A5091522296- Plant Gene Expression Analysis
- Photosynthetic Processes and Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Plant biochemistry and biosynthesis
- Ferroptosis and cancer prognosis
- Plant Molecular Biology Research
- Family Support in Illness
- Extracellular vesicles in disease
- T-cell and Retrovirus Studies
- Single-cell and spatial transcriptomics
- Plant nutrient uptake and metabolism
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Biochemical and biochemical processes
- Lipid metabolism and biosynthesis
- Lung Cancer Research Studies
- Glycosylation and Glycoproteins Research
- CAR-T cell therapy research
- Tryptophan and brain disorders
Zhejiang Chinese Medical University
2024
Hangzhou Hospital of Traditional Chinese Medicine
2024
The University of Texas MD Anderson Cancer Center
2018-2023
Purdue University West Lafayette
2018-2019
Background Citrulline post-translational modification of proteins is mediated by protein arginine deiminase (PADI) family members and has been associated with autoimmune diseases. The role PADI-citrullinome in immune response cancer not evaluated. We hypothesized that PADI-mediated citrullinome a source neoantigens induces response. Methods Protein expression PADI was evaluated 196 cell lines means indepth proteomic profiling. Gene assessed using messenger RNA data sets from Cancer Genome...
Activation of the NRF2 pathway through gain-of-function mutations or loss-of-function its suppressor KEAP1 is a frequent finding in lung cancer. activation has been reported to alter tumor microenvironment. Here, we demonstrated that alters tryptophan metabolism kynurenine associated with tumor-promoting, immune suppressed Specifically, proteomic profiles 47 adenocarcinoma (LUAD) cell lines (11 mutant and 36 wild-type) revealed tryptophan-kynurenine enzyme kynureninase (KYNU) as top...
Using a combination of mass-spectrometry and aptamer array-based proteomics, we characterized the protein features circulating extracellular vesicles (EVs) in context lung (LUAD) pancreatic ductal (PDAC) adenocarcinomas. We profiled EVs isolated from conditioned media LUAD PDAC cell lines to identify EV-associated cargoes released by these cancer types. Analysis resulting data identified specific pan-adenocarcinoma EV signatures. Bioinformatic analyses confirmed enrichment proteins annotated...
The Mediator complex functions as a hub for transcriptional regulation. MED5, an Arabidopsis tail subunit, is required maintaining phenylpropanoid homeostasis. A semidominant mutation (ref4-3) that causes single amino acid substitution in MED5b strong suppressor of the pathway, leading to decreased soluble accumulation, reduced lignin content and dwarfism. By contrast, loss MED5 results increased concentrations phenylpropanoids. We used reverse genetic approach identify suppressors ref4-3...
Small-cell-lung cancer (SCLC) is associated with overexpression of oncogenes including Myc family genes and YAP1 inactivation tumor suppressor genes. We performed in-depth proteomic profiling plasmas collected from 15 individuals newly diagnosed early stage SCLC before the diagnosis compared findings plasma profiles 30 matched controls to determine occurrence signatures that reflect disease pathogenesis. A total 272 proteins were elevated (area under receiver operating characteristic curve...
Abstract ATAC-seq has an emerging role in decoding mechanisms of gene regulation, offering valuable insights into pathology and treatment response disease models. However, clinical adoption methods been limited by logistical hurdles, including time-sensitive processing fresh samples compromised viability cryopreserved cells. These constraints, compounded changes open chromatin regions (OCRs) following cryopreservation, introduce unintended bias pose significant obstacles for the...
Chemoresistance represented one of the challenges in treatment advanced gastric cancer (GC). Curcumol (CUR) was found to have a certain sensitizing effect on chemoresistance, although mechanism not yet fully understood.
ABSTRACT Introduction In prostate cancer the genotype of tumour does not always predict clinical behaviour and disease aggressiveness after castration therapy. Additional factors might be important. Here we hypothesise that there is a site-specific steroid profile roadmap significance. Material methods Steroid profiles in blood plasma (BP) bone marrow aspirate (BMA) from 120 castrated patients with were evaluated mass spectrometry. We studied ligand-receptor interactions adrenal metastases...
Plant metabolic networks are precisely regulated by the spatial and temporal expression of suites genes. Among various transcription (co)factors, a multi‐protein complex, Mediator has been identified as hub for regulation. The core comprising head, middle tail domains, functions bridge between factors basal machinery, whereas CDK8 kinase module plays repressive regulatory role. It is still unclear, however, how represses target genes especially in planta . Using forward genetic screen, our...