A5063078592- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Growth Hormone and Insulin-like Growth Factors
- Urologic and reproductive health conditions
- Hidradenitis Suppurativa and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Bladder and Urothelial Cancer Treatments
- Neuroscience of respiration and sleep
- Radiopharmaceutical Chemistry and Applications
- Extracellular vesicles in disease
- Urinary Bladder and Prostate Research
- Estrogen and related hormone effects
- Statistical Methods in Clinical Trials
- Helicobacter pylori-related gastroenterology studies
- Colorectal and Anal Carcinomas
- Neurobiology and Insect Physiology Research
- Retinoids in leukemia and cellular processes
- Ubiquitin and proteasome pathways
- Molecular Biology Techniques and Applications
- Cancer-related gene regulation
- Neuroendocrine Tumor Research Advances
- Anorectal Disease Treatments and Outcomes
Hôpital Lyon Sud
2012-2022
Hospices Civils de Lyon
2010-2022
Centre Léon Bérard
2014-2022
Inserm
2008-2022
Université Claude Bernard Lyon 1
2011-2022
Centre National de la Recherche Scientifique
2011-2022
Centre de Recherche en Cancérologie de Lyon
2014-2022
Molecular Oncology (United States)
2019
Lyon College
2019
Martini-Klinik
2019
Several lines of evidence indicate that constraining intramolecular interactions between transmembrane domains are required to maintain G protein-coupled receptors in an inactive conformation the absence agonist. For glycoprotein hormone receptors, which harbor a long amino-terminal ectodomain responsible for binding, it has been suggested could contribute these negative constraints. To test this hypothesis, we expressed at surface COS-7 cells mutants TSH receptor variable portions replaced...
A 2-gene, urine based molecular test that combines mRNA biomarkers with clinical factors can risk stratify patients for clinically significant prostate cancer. To ensure the generalizability of assay results we optimized and validated model men serum specific antigen less than 10 ng/ml who were undergoing initial biopsy.Urine samples collected from 1,955 The Netherlands, France Germany prior to an biopsy study subjects divided into training validation cohorts. Urinary HOXC6 DLX1 levels...
The efficacy of suppressing TSH secretion with levothyroxine (L-T(4)) in reducing solitary thyroid nodule growth is still controversial. In this prospective multicenter, randomized, double-blind, placebo-controlled trial, 123 patients a single palpable benign were included and randomly allocated to an 18-month treatment L-T(4) or placebo. Individual dose was adjusted allow serum level below 0.3 mIU/liter. Clinical ultrasonographic characteristics assessed before 3, 6, 12, 18 months...
RTHα is a recently discovered resistance to thyroid hormone (RTH) due mutation of THRA, the gene encoding TRα1, receptor. It has been described in few patients with growth retardation, short stature, and low free T4/free T3 (FT4/FT3) ratio.A 27-year-old patient presenting dwarfism FT4/FT3 ratio was investigated.Clinical, biochemical, radiological data were collected. Whole exome sequencing performed her relatives.The exhibited congenital macrocytic anemia severe bone malformation dwarfism,...
Abstract Background Based on the observation of an increased number paralogous genes in teleost fishes compared with other vertebrates and conserved synteny between duplicated copies, it has been shown that a whole genome duplication (WGD) occurred during evolution Actinopterygian fish. Comparative phylogenetic dating this event suggests early on, specifically teleosts. It proposed might have facilitated evolutionary radiation phenotypic diversification fish, notably by allowing sub- or...
The Androgen Receptor (AR) plays a key role in controlling prostate gland homeostasis and contributes to carcinogenesis. identification of its target genes should provide new candidates that may be implicated cancer initiation progression.Transcriptomic experiments chromatin immunoprecipitation were combined identify direct androgen regulated genes. Real-time quantitative PCR (RT-qPCR) analyses performed measure TM4SF1 mRNA levels benign prostatic hyperplasia (BPH) specimens....
