A5049947563- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Tea Polyphenols and Effects
- Protein Structure and Dynamics
Changchun University of Science and Technology
2024
Jilin University
2023
γ-secretase is an intramembrane proteolytic enzyme that mainly involved in the cleavage and hydrolysis of amyloid precursor (APP). The catalytic subunit presenilin 1 (PS1) γ-secretase. Since it was found PS1 responsible for Aβ-producing activity, which Alzheimer's disease, believed reducing activity preventing or delaying production Aβ could help treat disease. Consequently, recent years, researchers have begun investigating potential clinical efficacy inhibitors. Currently, most inhibitors...
The accumulation of cross-β-sheet amyloid fibrils is a hallmark the neurodegenerative process Alzheimer's disease (AD). Although it has been reported that green tea substances such as epicatechin (EC), epicatechin-3-gallate (ECG), epigallocatechin (EGC) and epigallocatechin-3-gallate (EGCG) could alleviate symptoms AD other diseases, pharmacological mechanism remains largely unexplored. This study aimed to reveal underlying EC, ECG, EGC EGCG in using computer-aided screening strategy. Our...
Abstract Alzheimer's disease (AD) presents a significant challenge in neurodegenerative management, with limited therapeutic options available for its prevention and treatment. At the heart of AD pathogenesis is amyloid-β (Aβ) protein precursor (APP), interaction between APP adaptor Mint2 being crucial. Despite previous explorations into APP-Mint2 interaction, dynamic regulatory mechanisms by which modulates binding remain poorly understood. This study undertakes molecular dynamics...