A5063288749- Carcinogens and Genotoxicity Assessment
- Child Nutrition and Water Access
- Effects and risks of endocrine disrupting chemicals
- DNA Repair Mechanisms
- Sperm and Testicular Function
- Iron Metabolism and Disorders
- Bat Biology and Ecology Studies
- Heavy Metal Exposure and Toxicity
- Birth, Development, and Health
- Trace Elements in Health
- Clinical Nutrition and Gastroenterology
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Hormonal and reproductive studies
- Reproductive Biology and Fertility
- Immune Response and Inflammation
- Cell death mechanisms and regulation
- Agricultural and Food Production Studies
- Pomegranate: compositions and health benefits
- Toxic Organic Pollutants Impact
- Microbial Metabolites in Food Biotechnology
- Water-Energy-Food Nexus Studies
- Microencapsulation and Drying Processes
- Reproductive tract infections research
- Aluminum toxicity and tolerance in plants and animals
Universidad Autónoma Metropolitana
2015-2025
Universidad Autónoma del Estado de México
2016
Summary The aim of this study was to determine if the distribution in vivo CD4+CD45RA+/CD45RO− (naive), CD4+CD45RA+/CD45RO+ (Ddull) and CD4+CD45RO+ (memory) lymphocytes differs malnourished infected well-nourished children. expression CD45RA (naive) CD45RO antigens on CD4+ analysed by flow cytometry a prospectively followed cohort 15 infected, 12 10 uninfected Malnourished children showed higher fractions Ddull cells (11·4 ± 0·7%) lower memory (20·3 1·7%) than group (8·8 0·8 28·1 1·8%,...
Malnutrition continues to be a major public health problem throughout the developing world. Nutritional deficiencies may most common cause of secondary immunodeficiency states in humans. It has been suggested that nutritional imbalances can induce apoptosis variety cell types. The purpose this study was examine effect severe malnutrition on subsets and frequency spontaneous and/or dexamethasone-induced death vivo thymus spleen from severely malnourished, lactating rats. Apoptosis estimated...
Infertility is increasingly recognized as being closely linked to obesity in humans. The successful production of fertile spermatozoa requires adequate spermatogenesis within the testis and proper maturation through epididymis. This study aimed evaluate impact body adiposity on male fertility, focusing sperm parameters, epididymal maturation, capacitation Wistar rats. Male rats were randomized into three dietary groups over four weeks: a control group receiving less than 4% lard, regular...
Sperm maturation involves changes in plasma membrane glycosylation for fertilization. Cadmium (Cd) exerts a negative effect by disrupting testicular and epididymal function, altering antioxidant activity. Zinc (Zn) is an essential element known its properties, role testosterone synthesis, support of spermatogenesis. However, on sperm glycosylation, as well endocrine activity, after exposure to Cd has remained unexplored. This study evaluated the impact Zn activity Cd-exposed rats. Four...
Summary The mechanisms involved in impaired immunity malnourished children are not well understood. CD4+ CD62L– and CD8+ CD28– do express the naive cell markers CD62L CD28, suggesting that they function as effector T cells. Using a flow cytometry-based analysis we examined proportions of subsets well-nourished infected (WNI) (MNI) children. Here report WNI had higher percentage (11·1 ± 1·0) D28– (40·2 5·0) than healthy (6·5 1·0 23·9 4·8) MNI (7·4 1·1 23·1 6·2, respectively) (P < 0·5)....
Malnutrition is distributed widely throughout the world and a particular problem in developing countries. Laboratory animals have been very useful studying effects of varying levels malnutrition because non-nutritional factors that affect humans may be controlled. The objective present study was to determine moderate severe on lymphocyte proportions activation markers T cells experimentally malnourished rats during lactation by flow cytometry. Lower absolute (total) relative (%) numbers CD3+...
The aim of this study was to assess DNA repair capacity in lymphocytes children with protein calorie malnutrition using the single-cell gel electrophoresis (comet) assay. Repair assessed by estimating relative decrease migration length 5, 15, 30, and 60 min after hydrogen peroxide treatment, three groups children: well-nourished (WN), infected (WN-I), malnourished (MN-I). In addition, evaluated all before treatment. Comparison mean lengths observed WN WN-I showed significant differences at...
The FA/BRCA pathway repairs DNA interstrand crosslinks. Mutations in this cause Fanconi anemia (FA), a chromosome instability syndrome with bone marrow failure and cancer predisposition. Upon damage, normal FA cells inhibit the cell cycle progression, until G2/M checkpoint is turned off by recovery, which becomes activated when damage has been repaired. Interestingly, highly damaged seem to override checkpoint. In study we explored Boolean network model key experiments whether recovery...
