we examined proportions of subsets well-nourished infected (WNI) (MNI) children. Here report WNI had higher percentage (11·1 ± 1·0) D28– (40·2 5·0) than healthy (6·5 1·0 23·9 4·8) MNI (7·4 1·1 23·1 6·2, respectively) (P < 0·5)....
The aim of this study was to assess DNA repair capacity in lymphocytes children with protein calorie malnutrition using the single-cell gel electrophoresis (comet) assay. Repair assessed by estimating relative decrease migration length 5, 15, 30, and 60 min after hydrogen peroxide treatment, three groups children: well-nourished (WN), infected (WN-I), malnourished (MN-I). In addition, evaluated all before treatment. Comparison mean lengths observed WN WN-I showed significant differences at...
Abstract The purpose of this ex vivo study was to determine if severe malnutrition increases the frequency micronuclei in spleen lymphocytes experimentally malnourished rats during lactation. Micronucleus frequencies were analyzed binucleate cells produced by cytokinesis block method. overall micronucleus significantly higher from (21.3%‰) as compared that observed control (11.5%‰). number with more than one also controls (3.1%‰ vs. 1.2%‰). These results indicate produces cellular damage...
Abstract In vitro response of T (CD3+, CD4+ and CD8+), B (CD19+) NK (CD56+) peripheral blood lymphocytes to the mitogens PHA, PWM IL-2, respectively, were compared in three groups children: non-infected well-nourished, well-nourished infected malnourished children. This was measured by analysing expression early activation antigen CD69 three-color flow cytometry. All lymphocyte subsets children showed impaired capability, as percentages CD3+CD69+, CD4+CD69+ CD8+CD69+ lower than those...
In a previous study, we have identified set of conserved spermatogenic genes whose expression is restricted to testis and ovary that are developmentally regulated. One these genes, the transcription factor Mael, has been reported play an essential role in mouse spermatogenesis. Nevertheless, Mael oogenesis not defined. order analyse oogenesis, this gene was blocked during early vitro using RNAi technology. addition, differentiation embryonic stem cells (ESC) into germ analysed. Results show...