A5054589481- Nitric Oxide and Endothelin Effects
- Thyroid Disorders and Treatments
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Heart Rate Variability and Autonomic Control
- Anesthesia and Neurotoxicity Research
- Growth Hormone and Insulin-like Growth Factors
- Estrogen and related hormone effects
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Ion channel regulation and function
- Hormonal and reproductive studies
- Neuroscience of respiration and sleep
- Biochemical effects in animals
- Gene Regulatory Network Analysis
- Cardiovascular Effects of Exercise
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Genetics and Physical Performance
- Rabbits: Nutrition, Reproduction, Health
- Demographic Trends and Gender Preferences
- Evolutionary Psychology and Human Behavior
- Dietetics, Nutrition, and Education
- Sexual Differentiation and Disorders
- Exercise and Physiological Responses
- Regulation of Appetite and Obesity
Lomonosov Moscow State University
2015-2024
Moscow State University
2021-2024
Research & Development Institute
2024
Institute of Biomedical Problems
2017-2018
Russian Academy of Sciences
2018
State Research Center of the Russian Federation
2018
It has been suggested that the preference for low WHRs evolved because WHR provided a cue to female reproductive status and health, therefore her value. The present study aimed test whether might indeed be reliable history (with lower indicating number of children). Previous studies showed such relationship modern industrialized populations, but it not investigated in natural fertility, indigenous, more energy constrained populations facing greater trade-offs allocation than do societies....
The mechanisms of vascular alterations resulting from early thyroid hormones deficiency are poorly understood. We tested the hypothesis that antenatal/early postnatal hypothyroidism would alter activity endothelial NO pathway and Rho-kinase pathway, which specific for developing vasculature. Dams were treated with propylthiouracil (PTU, 7 ppm) in drinking water during gestation 2 weeks after delivery, their progeny had normal body weight but markedly reduced blood levels (ELISA). Small...
Introduction: Functional tests and training regimens intensity-controlled by an individual are used in sport practice, clinical rehabilitation, space medicine. The model of voluntary wheel running rats can be to explore molecular mechanisms such humans. Respiratory locomotor muscles demonstrate diverse adaptations treadmill exercise, but the effects exercise on these muscle types have not been compared yet. Therefore, this work aimed at ET rat triceps brachii diaphragm with special attention...
Abstract Membrane transporters and their functional contribution in vasculature change during early postnatal development. Here we tested the hypothesis that of Cl − channels to arterial contraction declines development this decline is associated with trophic sympathetic influence. Endothelium‐denuded saphenous arteries from 1- 2-week-old 2- 3-month-old male rats were used. Arterial was assessed isometric myograph, some experiments combined measurements membrane potential. mRNA protein...
Nitric oxide (NO) deficiency during pregnancy is a key reason for preeclampsia development. Besides its important vasomotor role, NO shown to regulate the cell transcriptome. However, role of in transcriptional regulation developing smooth muscle has never been studied before. We hypothesized that early ontogeny, arterial muscle-specific genes expression. Pregnant rats consumed NO-synthase inhibitor L-NAME (500 mg/L drinking water) from gestational day 10 till delivery, which led an increase...
Abstract Intrauterine growth restriction (IUGR) is one of the most common pathologies pregnancy. The cardiovascular consequences IUGR do not disappear in adulthood and can manifest themselves pathological alterations vasomotor control. hypothesis was tested that weakens anticontractile influence NO augments procontractile Rho-kinase arteries adult offspring. To model rat, dams were 50% food restricted starting from gestational day 11 till delivery. Mesenteric coronary male offspring studied...
Intrauterine growth retardation (IUGR) is one of the most common pathologies pregnancy. As a result this pathology, functioning many systems, including cardiovascular system, disrupted. In adult animals who have suffered IUGR, contribution procontractile mechanisms regulating vascular tone (for example, Rho-kinase signaling pathway) increases, and anticontractile endothelial NO), on contrary, decreases, which can lead to vasospasm impaired blood supply organs. Since NO pronounced vasomotor...
Aerobic physical training is used to prevent and correct many cardiovascular disorders. To study the effects of such exercise, various methods are in rodents, among which voluntary wheel running particular interest, because it close natural rat locomotion terms pattern motor activity devoid stressful influence. The aim this work was a comprehensive on nervous control heart rate (HR) rats. At age 6 weeks, animals were divided into two groups: (TR, free access wheels, n = 11) sedentary (CON,...
Nitric oxide (NO) has been shown to stimulate differentiation and increase the survival of ganglionic sympathetic neurons. The proportion neuronal NOS-immunoreactive preganglionic neurons is particularly high in newborn rats decreases with maturation. However, role NO development vascular innervation never studied before. We tested hypothesis that intrauterine deficiency weakened thereby changed contractility peripheral arteries blood pressure level two-week-old offspring. Pregnant consumed...
Antenatal/early postnatal hypothyroidism weakens NO-mediated anticontractile influence of endothelium in coronary arteries adult rats, but it remains unclear whether this occurs other vascular regions. We hypothesized that developmental thyroid deficiency is followed by region-specific changes the endothelial NO-pathway activity systemic vasculature. To explore this, we estimated effects antenatal/early on and its potential local control mechanisms rat mesenteric skeletal muscle (sural)...
Aim: Hyperthyroidism is associated with a decreased peripheral vascular resistance, which could be caused by the vasodilator genomic or non-genomic effects of thyroid hormones (TH). Non-genomic, acute, develop within several minutes and involve wide tissue-specific spectrum molecular pathways poorly studied in vasculature. We aimed to investigate mechanisms acute TH on rat skeletal muscle arteries. Methods: Sural arteries from male Wistar rats were used for isometric force recording (wire...
Aim . The deficit of thyroid function is known to be accompanied by an increase in the overall peripheral vascular resistance. This work tested hypothesis that long-term hypothyroidism leads vasoconstrictor effect Rho-kinase skeletal muscle and heart resistance arteries adult rats. Materials methods. Male Wistar rats consumed antithyroid drug propylthiouracil (PTU) drinking water (0.025%), starting at 10 weeks age. control group received PTU-free water. After 14 weeks, contractile responses...