A5005564051- HIV/AIDS drug development and treatment
- Biochemical and Molecular Research
- Analytical Chemistry and Chromatography
- Atherosclerosis and Cardiovascular Diseases
- Analytical Methods in Pharmaceuticals
- Ethnobotanical and Medicinal Plants Studies
- Erythropoietin and Anemia Treatment
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Phytochemistry and Biological Activities
- Lipid metabolism and disorders
- Antioxidant Activity and Oxidative Stress
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Fibrosis and Remodeling
- Platelet Disorders and Treatments
- Pharmaceutical Quality and Counterfeiting
- Angiogenesis and VEGF in Cancer
- Computational Drug Discovery Methods
- Cardiovascular Health and Risk Factors
- Sulfur Compounds in Biology
- Dye analysis and toxicity
- Identification and Quantification in Food
- Plant Toxicity and Pharmacological Properties
- Hemoglobinopathies and Related Disorders
Accra Technical University
2014-2024
Hull York Medical School
2014-2021
University of Hull
2014-2021
Western University
2017-2018
University of Bradford
2008
Hartford Hospital
2007
Children's National
2007
Background: Maintenance of the ratio glutathione in reduced (GSH) and oxidised (GSSG) state cells is important redox control, signal transduction gene regulation, factors that are altered many diseases. The accurate reliable determination GSH GSSG simultaneously a useful tool for oxidative stress determination. Measurement limited primarily to underestimation overestimation as result auto-oxidation GSH. aim this study was overcome limitation develop, optimise validate reverse-phase high...
In this study, we examined the role of MALAT1, a highly conserved nuclear long non-coding RNA molecule, in chronic diabetic complications affecting heart and kidneys using both vitro vivo models: human endothelial cell culture Malat1 knockout mice model.Findings from our experiments demonstrated that MALAT1 was predominantly localized to speckles cells expression significantly increased following incubation with high glucose association inflammatory cytokines. As for experiments, used...
This study, conducted as part of our overall goal regular pharmacovigilance antimalarial medicines, reports on the quality 132 artemisinin-based medicines distributed in Ghana and Togo. Three methods were employed evaluation—basic (colorimetric) tests for establishing identity requisite active pharmaceutical ingredients (APIs), semi-quantitative TLC assay identification estimation API content, HPLC a more accurate quantification content. From basic tests, only one sample totally lacked API....
Quercetin is reported to reduce blood pressure in hypertensive but not normotensive humans, the role of endothelial redox signaling this phenomenon has been assessed. This study investigated effects physiologically obtainable quercetin concentrations a human primary cell model dysfunction order elucidate mechanism action its antihypertensive effects.Angiotensin II (100 nM, 8 h) induced dysfunction, characterized by suppressed nitric oxide availability (85 ± 4% p<0.05) and increased...
Concerns exist regarding the pro-oxidant and inflammatory potential of intravenous (IV) iron due to labile plasma (LPI) generation. This IRON-CKD trial compared effects different IV irons on oxidative stress inflammation.
Background and objectives: The bark of Alstonia boonei, known as stool wood, is sold in large quantities on the Ghanaian market. It used for treatment numerous ailments including snake bites, worm infestation, malaria rheumatic pains. For safety reasons, it necessary to control raw materials by setting simple but relevant parameters ensure identity, purity quality which have been aim present study authenticate plant materials. Methods: macroscopic, microscopic, physico-chemical,...
Potassium bromate (KBrO
Polyalthia longifolia (Sonn.) is a medicinal plant that belongs to the family Annonaceae, and it distributed in tropics. This widely grown West Africa for its ornamental purposes. There are two varieties of P. which commonly distinguishable by direction their branches. One has spreading perpendicular branches, other drooping pendulous Traditional herbal practitioners believe one variety (P. cv. pendula) more than other. study, therefore, sought investigate phytochemical components HPTLC,...
Quercetin reduces blood pressure in hypertensive, but not normotensive individuals. Ex vivo tissue has implicated NADPH oxidase signalling and ROS formation the mechanism of action vascular smooth muscle, however there been no assessment role endothelium anti-hypertensive effects quercetin. This study describes an endothelial cell model hypertension its use to probe Angiotensin II (100 nM, 8 h) rendered Human Umbilical Vein Endothelial Cells (HUVEC) characterised by decreased nitric oxide...
Investigating human platelet function in low-oxygen environments is important multiple settings, including hypobaric hypoxia (e.g., high altitude), sea level hypoxia-related disease, and thrombus stability. These studies often involve drawing blood from which platelets are isolated analysed at atmospheric conditions or re-exposed to low oxygen levels chambers before testing. However, it remains unknown how the vitro handling of samples itself changes their dissolved concentration, might...
Abstract Background and Aims Iron deficiency is commonly treated with intravenous (IV) iron where oral insufficient or cannot be tolerated. While IV considered efficient effective, safety concerns exist regarding the potential effect of on oxidative stress, inflammation endothelial function. Transferrin unable to saturate all administered. Consequently, evidence has suggested differential generation “free” catalytic labile iron, depending preparation. Labile stimulates lipid oxidation free...
PURPOSE: Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 α) is a and transcription factor involved in energy metabolism. The Gly482Ser variant (G1444A) of this gene has been associated with Type 2 diabetes (T2D) incidence some, but not all, previous studies. These mixed results are likely due to the presence co-morbidities T2D. Metabolic syndrome typically precedes development full blown T2D, denned as having abnormal threshold values for three five criteria...
The availability of reliable and fast analytical method is crucial for the quality control multi-API in a single dosage form. Herein, two methods have been developed validated determination Cyproheptadine hydrochloride (CH), Thiamine mononitrate (Vit. B 1 ), Calcium pantothenate 5 ) Pyridoxine 6 uncoated tablets. To assay vitamins, mobile phase combination Phosphate buffer pH 3.5 Methanol ratio 93:7, using Eurospher ODS (150 x 4.5mm) as stationary with flow rate set at 1.0 mL/min ambient...