Mental and neurological disorders are a serious public health challenge globally, particularly in developing countries where cultural factors limited access to standard healthcare have led reliance on traditional medicines. However, ethnopharmacological characterization of medicines used treat these diseases is lacking. In this study, an ethnobotanical description plant species treating mental Ghana update their experimentally validated pharmacological relevance provided.Two hundred...

Nymphaea lotus L. (N. lotus) is an aquatic plant with anecdotal reports suggesting its use in the traditional management of cancer. However, there a paucity data on antioxidant, anti-inflammatory and cytotoxic properties N. relation to phytochemical elemental contents. This study aimed at determining hydro-ethanolic extract leaves (NLE), phenolic, flavonoid constituents.The antioxidant property NLE was determined using total phenolic flavonoid, DPPH radical scavenging, lipid peroxidation...

ABSTRACT Purpose Gut microbiota is strongly linked to the activity of bidirectional gut‐brain axis, which influences neuropsychological processes at multiple levels. Changes in gut have been implicated mood disorders, and probiotics explored for their ability mitigate effects stress on mental health. Here, we investigated therapeutic benefits different concentrations combinations Lactobacillus Bifidobacterium a mouse model induced depression anxiety. Methods Sixty‐three male ICR mice (6–8...

The hydro-ethanolic whole plant extract of Synedrella nodiflora (SNE) has demonstrated anticonvulsant, sedative and analgesic effects. Preliminary studies conducted in animals, SNE significantly decreased stereotypic behaviours suggesting antipsychotic potential. Coupled with the central nervous system depressant effects SNE, we hypothesized that it may have utility management psychosis. present study therefore investigated potential several murine models primary activities (30–3000 mg/kg,...

Depression continues to be a major global health problem. Although antidepressants are used for its treatment, efficacy is often inconsistent. Thus, the search alternative therapeutic medicines treatment still important. In this study, antidepressant-like effect of Pseudospondias microcarpa extract (30-300 mg kg(-1), p.o.) was investigated in two predictive models depression--forced swimming test and tail suspension mice. Additionally, mechanism(s) action involved were assessed. Acute with...

Xylopic acid, a diterpenoid isolated from the fruits of Xylopia aethiopica has demonstrated analge-sic properties in acute pain models. It was therefore evaluated for its analgesic paclitaxel-induced neuropathic pain, type difficult to treat clinically. Neuropathic induced rats by injecting 2 mg kg-1 paclitaxel on alternative days four (days 0, 2, 4 and 6). Paclitaxel-induced cold allodynia, mechanical hyperalgesia thermal were measured during pre-paclitaxel administration day 16...

Context: Mallotus oppositifolius is a shrub that used traditionally to treat epilepsy, but its potential has not been scientifically validated. Aims: This study investigated the anticonvulsant properties and possible mechanism of action 70% v/v hydroalcoholic extract leaves M. oppositifolius. Materials Methods: Inprinting control region (ICR) mice (25–30 g) were pretreated with leaf (10–100 mg/kg) before administering respective convulsants (pentylenetetrazole [PTZ], picrotoxin [PTX],...

Synedrella nodiflora is used by traditional healers in Ghana for the management of epilepsy and pain. The hydro-ethanolic extract whole plant has demonstrated antinociceptive effect various animal models This study investigated potential benefit a rat model paclitaxel-induced neuropathic Neuropathy was induced rats continuous intraperitoneal administration paclitaxel (2 mg/kg) 5 days. Baseline latencies to thermal pain were recorded before first injection during day induction period....

Objective . Hydroalcoholic extract of leaves Mallotus oppositifolius (MOE), a plant used for CNS conditions in Ghana, was investigated acute antidepressant effects the forced swimming (FST) and tail suspension tests (TST). Results In both FST TST, MOE (10, 30, 100 mg kg −1 ) significantly decreased immobility periods frequencies. A 3-day pretreatment with 200 , i.p., para-chlorophenylalanine (PCPA), tryptophan hydroxylase inhibitor, reversed decline increase score induced by modified FST....

Pseudospondias microcarpa (Anacardiaceae) is a plant widely used traditionally for treating various central nervous system disorders. A previous study in our laboratory confirmed that the hydroethanolic leaf extract (PME) of produces an antidepressant-like effect rodent models behavioral despair. However, its on depressive-like behavior induced by chronic mild stress (CMS) and time course action are still unknown. In this context, long-term effects PME cognitive function depressive-...

