A5091482988- Pharmacogenetics and Drug Metabolism
- Artificial Intelligence in Healthcare and Education
- Tuberculosis Research and Epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Drug Transport and Resistance Mechanisms
- Genetics and Neurodevelopmental Disorders
- Computational Drug Discovery Methods
- Neuroscience and Neuropharmacology Research
- Autism Spectrum Disorder Research
- RNA modifications and cancer
- Olfactory and Sensory Function Studies
- Biosimilars and Bioanalytical Methods
- Genetic Mapping and Diversity in Plants and Animals
- Neurogenetic and Muscular Disorders Research
- Mechanical Circulatory Support Devices
- Chromosomal and Genetic Variations
- Statistical Methods in Clinical Trials
- Alzheimer's disease research and treatments
- Cardiac Arrest and Resuscitation
- Drug-Induced Hepatotoxicity and Protection
- Biochemical Analysis and Sensing Techniques
- Innovations in Medical Education
- Neurotransmitter Receptor Influence on Behavior
- Psychological and Educational Research Studies
- Antimicrobial Resistance in Staphylococcus
Inje University
2016-2024
University of Florida
2018-2019
Columbus Oncology and Hematology Associates
2018-2019
Seoul National University
2013-2018
Korea University
2002
Korea University Medical Center
2002
Cornell University
1993
Genetic linkage maps have been constructed for the rice and maize genomes on basis of orthologous loci detected with a common set cDNA clones. Conserved groups could be identified, which together account more than two-thirds both genomes. In some instances, entire chromosomes or chromosome arms are nearly identical respect to gene order content. The results also reveal that most genes (> 72%) duplicated during ancient polyploidization still present in genome duplicate copy. comparative...
Alzheimer's disease (AD) is the most common form of dementia among elderly. Neuritic plaques whose primary component amyloid beta peptide (Aβ) and neurofibrillary tangles which are composed hyperphosphorylated tau, known to be neuropathological hallmarks AD. In addition, impaired synaptic plasticity in neuronal networks thought important mechanism underlying for cognitive deficits observed Although various causative factors, including excitotoxicity, mitochondrial dysregulation oxidative...
Abstract The neuregulin (NRG) family of epidermal growth factor-related proteins is composed a wide variety soluble and membrane-bound that exert their effects via the tyrosine kinase receptors ErbB2-ErbB4. In nervous system, functions NRG1 are essential for peripheral myelination, establishment maintenance neuromuscular sensorimotor systems plasticity cortical neuronal circuits. present study, we report an intracerebroventricular infusion attenuated cognitive impairments in 13-month-old...
Exposure to valproic acid (VPA) during pregnancy has been linked with increased incidence of autism, and repeatedly demonstrated as a useful autism mouse model. We examined the early behavioral anatomical changes well molecular in mice prenatally exposed VPA (VPA mice). In this study, we first showed that developmental delays assessed self-righting, eye opening tests impaired social recognition. addition, provide evidence primary cultured neurons from VPA-treated embryos present an increase...
Mounting evidence suggests that the etiology of autism spectrum disorders (ASDs) is profoundly influenced by exposure to environmental factors, although precise molecular and cellular links remain ill-defined. In this study, we examined how valproic acid (VPA) during pregnancy associated with an increased incidence ASD. A mouse model was established injecting VPA at embryonic day 13, its behavioral phenotypes including impaired social interaction, repetitive behaviors decreased nociception...
Astrocytes have been reported to exist in two states, the resting and reactive states. Morphological changes state of astrocytes include an increase thickness number processes, size cell body. Molecular also occur, such as expression glial fibrillary acidic protein (GFAP). However, morphological molecular during process learning memory not elucidated. In current study, we subjected Fvb/n mice contextual fear conditioning, checked for astrocytes. 1 h after type II III exhibited a unique...
BackgroundPersonalized warfarin dosing is influenced by various factors including genetic and non‐genetic factors. Multiple linear regression (LR) known as a conventional method to develop predictive models. Recently, machine learning approaches have been extensively implemented for due the hypothesis of non‐linear association between covariates stable dose.ObjectiveTo extend multiple algorithm personalized in Korean population compare with learning‐‐based algorithm.MethodFrom this cohort...
For personalized drug dosing, prediction models may be utilized to overcome the inter-individual variability. Multiple linear regression has been used as a conventional method model relationship between patient features and optimal dose. However, cannot capture non-linear relationships adversely affected by non-normal distribution collinearity of data. To this hurdle, machine learning have extensively adapted in dose prediction. In tutorial, random forest neural network will trained tandem...