It has been suggested that urinary PCA3 and TMPRSS2:ERG fusion tests serum PHI correlate to cancer aggressiveness-related pathological criteria at prostatectomy. To evaluate compare their ability in predicting prostate aggressiveness, (T2) scores were assessed 154 patients who underwent radical prostatectomy for biopsy-proven cancer. Univariate multivariate analyses using logistic regression decision curve performed. All three markers predictors of a tumor volume ≥0.5 mL. Only predicted...
A new technique allows the precise measurement of sulfur isotopes by MC-ICP-MS in a large number small biological samples.
Background Several data favor androgen receptor implication in prostate cancer initiation through the induction of several gene activation programs. The aim study is to identify potential biomarkers for early diagnosis (PCa) among androgen-regulated genes (ARG) and evaluate comparative expression these normal prostate-related androgen-sensitive tissues that do not (or rarely) give rise cancer. Methods ARG were selected non-neoplastic adult human prostatic epithelial RWPE-1 cells stably...
While now recognized as an aid to predict repeat prostate biopsy outcome, the urinary PCA3 (prostate cancer gene 3) test has also been recently advocated initial results. The objective is evaluate performance of in predicting results biopsies and determine whether its incorporation into specific nomograms reinforces diagnostic value. A prospective study included 601 consecutive patients addressed for biopsy. was performed before ≥12-core biopsy, along with standard risk factor assessment....
Pendred syndrome (PS), a recessive disorder caused by mutations in the SLC26A4 (PDS) gene, is associated with deafness and goiter. have also been identified patients exhibiting isolated sensorineural hearing loss without apparent thyroid abnormality (nonsyndromic enlargement of vestibular aqueduct; nonsyndromic EVA). Our aim was to describe systematically thyroidal phenotypes genotypes presenting PS or EVA.Nineteen 23 EVA, aged 5-53 years, were included. They underwent evaluation (physical...
Pseudohypoparathyroidism Ia (PHP Ia) is characterized by resistance to PTH and many other stimuli because of deficiency stimulatory G protein alpha-subunit. To determine the incidence, natural history, mechanism C cell dysfunction in PHP, calcitonin assays were performed six patients with PHP four pseudopseudohypoparathyroidism from three unrelated families. Controls included healthy subjects Ib or hypoparathyroidism. The mean basal level was higher than controls (95.3 +/- 112.7 vs. 3.7 2.4...
The influence of chronic prostatitis on serum PSA level is well known. Whether it also influences potential new biomarkers prostate cancer (PCa) has to be determined. We conducted a prospective study evaluate the effect PCa urinary marker PCA3.Included were 38 patients, mean-aged 37.5 years, with clinical suspicion prostatitis. A simplified version Meares-Stamey four-glass localization test was performed and urine specimens collected for cytological analysis culture. postprostatic massage...
No AccessJournal of UrologyAdult Urology1 Apr 2011Urinary PCA3 Score Predicts Prostate Cancer Multifocality Virginie Vlaeminck-Guillem, Marian Devonec, Marc Colombel, Claire Rodriguez-Lafrasse, Myriam Decaussin-Petrucci, and Alain Ruffion Vlaeminck-GuillemVirginie Vlaeminck-Guillem Department Medical Unit Molecular Oncology Transfer, Faculty Lyon 1 University, Lyon, France Hospices Civils Institute Functional Genomics , DevonecMarian Devonec Urology, ColombelMarc Colombel...
SUMMARY Heterochrony, a difference in developmental timing, is central concept modern evolutionary biology. An example pedomorphosis, retention of juvenile characteristics sexually mature adults, phenomenon largely represented salamanders. The mudpuppy ( Necturus maculosus ) an obligate pedomorphic amphibian, never undergoing metamorphosis. Thyroid hormone induces tissue transformation metamorphosing species and this action mediated by nuclear thyroid (TH) receptors (TRs). absence...