Background: SARS-CoV-2 is an RNA virus that undergoes mutation producing a variety of strains. Mutagens include UV radiation, metals, and endogenous components organisms. Each strain specific in terms virulence, immune response the body efficacy vaccines. 
 Conclusion: Researchers need to gather data collaborate with global organizations learn about newly evolving Information mutations variants are inevitable understanding transmission developing vaccines end COVID-19 pandemic.

Breast cancer is the second most common in world and by far frequent among women.The present study was undertaken to assess awareness of breast warning signs screening methods women Pokhara valley, Nepal.A cross-sectional questionnaire survey carried out a community setting with female population. The administered face-to-face interviews trained research assistants.Nepalese demonstrated poor like lump, lump under armpit, bleeding or discharge from nipple, pulling changes position nipple...

No abstract available.

Background: The novel coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus emerged as a global pandemic in December 2019, leading to significant health concerns. As progressed, post-recovery manifestations survivors became growing issue. Therefore, this comparative study aimed assess post-COVID complication difference between infection and reinfection patients. Methods: This cross-sectional was conducted department of project research, Dhaka Community Medical College Hospital,...

Currently a large number of atypical antipsychotics available in the market are endorsed as better option for treating schizophrenia than typical antipsychotics. Information regarding utilization pattern antipsychotic drugs is lacking Nepalese population particularly Western Nepal. By means this study one expected to acquire an idea concerning clinician’s preference actual clinical setup. The main objective was find commonest prescribed tertiary care center among hospitalized patients This...

No abstract available.

Background Accreditation of curriculum by students may be useful in further modification teaching and learning methods medical colleges any country specially Nepal. Course sciences is made learned professors Universities, politicians the government officers without consulting for whom it made. In Nepal, Medical education an experimental integrated four half years MBBS degree. Until now has not been assessed as to what type Doctors we are producing. This paper aims on objective find out...

Introduction: In developing countries like Nepal medicines can be acquired from the chemist's without of a prescription which sometime may have many drawbacks due to intake excessive drugs proper diagnosis. The primary objective study was find out pattern self-medication practice among preclinical medical students at Manipal College Medical Sciences.Materials and Methods: This cross sectional carried using structured questionnaire Sciences, Pokhara, between November 2012- July 2014.Results:...

Background Blood group, Bleeding Time and Clotting time are clinically useful tests, extensively used during blood transfusion, platelet disorders a variety of forms treatment in hospitals. The objective our study was to assess the country wise distribution groups compare bleeding clotting with respect group. Material Methods This Observational Study has been performed at Manipal College Medical Sciences, period 1st May 2010 31st August–2011. carried out on undergraduate medical students...

Background Anxiety is the most widespread psychiatric disorder and generalized anxiety common disease seen in primary care setting. Currently there are a number of anxiolytic drugs commercially available market for treatment these disorders such as Benzodiazepines like Diazepam, Chlordiazepoxide, Alprazolam, Betablockers Propranolol H1 Antihistaminics Hydroxyzine. Some newer anxiolytics Buspirone Azapirone group marketed better drug than traditional drugs. promoted anxiety, it does not cause...

Background: According to WHO, it is estimated that major depression would be the second most leading cause of disability in world by 2020. Drug utilization study defined as marketing, distribution, prescription and use drugs a society highlighting on resulting medical, social economic consequences. The main objective this was find pattern antidepressants prescribed tertiary care centre with hospitalized patients Western Nepal.Methods: A hospital based observational done between 1st October...

Background Career choice of medical students plays a vital role for health care system country. It also crucial to bring specialties into mainstream focus. Materials and Method A cross-sectional, questionnaire-based study has been performed at Manipal College Medical Sciences, during the period 1st May 31st August–2011. self reported questionnaire was given undergraduate Basic sciences. Questionnaire included career choices, nature career, reason choice, education level occupation in their...

Chandipura virus (CHPV) is currently implicated in outbreaks of viral encephalitis rural India. The current outbreak India has grown to 59 cases, 51 which have been reported from Gujarat and the remaining Rajasthan. It utmost importance that all relevant health authorities carefully monitor ongoing situation bolster protect international security ensure it not compromised. causes febrile disease. After phase, patients begin present with neurological symptoms, as neurotropic nature results...

An innovative web-based system was developed to allow patient-reported outcome measures (PROMs) be easily administered. Stakeholders guided the design and implementation. The software gives patients access their current previous scores. This pilot study focused on undergoing arthroscopic subacromial decompression, evaluated using Oxford shoulder score (OSS). Patients showing good improvement in OSS were offered choice return for routine follow-up clinic appointments, or continue...

No abstract available.

Human IgG specific for beta-endorphin was identified by enzyme-linked immunoabsorbent assay and isolated affinity chromatography. From a sample of 27 subjects, three individuals with major depression demonstrated plasma highly reactive human beta-endorphin, while four other subjects (two two randomly selected blood donors) had intermediate reactivity. The recognition site retained F(ab')2 fragments.

It is mandatory to calculate sample size in any type of research medical science get a generalized conclusion for the population under study. If study well designed with desired then standard error will be less and power precision good. All statistical procedures become valid this context.