Severe malnutrition is widely distributed throughout the world, showing a high prevalence in developing countries. Experimental animal models have been useful to study effects of at different levels and ages. Apoptosis well recognised process cell death occurring under several physiological pathological conditions. It represents principal mechanism involved selection thymus. Thymocyte apoptosis induction by dexamethasone one best characterised experimental programmed death. The aim present...
The combination of trimethoprim and sulfamethoxazole (TMP-SMX) is a widely used drug. In spite this, there are few reports on its genotoxicity, the results controversial. Severe malnutrition complex condition that increases susceptibility to infections. Consequently, drugs extensively in cases. Experimental animal models have been study effects malnutrition. Neonatal rats were experimentally malnourished (UN) during lactation. UN weighed 51.1% less than well-nourished (WN) controls had lower...
<i>Objectives:</i> There is growing evidence of the relationship between sleep and immune response. Studies aimed at elucidating function rapid eye movement (REM) have found it difficult to separate effects due REM deprivation stress produced by procedure. It has been claimed that immobilization main stressor animals face during process. In this study, we analyzed short-term (24 h) long-term (240 on distribution lymphocyte subsets in peripheral blood rats. addition, these were...
Abstract Severe malnutrition is widely distributed throughout the world and exhibits a high prevalence in developing countries. Experimental models have been useful to study effects of at early ages. The purpose this was determine if severe induced during lactation rats increases DNA damage spleen, peripheral blood, bone marrow cells, as well isolated lymphocytes or lymphoid cells from same tissues. These were obtained malnourished weaning (21 days age). estimated by using alkaline single...
The purpose of this study was to determine if peripheral blood lymphocytes from malnourished children with gastrointestinal or respiratory bacterial infection show increased frequencies Mitomycin C (MMC)-induced micronuclei as compared well-nourished, infected children. results indicate that cells malnourished, had greater chromosome damage. This may such would be more susceptible environmental damage and malignant transformation. Micronucleus were analyzed in binucleate produced by the...
Abstract The purpose of this ex vivo study was to determine if severe malnutrition increases the frequency micronuclei in spleen lymphocytes experimentally malnourished rats during lactation. Micronucleus frequencies were analyzed binucleate cells produced by cytokinesis block method. overall micronucleus significantly higher from (21.3%‰) as compared that observed control (11.5%‰). number with more than one also controls (3.1%‰ vs. 1.2%‰). These results indicate produces cellular damage...
Abstract Infectious disease and malnutrition in children are public health problems developing countries. Malnutrition is associated with higher levels of DNA damage, this increased damage could be due to different factors, including the possibility that cells from malnourished more susceptible environmental damage. The aim present study was evaluate susceptibility lymphocytes induced by antibiotics using comet assay. same group infected were studied before after a treatment period, compared...
Abstract The bat Corynorhinus mexicanus provides an interesting experimental model for the study of epididymal sperm maturation because after spermatogenesis and regression testes, this stores in cauda several months. Earlier research conducted by our group suggested that species must be completed caudal region epididymis. One major signal transduction events during is tyrosine phosphorylation proteins. aim present was to comparatively evaluate spermatozoa obtained from caput, corpus...
Background/Aim: Undernutrition is a serious health problem prevalent in poor countries, affecting millions of people worldwide, especially young children, pregnant women, and sick elderly individuals. This condition increases vulnerability to infections, leading widespread use antibiotic treatments undernourished populations. The objective the present study was determine vivo genotoxic cytotoxic effects trimethoprim-sulfamethoxazole (TMP-SMX) treatment according nutritional conditions....
Parabens (PBs) are widely used in the cosmetic, pharmaceutical, and food industries as preservatives of products. Because its great use, humans other organisms highly exposed daily. However, little is known about effect PBs on male infertility. Therefore, aim present study was to evaluate methylparaben (MePB) propylparaben (PrPB), alone or combination, physiological characteristics pig vitro sperm different concentrations (0, 200, 500, 700 μM) for viability, motility, acrosome integrity...
Abstract Severe malnutrition caused by deficiencies in protein, calorie, and micronutrient intake is widely distributed throughout the world a particular problem developing countries. Animal models have been useful for studying effects of under different experimental conditions. In this study, we evaluated effect on frequency spontaneous mitomycin C (MMC)‐induced micronuclei peripheral blood rats measured using flow cytometric analysis technique. Neonatal were experimentally malnourished...