A5051773155- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Mechanisms of cancer metastasis
- Vaccine Coverage and Hesitancy
- MXene and MAX Phase Materials
- Diabetes Treatment and Management
- Diabetes Management and Research
- Cancer therapeutics and mechanisms
- Cell death mechanisms and regulation
- Pharmaceutical and Antibiotic Environmental Impacts
- Epilepsy research and treatment
- Cancer Cells and Metastasis
- SARS-CoV-2 detection and testing
- NF-κB Signaling Pathways
- COVID-19 diagnosis using AI
- Click Chemistry and Applications
- Telomeres, Telomerase, and Senescence
- COVID-19 epidemiological studies
- Synthesis and bioactivity of alkaloids
Monash University Malaysia
2020-2025
Mahsa University
2019
Monash University
2013-2014
International Medical University
2012
Abstract Inappropriate use of antibiotics has been shown to contribute the occurrence multidrug-resistant organisms (MROs). A surveillance study was performed in largest tertiary care hospital Kuala Lumpur, Malaysia, from 2018 2020 observe trends broad-spectrum (beta-lactam/beta-lactamases inhibitors (BL/BLI), extended-spectrum cephalosporins (ESC), and fluoroquinolones (FQ)) against MRO (carbapenems, polymyxins, glycopeptides) usage correlation between antibiotic consumption MROs. The...
Abstract Cannabis–drug interactions have caused significant concerns, mainly due to their role in the cytochrome P450 (CYP) enzyme‐mediated metabolic pathway of numerous medications. A systematic review was conducted gain an overview potential cannabis with different drug classes by extracting pertinent information from published study data. From inception October 1, 2023, we performed a search PubMed, Scopus, clinicaltrials.gov , and Web Science. We included 54 out 464 articles, total 20...
Abstract Purpose Gene therapy is a promising and novel therapeutic strategy for many mutated gene-associated diseases, including breast cancer. However, it poses significant biological drawbacks such as rapid clearance from the circulatory system low cellular uptake of exogenously delivered functional nucleic acids. The development efficient biocompatible carriers genetic materials has been extensively explored in literature, functionalization nanoparticles (NPs) with cancer cell-recognizing...
Abstract Despite the high efficacy and safety demonstrated in clinical trials, COVID-19 booster vaccination rates Malaysia remain below 50% among general public. This study explores factors influencing public acceptance of vaccine Malaysian population. The questionnaire included variables on sociodemographics, knowledge, Health Belief Model (HBM) constructs. Based Chi-squared test contingencies, a t-test multivariate logistic regression analysis 411 collected responses, findings revealed...
Genetic intervention via the delivery of functional genes such as plasmid DNA (pDNA) and short-interfering RNA (siRNA) offers a great way to treat many single or multiple genetic defects effectively, including mammary carcinoma. Delivery naked therapeutic siRNAs is, however, short-lived due biological clearance by scavenging nucleases circulating monocytes. Low cellular internalization negatively-charged nucleic acids further causes low transfection silencing activity. Development safe...
Inorganic nanoparticles hold great potential in the area of precision medicine, particularly for treating cancer owing to their unique physicochemical properties, biocompatibility and improved pharmacokinetics properties compared organic counterparts. Here we introduce strontium sulfite as new pH-responsive inorganic nanocarriers efficient transport siRNAs into breast cells. We employed simplest nanoprecipitation method generate (SSNs) demonstrated dramatic roles NaCl d-glucose particle...
RNA interference (RNAi) is a powerful approach in functional genomics to selectively silence messenger mRNA (mRNA) expression and can be employed rapidly develop potential novel drugs against complex disease like cancer. However, naked siRNA being anionic unable cross the cell membrane through passive diffusion therefore, delivery of remains major hurdle overcome before technology fully exploited pH-sensitive carbonate apatite has recently been developed as an efficient tool deliver into...
Cervical cancer is the second most common and fourth leading cause of cancer-related deaths among women. Advanced stage disease treated with radiation therapy chemotherapy poor therapeutic outcome adverse side effects. NFκB, a well-known transcription factor in control immunity inflammation, has recently emerged as key regulator cell survival through induction antiapoptotic genes. Many human cancers, including cervical carcinoma, constitutively express NF-κB blockade expression its subunit...
Event Abstract Back to Development of novel inorganic strontium nanoparticles for delivery pDNA and siRNA breast cancer cell ATHIRAH BAKHTIAR1*, Md Ezharul H. Chowdhury2, Iekhsan Othman3 Anuar Zaini3 1 Faculty Pharmacy, Mahsa University, Malaysia 2 Monash University Malaysia, 3 Australia Background Recent studies have been focused on developing smart efficient transgenes siRNAs into cancerous cells an animal model through active passive targeting. Precipitation reaction is one the facile...