A5101649004- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Magnetism in coordination complexes
- Crystallography and molecular interactions
- Carbohydrate Chemistry and Synthesis
- Agricultural pest management studies
- Metal-Catalyzed Oxygenation Mechanisms
- Chemical Synthesis and Analysis
- Combustion and flame dynamics
- Wind Energy Research and Development
- Legume Nitrogen Fixing Symbiosis
- Metal-Organic Frameworks: Synthesis and Applications
- Glycosylation and Glycoproteins Research
- Agricultural Economics and Practices
- Advanced Combustion Engine Technologies
- Asymmetric Synthesis and Catalysis
- Wind and Air Flow Studies
- Agricultural Research and Practices
- Radiative Heat Transfer Studies
- Synthetic Organic Chemistry Methods
- Genetic and Environmental Crop Studies
- Heat and Mass Transfer in Porous Media
- Agricultural Science and Fertilization
- Lanthanide and Transition Metal Complexes
Syngene International (India)
2017-2025
Biocon (India)
2016-2025
Amgen (India)
2025
Jadavpur University
2016-2022
North Carolina State University
2018-2022
Intel (United States)
2021-2022
Institute of Inorganic Chemistry of the Slovak Academy of Sciences
2018-2020
Bidhan Chandra Krishi Viswavidyalaya
2019-2020
Bristol-Myers Squibb (United States)
2016-2017
Bristol-Myers Squibb (India)
2016
The stereoselective formation of 2-endo-substituted hexahydropyrrolo[2,3-b]indoles from 2-substituted tryptamine derivatives, especially tryptophan, is discussed. Parallels are drawn with the related heterocyclic systems, such as hexahydrofurano[2,3-b]benzofurans, in which thermodynamic preference a substituent at 2-position also for endo-configuration. Functionalization tryptophan-derived hexahydropyrroloindoles positions 2-, 3-, and 3a- discussed special emphasis on 2-position, both...
Synthesis of erythro-N-Boc-β-mercapto-l-phenylalanine enables native chemical ligation at phenylalanine. In the form S-ethyldisulfanyl derivative, N-Boc amino acid is used to cap a tetrapeptide generated by Fmoc-SPPS. The with C-terminal thioesters then occurs successfully and followed selective desulfurization benzylic C−S bond. method applied synthesis LYRAMFRANK, thereby establishing compatibility reactive side chains ability ligate other than glycine.
Covalent inhibition of the KRASG12C oncoprotein has emerged as a promising therapeutic approach for treatment nonsmall cell lung cancer (NSCLC). The identification inhibitors typically relied on high-throughput screening (HTS) libraries cysteine-reactive small molecules or attachment warheads to noncovalent binders KRAS. Such approaches have historically been limited in size and diversity that could be effectively screened. DNA-encoded library (DEL) accelerate preparation incredibly large...
The direct syntheses of a β-(1→2)-mannooctaose and β-(1→4)-mannohexaose are reported by means 4,6-O-benzylidene-protected β-mannosyl donors. synthesis the (1→2)-mannan was achieved sulfoxide coupling protocol, whereas (1→4)-mannan prepared using analogous thioglycoside/sulfinamide methodology. In (1→4)-mannan, glycosylation yields stereoselectivities remain approximately constant with increasing chain length, those for consist two groups formation tetra- higher saccharides giving...
The synthesis of d- and l-glycero-α-manno-thioheptopyranosides, protected with 4,6-O-alkylidene-type acetals is described. In glycosylations carried out preactivation the 1-benzenesulfinylpiperidine/trifluoromethanesulfonic anhydride couple, both l-glycero series exhibit excellent β-selectivity a range glycosyl acceptors. contrast, 4,7-O-alkylidene acetal was found not to afford β-selectivity. With 4,6-O-[1-cyano-2-(2-iodophenyl)ethylidene] thioglycoside, obtained in glycosylation reactions,...
N-Alkenyl iminium ions serve as conduits to three-component [4 + 2] cycloaddition reactions accessing structurally and stereochemically diverse piperidine derivatives. These cationic 2-azadienes participate in endo- or exo-selective cycloadditions with electron-rich neutral alkene dienophiles generate a tetrahydropyridinium ion the initial cycloadduct. In situ nucleophilic addition cycloaddition-derived completes coupling sequence affords versatile synthesis of complex piperidines.
Two new cobalt(iii) tetrazolato complexes [Co(L1)(PTZ)(N3)] (1) and [Co(L2)(PTZ)(N3)] (2) {where H2L1 = 2((3-(methylamino)propylimino)methyl)-6-methoxyphenol, H2L2 2((3-(dimethylamino)propylimino)methyl)-6-ethoxyphenol HPTZ 5-(2-pyridyl)tetrazole}, have been synthesized via in situ 1,3-dipolar cycloaddition reaction of 2-cyanopyridine sodium azide the presence cobalt(ii) nitrate hexahydrate respective Schiff bases open atmosphere. The structures both confirmed by single crystal X-ray...
Two dinuclear mixed valence Co(<sc>iii</sc>)/Co(<sc>ii)</sc> complexes have been synthesized and characterized. Both of them show good electrical conductivity, which has rationalized by band gap measurements further confirmed DFT studies.
An expedient synthesis of enantiomerically pure threo-β-hydroxy-α-amino acid derivatives phenylalanine, tyrosine, histidine, and tryptophan is described. The NBS-mediated radical bromination the N,N-di-tert-butoxycarbonyl protected α-amino acids subsequent treatment with silver nitrate in acetone provided trans-oxazolidinones predominantly. Cesium carbonate catalyzed hydrolysis then generated β-hydroxy amino excellent overall yield.
Although considerable progress has already been achieved in the design of wind turbines, available technical designs are not yet adequate to develop a reliable energy converter especially meant for small-scale applications. The Savonius-style turbine appears be particularly promising applications because its simplicity, good starting ability, insensitivity directions, relatively low operating speed, cost and easy installation. However, efficiency is reported inferior as compared other...
Two tetranuclear mixed-valence cobalt(III/II) complexes having the general formula [(μ1,3-N3){CoII(Ln)(μ-O2CC6H4NO2)CoIII(N3)}2]PF6 (where H2L1 and H2L2 are two reduced Schiff base ligands) have been synthesized characterized. The structures of both show cobalt(II) cobalt(III) centers with a distorted octahedral geometry located at inner N2O2 outer O4 cavities ligands, respectively. oxidation states cobalt confirmed by bond valence sum (BVS) calculations. magnetic properties that compounds...
The differences in the molecular and crystalline architectures of two heteronuclear cobalt(<sc>iii</sc>)/sodium complexes were correlated with relative dispositions NH groups them explained using results DFT calculations.
Two cobalt(<sc>ii</sc>) dimers have been synthesized and structurally characterized. Magnetic susceptibility measurements show weak ferromagnetic couplings in both but field-induced slow relaxation of the magnetization at low temperatures only <bold>2</bold>.
A method for the direct stereocontrolled synthesis of d- and l-glycero-β-d-manno-heptopyranosides such as those found in repeating unit O-specific polysaccharide from CNCTC 113/92 LPS (serotype 54) is described. The relies on presence a 4,6-O-benzylidene acetal to effect stereocontrol at anomeric center; configuration C6 (l- or d-glycero) minimal importance.