A5066680658- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Folate and B Vitamins Research
- Cerebrovascular and Carotid Artery Diseases
- Chronic Kidney Disease and Diabetes
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Renal function and acid-base balance
- Diabetes Treatment and Management
- TGF-β signaling in diseases
- Bipolar Disorder and Treatment
- Genetic Syndromes and Imprinting
- Potassium and Related Disorders
- Tryptophan and brain disorders
- Heterotopic Ossification and Related Conditions
- Apelin-related biomedical research
- Bone health and treatments
- Eating Disorders and Behaviors
- Cardiac pacing and defibrillation studies
- Renal and Vascular Pathologies
Copenhagen University Hospital
2021-2025
Rigshospitalet
2021-2025
University of Copenhagen
2021-2025
Gentofte Hospital
2023
Cardiovascular disease is the leading cause of mortality in patients with chronic kidney (CKD). APOM plays a critical role reverse cholesterol transport by facilitating formation pre-β-HDL (high-density lipoprotein) and enabling binding S1P (sphingosine-1-phosphate) to HDL, complex involved several antiatherogenic processes. In this study, we sought investigate potential association between plasma levels risk adverse cardiovascular outcomes individuals CKD. Plasma were quantified using...
Abstract Background Myocardial work is a novel echocardiographic measure that offers detailed insights into cardiac mechanics. We sought to characterize function by myocardial in patients with chronic kidney disease (CKD). Methods prospectively enrolled 757 non-dialysis-dependent CKD and 174 age- sex-matched controls. Echocardiographic pressure-strain loop analysis was performed acquire the global index (GWI). Linear regressions were investigate association between estimated glomerular...
Plasma (p-)activin A is elevated in chronic kidney disease-mineral and bone disorder (CKD-MBD). Activin inhibition ameliorates CKD-MBD complications (vascular calcification disease) rodent CKD models. We examined whether p-activin was associated with major adverse cardiovascular events (MACE), all-cause mortality patients.The study included 916 participants (741 patients 175 controls) from the prospective Copenhagen cohort. Comparisons of estimated glomerular filtration rate (eGFR), coronary...
Background Chronic kidney disease accelerates both atherosclerosis and arterial calcification. The aim of the present study was to explore whether maximal carotid plaque thickness (cPTmax) increased in patients with chronic compared controls associated cardiovascular severity calcification coronary arteries. Methods group consisted 200 stage 3 from Copenhagen Kidney Disease Cohort 121 age- sex-matched controls. cPTmax assessed by ultrasound computed tomography scanning. Results Carotid...
Myocardial work is a novel measure of potential value for diagnosing coronary artery disease (CAD). It may therefore be useful in patients with chronic kidney (CKD), whom the diagnostic work-up can challenging.
ObjectiveEchocardiographic findings in chronic kidney disease (CKD) vary. We sought to estimate the prevalence of abnormal cardiac structure and function patients with CKD their association estimated glomerular filtration rate (eGFR) urine albumin/creatinine ratio (UACR).MethodsWe prospectively enrolled 825 outpatients non-dialysis-dependent CKD, mean age 58± 13 yrs, 175 matched healthy controls, 60±12 yrs. Echocardiography included assessment left ventricular (LV) hypertrophy, LV ejection...
ABSTRACT Background Vascular calcification is a known risk factor for cardiovascular events and mortality in patients with chronic kidney disease (CKD). However, since there lack of studies examining several arterial regions at time, we aimed to evaluate the major adverse (MACE) all-cause according calcium scores five sites. Methods This was prospective study 580 from Copenhagen CKD Cohort. Multidetector computed tomography coronary carotid arteries, thoracic aorta, abdominal aorta iliac...
Abstract Purpose We investigated the associations between cardiac parameters and aetiologies of CKD in an exploratory study. Methods The study population consisted 883 participants, 174 controls 709 patients with including diabetic nephropathy/renovascular KD diabetes mellitus, hypertensive/renovascular nephropathy, tubulointerstitial nephritis, glomerulonephritis/vasculitis, polycystic (PKD), unknown origin. Echocardiographic measures included left ventricular (LV) ejection fraction, global...
Classical risk scoring systems underestimate the of cardiovascular disease in chronic kidney (CKD). Coronary artery calcium score (CACS) has improved prediction events patients with CKD. The maximal carotid plaque thickness (cPTmax) measured ultrasound scans arteries demonstrated similar predictive value as CACS general population. This is first study to investigate whether cPTmax can predict CKD and compare
Abstract Background and Aims Classical risk scoring systems highly underestimate the elevated of cardiovascular (CV) disease in chronic kidney (CKD) (1). Coronary artery calcification score (CACS) has improved prediction CV events patients with CKD (2). Recently, ultrasound examination carotid arteries measurement maximal plaque thickness (cPTmax) demonstrated similar predictive value as CACS general population (3). This is first study to investigate whether cPTmax can predict CKD. We also...
Abstract Background Left ventricular diastolic dysfunction is frequent in chronic kidney disease (CKD) and suspected to be linked a worse renal prognosis. Purpose To investigate the association between ratio of early mitral inflow velocity tissue (E/e') measured by Doppler echocardiography development end-stage patients with non-dialysis-dependent CKD. Methods This prospective cohort study included individuals CKD previous nephrology-related hospital contact. All participants underwent...
Abstract Background Heart failure (HF) is a frequent comorbidity among patients with chronic kidney disease (CKD). Echocardiography allows for simple, non-invasive evaluation of structural and functional heart that could potentially classify at high risk HF. Purpose This study aimed to assess the prevalence HF stages A-D defined by AHA/ACC/HFSA in CKD patients, report incidence rates renal outcomes mortality these stages. Methods prospective cohort study. Patients aged 30 75 years estimated...
Abstract Background The ratio of early diastolic inflow to strain rate, E/e'sr, is a novel echocardiographic measure, which has been shown correlate better with left ventricular (LV) filling pressures than the conventionally used E/e' (1). Additionally, E/e'sr demonstrated prognostic value in various patient populations (2). Patients chronic kidney disease (CKD) suffer frequently dysfunction and elevated (3). We wanted investigate, how associates two central measures function: estimated...
Abstract Background and Aims Chronic kidney disease (CKD) accelerates both atherosclerosis arterial calcification. The aim of the present study was to explore whether maximal carotid plaque thickness (cPT max) increased in patients with CKD stage 3 compared controls associated cardiovascular severity calcification coronary arteries. Method group consisted 200 from Copenhagen Cohort 121 age- sex-matched controls. cPT max assessed by ultrasound computed tomography scanning. Results Carotid...
Abstract Background and Aims The relation between chronic kidney disease adverse cardiovascular events is well-established. It also known that traditional risk factors of such as smoking, low-density lipoprotein (LDL) cholesterol increased blood pressure, cannot fully explain the burden observed in patients with disease. In addition, do not demonstrate typical clinical symptoms Thus, good biomarkers for identifying at a better understanding pathophysiology leading to are needed. objective...
Background: Cardiovascular disease is the leading cause of mortality amongst patients with chronic kidney (CKD). This first study using 3-dimensional echocardiography (3DE) to investigate associations between adverse changes left ventricle, and different stages CKD. Methods: Participants were recruited from Copenhagen CKD cohort Herlev-Gentofte study. Patients stratified according GFR category (G1+2: eGFR≥60mL/min/1.73m 2 , G3: eGFR = 30-59mL/min/1.73m G4+5: eGFR≤29mL/min/1.73m ),...