WHAT IS KNOWN AND OBJECTIVE: Although patients may have received vancomycin therapy with therapeutic drug monitoring (TDM), those treated high-strength and long-term might unstable time-varying renal function. The methods used to estimate function should not be considered interchangeable pharmacokinetic (PK) modeling model-based estimation of pharmacokinetics. While Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) for has been widely integrated into clinical practice, a population...
Objectives: This study was performed to develop a population pharmacokinetic model of pyrazinamide for Korean tuberculosis (TB) patients and explore identify the influence demographic clinical factors, especially geriatric diabetes mellitus (DM), on pharmacokinetics (PK) (PZA). Methods: PZA concentrations at random post-dose points, characteristics, information were collected in multicenter prospective TB cohort from 18 hospitals Korea. Data obtained 610 divided into training test datasets...
Abstract Background Generative artificial intelligence (GAI) tools, such as large language models, have the potential to revolutionize medical research and writing, but their use also raises important ethical practical concerns. This study examines prevalence content of GAI guidelines among Korean journals assess current landscape inform future policy development. Methods Top 100 by H-index were surveyed. Author collected screened a human author AI chatbot identify GAI-related content. Key...
Large language models (LLMs) have emerged as a powerful tool for biomedical researchers, demonstrating remarkable capabilities in understanding and generating human-like text. ChatGPT with its Code Interpreter functionality, an LLM connected the ability to write execute code, streamlines data analysis workflows by enabling natural interactions. Using materials from previously published tutorial, similar analyses can be performed through conversational interactions chatbot, covering loading...
Stem cell therapy is a promising tool for the treatment of diverse conditions, including neurodegenerative diseases such as Alzheimer's disease (AD). To understand transplanted stem biology, in vivo imaging necessary. Nanomaterial has great potential and several noninvasive methods are used, magnetic resonance imaging, positron emission tomography, fluorescence (FI) near-infrared FI. However, each method limitations imaging. overcome these limitations, multimodal nanoprobes have been...
Olfactory loss is known to affect both mood and quality of life. Transient anosmia was induced in mice study the resulting changes mood, behavior, on a molecular level. by single intranasal instillation ZnSO4 BALB/c mice. Hematoxylin eosin (HE) staining, potato chip finding test were performed confirm olfactory loss. Tail suspension, forced swim, splash tests evaluate depression-related behavior; while open field, elevated plus maze used anxiety-related behavior. The mRNA levels amygdalar...
Purpose: The aims of this study was to investigate the mutual pharmacokinetic interactions between steady-state atorvastatin and metformin effect food on fixed-dose combined (FDC) tablet extended release (XR). Subjects methods: Study 1, an open-labeled, fixed sequence, multiple-dose drug-drug interaction study, divided into 2 parts. Atorvastatin (40 mg) or (1,000 XR tablets were administered once daily via mono- co-therapy for 7 days. Plasma levels 2-OH-atorvastatin, quantitatively...
Medical students are known to be subjected immense stress under competitive curricula and have a high risk of depression, burnout, anxiety sleep disorders. There is global trend switching from norm-referenced assessment (NRA) criterion-referenced (CRA), these changes may influenced the quality life (QOL), phase, quality, stress, depression medical students. We hypothesized that there significant difference QOL between CRA NRA sleep, main contributors.By administering an online survey...
Background: Olfactory loss is highly prevalent, and comorbid mood disorders are common. Considering olfactory input interconnected with the limbic system, that system manages mood, it predictable impairments in sense of smell may result changes. Methodology: Chronic deficits were induced by repeated intranasal irrigation ZnSO4 for 12 weeks BALB/c mice. H&E staining, OMP potato chip finding test performed to confirm loss. Tail suspension, forced swim, splash tests evaluate depression, as...
Dehydroevodiamine·HCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on behavioral abnormality caused by stress. demonstrated that can improve stress-induced impairments depression-like behaviors using open-field test, Y-maze test forced swimming test. treatment significantly recovered decreases levels neural adhesion molecule (NCAM) proteins stress viability. Our results suggested is...
The optimal diagnosis and treatment of tuberculosis (TB) are challenging due to underdiagnosis inadequate monitoring. Lipid-related genes crucial components the host immune response in TB. However, their dynamic expression potential usefulness for monitoring anti-TB unclear.