A5063456004- Ethnobotanical and Medicinal Plants Studies
- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Synthesis and bioactivity of alkaloids
- Pharmaceutical Quality and Counterfeiting
- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Plant tissue culture and regeneration
- Natural Antidiabetic Agents Studies
- Pharmaceutical Economics and Policy
- Neurotransmitter Receptor Influence on Behavior
- Traditional and Medicinal Uses of Annonaceae
- Alkaloids: synthesis and pharmacology
- Medicinal Plants and Neuroprotection
- Biotechnology and Related Fields
- Malaria Research and Control
- Phytochemistry and Biological Activities
- Pain Mechanisms and Treatments
- Seed Germination and Physiology
- Herbal Medicine Research Studies
- Neuroscience and Neuropharmacology Research
- Chemical synthesis and alkaloids
- Trypanosoma species research and implications
- Cannabis and Cannabinoid Research
- Insect Pest Control Strategies
University of Ghana
2016-2025
Mental and neurological disorders are a serious public health challenge globally, particularly in developing countries where cultural factors limited access to standard healthcare have led reliance on traditional medicines. However, ethnopharmacological characterization of medicines used treat these diseases is lacking. In this study, an ethnobotanical description plant species treating mental Ghana update their experimentally validated pharmacological relevance provided.Two hundred...
This study, conducted as part of our overall goal regular pharmacovigilance antimalarial medicines, reports on the quality 132 artemisinin-based medicines distributed in Ghana and Togo. Three methods were employed evaluation—basic (colorimetric) tests for establishing identity requisite active pharmaceutical ingredients (APIs), semi-quantitative TLC assay identification estimation API content, HPLC a more accurate quantification content. From basic tests, only one sample totally lacked API....
Leishmania is a parasitic protozoon responsible for the neglected tropical disease Leishmaniasis. Approximately, 350 million people are susceptible and close to 70,000 death cases globally reported annually. The lack of effective leishmanicides, emergence drug resistance toxicity concerns necessitate pursuit antileishmanial drugs. Natural compounds serve as reservoirs discovering new drugs due their chemical diversity. Hardwickiic acid (HA) isolated from stembark Croton sylvaticus was...
This study presents the results of aflatoxin contamination maize and groundnuts in major markets Accra assesses population's exposure to aflatoxins. Raw from 6 were sampled analysed for their content. A total 92 samples comprising 48 44 using high-performance liquid chromatography, after extraction with methanol/water cleanup on an immunoaffinity column. Total aflatoxins quantified 98% 70% groundnut samples, concentrations ranging 0.60 1065 µg/kg 0.20 627 µg/kg, respectively. Exposure...
The growing concern over the extent of anti-malarial medicine resistance in sub-Saharan Africa, driven largely by administration sub-therapeutic doses derived from falsified and substandard medicines necessitates regular monitoring quality these to avert any potential public health disaster. This study aimed at determining active pharmaceutical ingredient (API) content available Malawi with respect manufacturers' label claim pharmacopoeia specifications.Samples (112) collected both licensed...
The hydro-ethanolic whole plant extract of Synedrella nodiflora (SNE) has demonstrated anticonvulsant, sedative and analgesic effects. Preliminary studies conducted in animals, SNE significantly decreased stereotypic behaviours suggesting antipsychotic potential. Coupled with the central nervous system depressant effects SNE, we hypothesized that it may have utility management psychosis. present study therefore investigated potential several murine models primary activities (30–3000 mg/kg,...
Dichapetalum filicaule Breteler (Dichapetalaceae) is a rare species occurring only in Côte d'Ivoire and Ghana. Although research on several of the genus has produced interesting bioactive compounds, particularly Dichapetalins, novel class triterpenoids with antineoplastic properties, there virtually no information ethnobotanical uses chemical constituents D. filicaule.The phytochemical anthelminthic activities were investigated.Chemical petroleum ether, chloroform-acetone, methanol root...
Abstract Mango farmers in Ghana are confronted with many pest problems like fruit flies, Sternochetus mangiferae (F.), and mealy bugs. Different management options available to mango farmers; however, the extent which they apply is not well known. A survey was conducted among 60 southeastern Ghana, from October–December 2015 season, find out level of knowledge practice insect used by farmers. The results showed that most use conventional insecticides control pests mango. Majority (30%) a...
Several flavonoids isolated from certain plants have demonstrated antiplasmodial activity, after their initial indigenous use in malaria treatment. Cocoa has been found to be a rich food source of comparison with many common foods and beverages. The aim this work was investigate the vitro activity natural cocoa powder on growth Plasmodium falciparum. Prepared crude methanol extract partitioned successively petroleum ether, ethyl acetate, chloroform, butanol. Total flavonoid concentration...
Synedrella nodiflora is used by traditional healers in Ghana for the management of epilepsy and pain. The hydro-ethanolic extract whole plant has demonstrated antinociceptive effect various animal models This study investigated potential benefit a rat model paclitaxel-induced neuropathic Neuropathy was induced rats continuous intraperitoneal administration paclitaxel (2 mg/kg) 5 days. Baseline latencies to thermal pain were recorded before first injection during day induction period....
Abstract Background : The hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn whole plant has demonstrated analgesic effects in acute pain models. also anticonvulsant murine models experimental epilepsy. present study illustrates an evaluation the for possible properties hyperalgesia and allodynia associated with vincristine-induced neuropathy rats. Methods Neuropathic was induced Sprague-Dawley rats by injecting 100 μg/kg vincristine sulphate on alternative days 6 (days 0, 2, 4, 8,...
As part of our search for bioactive compounds from the Dichapetalaceae, repeated chromatographic purification roots a hitherto unexamined species, Dichapetalum pallidum, led to isolation newly occurring 7-hydroxydichapetalin P (1) and known dichapetalins A (2) X (3). Also isolated were friedelin-2,3-lactone (4), friedelan-3-one (6), friedelan-3β-ol (7) pomolic (8), as well dipeptide aurantiamide acetate (5). The characterized by direct interpretation their IR, 1D NMR 2D spectral data...
Here we report a new polyhydroxylated triterpene, 2β,6β,21α-trihydroxyfriedelan-3-one (4) isolated from the root and stem bark of Dichapetalum albidum A. Chev (Dichapetalaceae), along with six known triterpenoids (1-3, 5, 6, 8), sitosterol-3β-O-D-glucopyranoside (9), dipeptide (7), tyramine derivative coumaric acid (10). Friedelan-3-one (2) showed an antimicrobial activity (IC50) 11.40 μg/mL against Bacillus cereus, while friedelan-3α-ol (1) gave IC50 13.07 Staphylococcus aureus ampicillin...
Phytochemical investigation of the ethanol extract whole plant Scoparia dulcis, has resulted in isolation 4, 5, 7-trihydroxy-6-methoxyflavone, commonly called hispidulin and a steroidal glycoside, β-sitosterol-β-D-glucoside. This is first two compounds from S. dulcis. Also isolated characterized were previously reported 6-me-thoxybenzoxazolinone, friedelan-3-one scopadulcic acid B. Structural elucidation was done on basis spectroscopic data interpretations (IR, UV, NMR EIMS). Using...
Dichapetalum crassifolium Chodat (Dichapetalaceae) is widely distributed in Africa, Tropical Asia and Latin America. As part of our quest for potential bioactive lead compounds various neglected tropical diseases, we report the anti-schistosomal crude extracts chemical constituents stems roots crassifolium. Column chromatography led to isolation identification three oleanane-type triterpenoids, friedelan-3β-ol (1), friedelan-3-one (2), maslinic acid (3); ursane-type tritepenoid, pomolic (4)...