A5032346414- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Epilepsy research and treatment
- Pharmaceutical studies and practices
- Archaeological and Historical Studies
- HIV/AIDS drug development and treatment
- Historical Studies of Medieval Iberia
- Medieval Architecture and Archaeology
- Historical and socio-economic studies of Spain and related regions
- Drug Transport and Resistance Mechanisms
- Urbanism, Landscape, and Tourism Studies
- Analytical Methods in Pharmaceuticals
- Neutropenia and Cancer Infections
- Pharmacogenetics and Drug Metabolism
- Hematopoietic Stem Cell Transplantation
- Metabolism and Genetic Disorders
- HIV Research and Treatment
- Mediterranean and Iberian flora and fauna
- Pneumocystis jirovecii pneumonia detection and treatment
- Lipoproteins and Cardiovascular Health
- Antibiotic Use and Resistance
- Urinary Bladder and Prostate Research
- Cardiac, Anesthesia and Surgical Outcomes
- Mycobacterium research and diagnosis
- Anesthesia and Pain Management
Universidad de Salamanca
2009-2024
Pontificia Universidad Católica de Chile
2014-2024
Janssen (Belgium)
2024
Universidad de Las Palmas de Gran Canaria
2024
Merck Serono (Switzerland)
2024
Universidad de Granada
2007-2024
Instituto de Investigación Biosanitaria de Granada
2024
Roche (Switzerland)
2024
Novartis (Switzerland)
2024
Institut Català de la Salut
2022
PCR-restriction enzyme pattern analysis of a 439 bp hsp65 gene segment identified 113 unique isolates among non-pigmented rapidly growing mycobacteria (RGM) from clinical and environmental sources that failed to match currently recognized species patterns. This group represented 40% recovered bronchoscope contamination pseudo-outbreaks, 0% disease-associated nosocomial outbreaks 4% routine the Mycobacterium abscessus/Mycobacterium chelonae submitted Mycobacteria/Nocardia laboratory for...
This review summarizes the pharmacokinetic properties of HMG-CoA reductase inhibitors (or statins) reported in animals. Lovastatin and simvastatin are administered as lactone prodrugs contrast to other statins, which generally formulated pharmacological active hydroxy acid form. Pharmacokinetics vary with statin animal species considered. Oral absorption is rapid bioavailability low due an extensive first-pass metabolism. Pitavastatin exception, high all except monkeys (80% vs. 18%). Plasma...
This study determines vancomycin (VAN) population pharmacokinetics (PK) in adult patients with hematological malignancies. VAN serum concentration data (n = 1,004) from therapeutic drug monitoring were collected retrospectively 215 patients. A one-compartment PK model was selected. parameters generated using the NONMEM program. graphic approach and stepwise generalized additive modeling used to elucidate preliminary relationships between clinical covariates analyzed. Covariate selection...
ABSTRACT A population pharmacokinetic model for efavirenz has been developed from therapeutic drug monitoring data in human immunodeficiency virus (HIV)-positive patients by using a nonlinear mixed-effect model. The plasma concentrations ( n = 375) of 131 were analyzed high-performance liquid chromatography with UV detection. Pharmacokinetic parameters estimated according to one-compartment effects sex, age, total body weight, height, mass index, and HIV treatment analyzed. In subgroup 32...
This research aims to distinguish genetic sedimentary processes building canyon geomorphological patterns and the factors driving different activities in two nearby Mediterranean shelf-incised submarine canyons (Carchuna Motril) that exhibit degrees of incision on narrow margin northern Alboran Sea. The straight Carchuna Canyon incises shelf up 200 m off coastline steep walls featuring terraces, muddy sands with high contents organic matter along thalweg, transported benthic foraminifera...
Experiments were carried out to clarify the sites of action beta-adrenergic agonists in skeletal muscle microsomes. Microsomes fractionated into longitudinal reticulum, terminal cisternae, and isolated transverse tubules. Transverse tubules selectively labeled tracked with [3H]ouabain. receptor was identified by [3H]dihydroalprenolol binding. Assays receptor, adenylate cyclase, protein kinase-stimulated phosphorylation showed: 1) detected a density 0.61 pmol/mg protein. No significant...
Summary This prospective observational study aimed to assess the feasibility and efficacy of bilateral continuous paravertebral blockade combined with general anaesthesia in ‘on‐pump’ cardiac surgery. One hundred eleven elective patients had two catheters inserted: one either side midline within 2.5 cm spinous process third or fourth thoracic vertebrae, through which a mixture ropivacaine fentanyl was infused during after In first 47 patients, haemodynamic analgesia data were recorded. all...