Antiaris toxicaria (Moraceae) was evaluated for anticonvulsant activity in rodents. Animal models used include maximal electroshock test (MEST); pentylenetetrazole-induced (PTZ) convulsions; picrotoxin-induced (PCT) strychnine- (STR-) and 4-aminopyridine-induced convulsions. Increase latency to seizures as well reduction duration frequency of indicated activity. The extract more effective all except the strychnine-induced aqueous (200, 400, 800 mg kg(-1)) significantly (P < 0.05 - 0.01)...

Context: Kalanchoe sp. have been used since 1921 for central nervous system (CNS) disorders such as psychosis and depression. It is known to possess CNS depressant effects. Aims: To investigate the antidepressant properties of aqueous leaf extract integra. Settings Design: The study was carried out at Kwame Nkrumah University Science Technology between 6 a.m. 3 p.m. Materials Methods: ICR mice were subjected forced swimming test (FST) tail suspension (TST) after they had received (30-300...

There is considerable evidence that many people take dietary supplements including those of herbal origin as an alternative therapy to improve their health. One such supplement, with amalgam constituents, CellGevity®. However, the effect this supplement on drug-metabolizing enzymes poorly understood, it has not been studied extensively. Therefore, we investigated CellGevity selected rat liver microsomal cytochrome P450 (CYP) enzymes, most common enzymes. We also determined total antioxidant...

Cognitive dysfunction, presenting as learning and memory impairment, is a common manifestation in many chronic diseases of the nervous system. Some these include depression, epilepsy, Alzheimer's disease. To date, few drugs or medicinal products have shown ability to improve deficits. Neuroprotection one mechanisms by which could be improved. The extract Xylopia aethiopica its kaurene derivative, xylopic acid, previously demonstrated neuroprotective effects animal models. aim present study...

Postpartum depression is a mood disorder that affects about 9-20% of women after child birth. Reports suggest gestational iron deficiency can cause deficit in behavioral, cognitive and affective functions precipitate depressive symptoms mothers during the postpartum period. The present study examined effect supplementation on behavior period rat model.Female Sprague-Dawley rats were crossed. Pregnant received iron, fluoxetine, desferrioxamine or vehicle throughout gestation. During period,...

Background/Aim: Depression-related aggression is linked to serotonin (5-HT) and dendritic spine alterations. Although Mallotus oppositifolius extract (MOE) has potential for reducing this effect, its specific role remains uncertain. Herein, we evaluated associated alterations in the brain. Methods: A standard resident-intruder model of para-chlorophenylalanine (pCPA)-induced depression-associated male ICR mice was used. The resident received pCPA (300 mg/kg, i. p.) 3 consecutive days while...

Trichilia monadelpha is a common medicinal plant used traditionally in treating central nervous system conditions such as epilepsy, depression, pain, and psychosis. In this study, the antidepressant-like effect of crude extracts stem bark T. was investigated using two classical murine models, forced swimming test (FST) tail suspension (TST). The extracts, petroleum ether, ethyl acetate, hydroethanolic (30-300 mg/kg, p.o.), standard drug (imipramine; fluoxetine, 3-30 saline (vehicle) were...

Pseudospondias microcarpa (Anacardiaceae), the African grape tree, is used for various CNS disorders. The neuropharmacological activities of hydroethanolic leaf extract (PME) were screened in mice. In this study, central nervous system (CNS) activity was tested animal models including Irwin test, pentobarbitone-induced sleeping time, spontaneous motor activity, rotarod pentylenetetrazole-induced convulsions and tail immersion test. produced sedation analgesia test with an LD50 above 3000 mg...

Natural polymer research has recently become the focus of intensive in quest for new enabling excipients novel drugs pharmaceutical formulation optimal treatment outcomes. Evaluations some have shown deleterious haematological effects varying extents on safety profile these excipients. A 90-day subchronic toxicity study was conducted to evaluate influence cocoa pod husk (CPH) pectin indicators haematotoxicity. Male and female Sprague Dawley rats (SDRs) were fed with CPH doses up 71.4 mg/kg....