A5058289988- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- RNA Research and Splicing
- Cellular Mechanics and Interactions
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
- Melanoma and MAPK Pathways
- Protein Degradation and Inhibitors
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2022-2025
National Institutes of Health
2022-2025
Abstract Cells undergo tens of thousands DNA-damaging events each day. Defects in repairing double-stranded breaks (DSBs) can lead to genomic instability, contributing cancer, genetic disorders, immunological diseases, and developmental defects. Cohesin, a multi-subunit protein complex, plays crucial role both chromosome organization DNA repair by creating architectural loops through chromatin extrusion. However, the mechanisms which cohesin regulates these distinct processes are not fully...
Ovarian cancer, a significant contributor to cancer-related mortality, exhibits limited responsiveness hormonal therapies targeting the estrogen receptor (ERα). This study aimed elucidate mechanisms behind ERα resistance therapeutic drug Fulvestrant (ICI182780 or ICI). Notably, compared cytoplasmic version, nuclear was minimally degraded by ICI, suggesting mechanism for via protective confines of substructures. Of these substructures, we identified 1.3MDa Megacomplex comprising transcription...
Mutations to the human kinome are known play causal roles in cancer. The regulates numerous cell processes including growth, proliferation, differentiation, and apoptosis. In addition aberrant expression, alternative splicing of cancer-driver genes is receiving increased attention as it could lead loss or gain functional domains, altering a kinase’s downstream impact. present study quantifies changes gene expression isoform ratios metastatic melanoma cells relative primary tumors. We...