Despite extensive clinical experience with efavirenz (EFV), unpredictable interindividual variabilities in efficacy and toxicity remain important limitations associated the use of this antiretroviral. The purpose study was to determine factors affecting EFV pharmacokinetics develop a pharmacokinetic/pharmacogenetic (PK/PG) model Caucasian population HIV-infected patients. In total, 869 plasma concentrations from 128 patients treated were quantitatively assessed using validated...
A population analysis of the kinetics valproic acid (VPA) in children with epilepsy was performed order to characterize covariates which influence VPA clearance (CL).A total 770 steady-state serum concentration samples analysed. These were collected during therapy from 255 children, aged 0.1-14 years and weighting 4-74 kg. Age, body weight (TBW), daily dose, sex comedication carbamazepine (CBZ) considered as covariates. Population made NONMEM program, assuming a one-compartment model, fixing...
This study develops a population pharmacokinetic model for lamotrigine (LTG) in Spanish and German patients diagnosed with epilepsy. LTG steady-state plasma concentration data from therapeutic drug monitoring were collected retrospectively 600 patients, total of 1699 concentrations. The analyzed according to one-compartment using the nonlinear mixed effect modelling program. influences origin (Germany or Spain), sex, age, body weight, comedication valproic acid (VPA), levetiracetam,...
Aims The aims of the study were: (i) to characterize pharmacokinetics (PK) doxorubicin (DOX) and doxorubicinol (DOXol) in patients diagnosed with non‐Hodgkin's lymphoma (NHL) using a population approach; (ii) evaluate influence various covariates on PK DOX; (iii) role DOX DOXol exposure haematological toxicity. Methods Population modelling (using NONMEM) was performed plasma concentration–time data from 45 NHL treated R‐CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine prednisone)....
The aim of the present study was to estimate valproic acid (VPA) clearance values for adult patients with epilepsy, using serum concentrations gathered during their routine clinical care. Retrospective steady state data (n=534) collected from 208 receiving VPA were studied. Data analysed according a one-compartment model NONMEM program. influence daily dose (Dose), gender, age, total body weight (TBW), and comedication carbamazepine (CBZ), phenytoin (PHT) phenobarbital (PB) investigated....
Background: A relationship between plasma concentrations and viral suppression in patients receiving lopinavir (LPV)/ritonavir (RTV) has been observed. Therefore, it is important to increase our knowledge about factors that determine interpatient variability LPV pharmacokinetics (PK). Methods: The study, designed develop validate population PK models for RTV, involved 263 ambulatory treated with 400/100 mg of LPV/RTV twice daily. database 1110 RTV (647 from a single time-point 463 73 full...
(1) Background: The aim of this study was to explore the valproic acid (VPA) pharmacokinetic characteristics in a large population pediatric and adult Caucasian patients establish robust (PopPK) model. (2) Methods: A total 2527 serum VPA samples collected from 1204 included therapeutic drug monitoring program were retrospectively analyzed. Patients randomly assigned either model development group or an external evaluation group. PopPK analysis performed on 1751 776 with NONMEM using...
Abstract Sporadic colorectal cancer (sCRC) is the third most frequent worldwide and second common cause of cancer-related deaths (mainly due metastatic dissemination). We investigated immunohistochemical expression frequently altered proteins in primary tumors from 51 patients (25 liver 26 non-metastatic cases) with a median 103 months follow-up (103 months). evaluated EGFR copy number (using SNP arrays FISH) its regulation (by mRNA miRNA arrays). found differences between sCRCs for MLH1 ( p...
In this report, we describe seven new patients with a severe deficiency of glutaryl-CoA dehydrogenase in cultured skin fibroblasts. Three the studied excreted high levels glutaric acid. The remaining four presented lack significant aciduria. However, acid was found increased CSE both groups patients, urine were not related to their metabolic condition at time sampling. Hypocarnitinemia common finding. Some also showed defects on respiratory chain complexes muscle biopsy. Only one patient has...
The aim of the authors' study was to investigate factors affecting carbamazepine (CBZ) clearance (CL) in children with epilepsy. evaluated were total body weight (TBW), age, dose, sex, and phenobarbital (PB) valproic acid (VA) comedication. A 387 steady-state serum concentration samples analyzed. These collected during CBZ therapy from 201 children, aged 1-14 years weighting 9-78 kg. Population CL calculated by using NONMEM, a one-compartment model first-order absorption elimination. rate,...