A5011038225- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Thyroid Disorders and Treatments
- Machine Learning in Healthcare
- BRCA gene mutations in cancer
- Neuroendocrine Tumor Research Advances
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Artificial Intelligence in Healthcare
- Diabetes Management and Research
- Patient-Provider Communication in Healthcare
- Data Mining Algorithms and Applications
- Lipoproteins and Cardiovascular Health
- Cardiac Ischemia and Reperfusion
- Growth Hormone and Insulin-like Growth Factors
- Biomedical Text Mining and Ontologies
- Radiopharmaceutical Chemistry and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Vitamin K Research Studies
- Clinical Reasoning and Diagnostic Skills
- Diabetes Management and Education
- Estrogen and related hormone effects
- Chronic Disease Management Strategies
- Lipid metabolism and disorders
Mayo Clinic
2015-2024
WinnMed
2015-2024
Mayo Clinic in Arizona
2015-2024
University of Minnesota System
2021
University of Puerto Rico System
2014-2015
Institute of Nutrition, Metabolism and Diabetes
2008
Allergan (United States)
2005
Albany Stratton VA Medical Center Albany
2003
University at Albany, State University of New York
2002
New York/New Jersey VA Health Care Network
2002
Molecular markers hold the promise of improved diagnostic yield in thyroid fine-needle biopsy. The Afirma gene expression classifier (GEC), available commercially, reports a negative predictive value 94% diagnosis benign nodules after indeterminate cytology. However, there are currently no independent studies performance this assay.The aim was to assess GEC an academic medical center.Samples for were collected according manufacturer's recommended protocol from patients undergoing aspiration....
Background: Approximately 15% more patients taking levothyroxine (LT4) report impaired quality of life compared to controls. This could be explained by additional diagnoses independently affecting and complicating assignment causation. study sought investigate the underpinnings reduced in hypothyroid provide data for discussion at a symposium addressing hypothyroidism. Methods: An online survey was posted on American Thyroid Association Web site forwarded multiple groups. Respondents were...
Measurement of thyroglobulin (Tg) by mass spectrometry (Tg-MS) is emerging as a tool for accurate Tg quantification in patients with anti-Tg autoantibodies (TgAbs). The objective the study was to perform analytical and clinical evaluations two Tg-MS assays comparison immunometric (Tg-IAs) RIAs (Tg-RIAs) cohort thyroid cancer patients. A total 589 samples from 495 patients, 243 TgAb−/252 TgAb+, were tested Beckman, Roche, Siemens-Immulite, Thermo-Brahms TgAb assays, Tg-RIAs, assays. frequency...
<h3>Background</h3> Vitamin K participates in bone metabolism and, since oral anticoagulants antagonize vitamin K, their use may increase the risk of osteoporosis. <h3>Objective</h3> To evaluate fracture at all skeletal sites following exposure to anticoagulants. <h3>Methods</h3> In a population-based retrospective cohort study, 572 Olmsted County, Minnesota, women 35 years or older first lifetime venous thromboembolism event between 1966 and 1990 were followed up for fractures. Risk was...
Background: Fine needle aspiration (FNA), although very reliable for cytologically benign and malignant thyroid nodules, has much lower predictive value in the case of suspicious or indeterminate nodules. We aimed to identify clinical predictors malignancy subset patients with FNA cytology. Methods: reviewed electronic medical records 462 who had nodules at our institution a cytological diagnosis, underwent surgery Mayo Clinic between January 2004 September 2008. Demographic data including...
Thyroid-stimulating hormone (TSH)-secreting pituitary adenomas are rare, representing < 2% of all adenomas.The authors conducted a retrospective analysis patients with TSH-secreting or clinically silent TSH-immunostaining tumors among followed at their institution between 1987 and 2003. Patient records, including clinical, imaging, pathological surgical characteristics were reviewed. Twenty-one (6 women 15 men; mean age 46 years, range 26-73 years) identified. Of these, 10 had history...
Disease progression models, statistical models that assess a patient's risk of diabetes progression, are popular tools in clinical practice for prevention and management chronic conditions. Most, if not all, currently use based on gold standard trial data. The relatively small sample size available from limits these only considering the state at time assessment ignoring trajectory, sequence events, led up to state. Recent advances adoption electronic health record (EHR) systems large they...
Early detection of patients with elevated risk developing diabetes mellitus is critical to the improved prevention and overall clinical management these patients. We aim apply association rule mining electronic medical records (EMR) discover sets factors their corresponding subpopulations that represent at particularly high diabetes. Given dimensionality EMRs, generates a very large set rules which we need summarize for easy use. reviewed four summarization techniques conducted comparative...
Medullary thyroid cancer (MTC) can be associated with significant morbidity and mortality in advanced cases. Hence, we aimed to identify factors at the time of MTC surgery that predict overall survival (OS), disease-specific (DSS), locoregional recurrence/persistence (LR), distant metastases (DM).
Thyroid nodule treatment has significantly evolved over recent years with attempts to individualize on the basis of cause and patient performance status. The risks complications associated surgery radioactive iodine have promoted interest in additional therapies such as radiofrequency ablation (RFA). RFA creates an electrical current through a target tissue (thyroid nodule) resultant heating causing coagulative necrosis. National international groups are beginning recognize role viable...
Diabetes mellitus (DM) é uma doença crônica caracterizada por um estado hiperglicêmico. As formas mais prevalentes do DM são tipos 1 e 2. Essa constitui desafio significativo para a saúde global, com crescentes taxas de incidência morbimortalidade. A hiperglicemia compromete os vasos sanguíneos, levando danos celulares, alterações fisiológicas metabólicas, problemas funcionais, estruturais e/ou falência diversos órgãos. Ademais, o também está associado comprometimento sistema imunológico,...
The ability of thyroid cancers to concentrate radioiodine (RAI) is dependent, in part, upon the expression and functional integrity sodium iodide symporter (NIS). However, some differentiated carcinomas (DTCs) most undifferentiated lack are thereby insensitive 131I therapy. Variation NIS protein may be an important factor this behavior. We wished determine whether primary DTC tumors correlated with subsequent RAI uptake by metastatic lesions same patients. obtained paraffin-embedded tissue...
The best treatment option for patients with Graves' disease (GD) depends on each person's situation and how the differences between options matter to them in bringing resolution their illness. objective of this study was develop test an encounter decision tool (GD Choice) clinicians engage shared making about GD.GD Choice developed using iterative process based principles interaction design participatory action research. To evaluate impact tool, a controlled before-after conducted, assessing...
Fine-needle aspiration (FNA) of thyroid nodules is commonly performed, and despite the use ultrasound (US) guidance, rate non-diagnostic FNAs still significant. The risk malignancy with a FNA not clearly defined. However, most studies exclude majority patients without repeat biopsy or surgery, thus increasing likelihood selection bias. aims this study were to determine in an initial FNA, identify factors associated malignancy.This was retrospective cohort who underwent US-guided between 2004...
Background: Levothyroxine (LT4) is the mainstay of therapy for hypothyroidism. Yet, despite physician efforts at dose titration, some patients remain hypothyroid on LT4 doses in excess weight-based calculations, a condition known as refractory The absorption test (LT4AT) has been proposed to have utility these by enabling distinction malabsorption from pseudomalabsorption, intentional nonadherence. Given its rare use clinical practice, we reviewed our institution's experience with LT4AT...