A5062107883- T-cell and B-cell Immunology
- Milk Quality and Mastitis in Dairy Cows
- Aquaculture disease management and microbiota
- Animal Genetics and Reproduction
- Cultural Heritage Materials Analysis
- Mycobacterium research and diagnosis
- Animal Virus Infections Studies
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Xenotransplantation and immune response
- Maritime and Coastal Archaeology
- Medicinal Plant Pharmacodynamics Research
National Bureau of Animal Genetic Resources
2019-2023
The major histocompatibility complex (MHC) is an organized cluster of tightly linked genes, present in all vertebrates, playing important role the immune system, except jawless fish [1]. MHC was first identified during tissue transplantation studies mice [2] and known for its histocompatibility. Consequently, discovered regulation [3] several other functions [4,5]. function to code specialized antigen-presenting receptor glycoproteins, also called as molecules. products these genes are...
Bovine lymphocyte antigen (BoLA) DRB3 locus in healthy and mastitis affected cattle has been genotyped by a polymerase chain reaction restriction fragment length polymorphisms (PCR-RLFP) using RsaI enzyme, followed sequencing. In 130 farm animals, 25 BoLA alleles have detected PCR-RFLP. Three distinct allelic patterns significantly associated with Karan Fries crossbred Sahiwal indicus identified, whereas, four other were high frequency among animals. Sequencing of RFLP genotypes revealed 47...
Among different cattle types, Bos indicus are known for their ability to better resist the tropical microbial infections comparatively, wherein MHC molecules play a significant role. In this study allelic diversity at locus, DQA of indicus, taurus and crossbred taurine-indicus has been explored understand possible role region in differential immune response. Thirty nine alleles were identified, out which 14 novel, along with documentation duplication alleles. Indicus population presented...
n the current study, genetic diversity analysis of MHC class II (DRB3) locus has been documented among indicus cattle breeds. Genotyping 192 zebu belonging to eight different breeds, was carried out identify allelic patterns by PCR-RFLP BoLA DRB3 exon 2, revealing 43different restriction patterns. Highest BoLA-DRB3 gene observed in Malnad Gidda and Gir least Mewati, Tharparkar Sahiwal cattle. Allelic pattern, BM most frequently heterozygous pattern withhighest frequency Mewati Ladakhi Few...
Expression analysis of immune response genes in the mammary gland tissues both healthy and infected animals help to explain genetic basis differential response. This study was conducted analyze expression MHC class II DRB3 gene, mastitis-affected indicus (Sahiwal) crossbred (Karan Fries) cattle. Real-time PCR performed on cDNA synthesized from RNA isolated PBMCs mastitis animals. However, no significant difference observed two populations. The results point towards polymorphism supposed be...