A5077492704- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Diet and metabolism studies
- Microbial Community Ecology and Physiology
- Polar Research and Ecology
- Vibrio bacteria research studies
- Genomics and Phylogenetic Studies
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Nutritional Studies and Diet
- Antibiotics Pharmacokinetics and Efficacy
- Diabetes Treatment and Management
- Protist diversity and phylogeny
- Urinary Tract Infections Management
- Bacteriophages and microbial interactions
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Probiotics and Fermented Foods
- Food Security and Health in Diverse Populations
- Clostridium difficile and Clostridium perfringens research
- Salmonella and Campylobacter epidemiology
- Medication Adherence and Compliance
- Tryptophan and brain disorders
- Phytase and its Applications
- Animal Nutrition and Physiology
Monash University Malaysia
2019-2025
International Medical University
2015-2024
University of Southampton
2024
International Islamic University Malaysia
2024
University of Birmingham
2024
Singapore Science Park
2022
University of Malaya
2009-2020
Toronto Western Hospital
2020
Ankara Spine Center
2020
The University of Melbourne
2020
Chicken gut microbiota has paramount roles in host performance, health and immunity. Understanding the topological difference microbial community composition is crucial to provide knowledge on functions of each members physiological maintenance host. The profiling chicken was commonly performed previously using culture-dependent early culture-independent methods which had limited coverage accuracy. Advances technology based next-generation sequencing (NGS), offers unparalleled depth...
To determine whether probiotics are effective for constipation, a common and often difficult-to-treat problem, in Parkinson disease (PD).
Gut microbiome alterations in Parkinson disease (PD) have been reported repeatedly, but their functional relevance remains unclear. Fecal metabolomics, which provide a readout of microbial activity, scarcely investigated. We investigated fecal and metabolome PD, clinical relevance.Two hundred subjects (104 patients, 96 controls) underwent extensive phenotyping. Stool samples were analyzed using 16S rRNA gene sequencing. metabolomics performed two platforms, nuclear magnetic resonance (NMR)...
Abstract No studies have investigated the influence of ethnicity in a multi-ethnic middle-income country with long-standing history co-habitation. Stool samples from 214 Malaysian community members (46 Malay, 65 Chinese, 49 Indian, and 54 Jakun) were collected. The gut microbiota participants was using 16S amplicon sequencing. Ethnicity exhibited largest effect size across (PERMANOVA Pseudo-F = 4.24, R 2 0.06, p 0.001). Notably, on retained even after controlling for all demographic, dietary...
The gut-brain axis is a hot topic in Parkinson's disease (PD). It has been postulated that gut pathogens and dysbiosis can contribute to peripheral inflammatory states or trigger downstream metabolic effects exacerbate the neurodegenerative process PD. Several preclinical clinical studies have demonstrated disrupted intestinal permeability, inflammation, altered microbiome, reduced fecal short-chain fatty acids In this regard, microbial-directed therapies such as probiotics are emerging...
Abstract Gut microbiota plays an important role in mammalian host metabolism and physiological functions. The functions are particularly young children where rapid mental physical developments taking place. Nevertheless, little is known about the gut microbiome factors that contribute to microbial variation of South East Asian children. Here, we compared bacterial richness composition pre-adolescence Northern Malaysia. Our subjects covered three distinct ethnic groups with relatively narrow...
Abstract Microbial dysbiosis has been implicated in the pathogenesis of oral cancer. We analyzed compositional and metabolic profile bacteriome three specific niches cancer patients along with controls using 16SrRNA sequencing (Illumina Miseq) DADA2 software. found major differences between control subjects. Bacterial communities associated tumor surface deep paired tissue differed significantly. Tumor surfaces carried elevated abundances taxa belonging to genera Porphyromonas,...
Abstract Inappropriate use of antibiotics has been shown to contribute the occurrence multidrug-resistant organisms (MROs). A surveillance study was performed in largest tertiary care hospital Kuala Lumpur, Malaysia, from 2018 2020 observe trends broad-spectrum (beta-lactam/beta-lactamases inhibitors (BL/BLI), extended-spectrum cephalosporins (ESC), and fluoroquinolones (FQ)) against MRO (carbapenems, polymyxins, glycopeptides) usage correlation between antibiotic consumption MROs. The...
Phages, which are often used therapeutically, have begun to receive interest as alternatives antibiotic growth promoters (AGPs) for enhancing chicken growth. Another option that has been extensively studied a promoter in chickens is probiotics. To the best of our knowledge, there currently no study available on use phages and probiotics combination potential feed additives broiler chickens. Therefore, this demonstrated effects phage cocktail, probiotics, their performance gut microbiota A...
Carbapenem resistant Enterobacteriaceae is a growing concern worldwide including Malaysia. The emergence of this pathogen worrying because carbapenem one the 'last-line' antibiotics. main objective study was to determine prevalence genetic mechanisms and clinical risk factors Klebsiella pneumoniae (K. pneumoniae) in In study, seventeen K. strains isolated from tertiary teaching hospital 2013 were studied. Minimal inhibitory concentration (MIC) bacterial determined genes associated with...
Objective: While some oral carcinomas appear to arise de novo, others develop within long-standing conditions of the cavity that have malignant potential, now known as potentially disorders (OPMDs). The bacteriome associated with OPMD has been studied a lesser extent than cancer. To characterize association in detail we compared whole mouth fluid (WMF) patients leukoplakia, cancer and healthy controls.Methods: WMF from 20 leukoplakia patients, 31 23 controls were profiled using Illumina...
Diabetes is one of the leading causes chronic kidney disease (CKD) and end-stage renal disease. This study aims to develop validate different risk predictive models for incident CKD progression in people with type 2 diabetes (T2D).We reviewed a cohort T2D seeking care from two tertiary hospitals metropolitan cities state Selangor Negeri Sembilan January 2012 May 2021. To identify 3-year predictor developing (primary outcome) (secondary outcome), dataset was randomly split into training test...