A5103192340- Natural product bioactivities and synthesis
- Immune Response and Inflammation
- Medicinal Plant Pharmacodynamics Research
- Animal Nutrition and Physiology
- Polysaccharides and Plant Cell Walls
- Sesquiterpenes and Asteraceae Studies
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Peptides and Activities
- Phytochemical compounds biological activities
- Peptidase Inhibition and Analysis
- Tryptophan and brain disorders
- Aquaculture disease management and microbiota
- Pharmacological Effects of Natural Compounds
- Microbial infections and disease research
- Herbal Medicine Research Studies
- Neuropeptides and Animal Physiology
- Phytochemistry and Biological Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Rabbits: Nutrition, Reproduction, Health
- Psoriasis: Treatment and Pathogenesis
- Agriculture, Plant Science, Crop Management
- Migraine and Headache Studies
- X-ray Diffraction in Crystallography
- Monoclonal and Polyclonal Antibodies Research
- Phytochemistry and Bioactive Compounds
Wroclaw University of Environmental and Life Sciences
2011-2024
Betulinic acid is a pentacyclic triterpene found in many plant species, among others, the bark of white birch Betula alba. was reported to display wide range biological effects, including antiviral, antiparasitic, antibacterial, anticancer and anti-inflammatory activities. The effects betulinic (50, 5, 0.5 mg/kg) administered orally five times at 24 hours intervals non-immunized red blood cells (SRBC)-immunized mice were determined. present study examined total number lymphocytes thymus,...
Florfenicol is a broad-spectrum bacteriostatic antibiotic used in domestic animals. The aim of the study was to determine effect florfenicol on total number lymphocytes thymus, spleen and mesenteric lymph nodes percentage absolute T cell subsets (CD4+CD8+, CD4-CD8-, CD4+, CD8+) thymus (CD3+, B (CD19+) peripheral lymphatic organs non-immunized mice humoral immune response sheep red blood cells (SRBC)-immunized mice. administered orally at dose 30 mg/kg six times 24 h intervals four or seven...
The effects of in ovo-delivered prebiotics and synbiotics on the lymphocyte subsets lymphoid organs non-immunized 7-day-old broiler chickens non-immunized, sheep red blood cells (SRBC)-immunized, dextran (DEX)-immunized 21- 35-day-old birds were studied. substances injected 12th day egg incubation: Prebiotic1 group (Pre1) with a solution inulin, Prebiotic2 (Pre2) Bi2tos (non-digestive transgalacto-oligosaccharides), Synbiotic1 (Syn1) inulin Lactococcus lactis subsp. IBB SL1, Synbiotic2...
1. The aim of this study was to determine if the pharmacokinetics (PK) florfenicol (FF) undergo age-dependent changes in broilers. Since drug elimination depends on cardiovascular functions, a haemodynamic performed parallel. 2. Broilers 0.68, 1.27, 2.45 and 5.13 kg were administered FF single intravenous dose 30 mg/kg body weight. Plasma concentrations determined using high-performance liquid chromatography PK parameters calculated non-compartmental model. Echocardiography used measure...
This study investigated the effect of hawthorn (Crataegus monogyna) phenolic extract on lymphocyte subsets in lymphoid organs nonimmunized mice and humoral immune response sheep red blood cell-immunized mice. Hawthorn (50, 100, 200 mg/kg) was administered orally five or ten times. Sheep cells were injected 24 h after administration last dose. The assessed 72 Humoral determined 4 7 days immunization. Five doses decreased percentage CD4-CD8- CD4+ thymocytes but elevated CD4+CD8+ CD8+ thymic...
The effects of bestatin on humoral immune response to sheep erythrocytes (SRBC) and restoration the impaired by a single cyclophosphamide dose (350 mg/kg) were tested mice. Bestatin (at doses 10, 1, 0.1 was administered intraperitoneally (i.p.) 5 or 10 times. pharmacological immunosuppression induced i.p. injection 24 h before first dose. mice immunized with SRBC after last bestatin. It found that multiple administration at all three potentiated in non-treated mice, resulting an increased...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Lis M, Obmińska-Mrukowicz B. Experimental immunologyModulatory effects of bestatin on T and B lymphocyte subsets the concentration cytokines released by Th1/Th2 lymphocytes in cyclophosphamide-treated mice. Central European Journal Immunology. 2013;38(1):42-53. doi:10.5114/ceji.2013.34357. APA Lis, M., & Obmińska-Mrukowicz, (2013). Immunology, 38(1), 42-53. https://doi.org/10.5114/ceji.2013.34357 Chicago...
Bestatin, a low-molecular weight dipeptide, is potent inhibitor of aminopeptidase N which has been demonstrated to have antitumor and immunomodulatory effects. The effects bestatin (10, 1 0.1 mg/kg) administered intraperitoneally once, five or ten times mice on the total number lymphocytes in thymus, spleen mesenteric lymph nodes percentage absolute T cell subsets (CD4+CD8+, CD4-CD8-, CD4+, CD8+) thymus (CD3+, B (CD19+) were studied. It found that at doses 10, mg/kg increased thymocytes,...
Abstract Objectives The aim of the study was to investigate immunomodulatory effect in-vivo administered propentofylline on subsets and activity murine lymphocytes. Methods Propentofylline (3 mg/kg) orally 8-week-old Balb/c mice, once or six times at 12-h intervals. lymphocyte subsets, regulatory T cells, IL-5 TNF levels were determined 12 h 24 after a single dose sixth drug in non-immunized mice. Humoral immune response sheep red blood cells (SRBC)-immunized mice 4, 7 14 days immunization....
Yolkin is a polypeptide complex isolated from hen egg yolk that exhibits immunomodulating properties. The aim of the present study was to determine whether in-ovo-delivered yolkin affects leukocyte populations and cytokine levels in broiler chickens. experiment carried out on eggs Ross 308 breeder birds. administered ovo 18th day incubation, once, at following three doses: 1, 10, or 100 µg/egg. immunological parameters were assessed 1-, 7-, 14-, 21-, 28-, 35-, 42-day-old birds kept under...
Abstract Objectives Our aim was to find out whether clomipramine, a tricyclic antidepressant, and selegiline, monoamine oxidase-B inhibitor, influence the activity of phagocytic cells after in-vivo administration in mice. Methods Clomipramine selegiline were administered Balb/c mice orally at dose 1 mg/kg, 7 or 14 times. IL-1β nitric oxide (NO) levels measured supernatants peritoneal macrophage cultures stimulated vitro with lipopolysaccharide from Escherichia coli. The granulocytes...
Yolkin, an egg yolk immunoregulatory protein, stimulates the humoral but inhibits cellular immune response in adult mice. The aim of this investigation was to evaluate effects yolkin administration on using a model juvenile, i.e., 28-day- and 37-day-old, We examined influence magnitude response, which determined as contact sensitivity (CS) oxazolone (OXA), antibody ovalbumin (OVA). Yolkin administered drinking water, followed by immunization with OXA or OVA. In parallel, phenotypic changes...
A series of epoxyesters were lactonized by HClO4 to give corresponding ς-hydroxy-γ-lactones as a mixture diastereoisomers: trans and cis. The mixtures products separated via column chromatography. lactones synthesized screened for anticancer activity against D17 U2-OS cell lines. Only the isomer with naphthyl ring was found exhibit significant both Keywords: Lactones, epoxyesters, aromatic ring, diastereoisomers, hydroxlactonization, antiproliferative activity.
AMA Suszko A, Szczypka M, Lis Kuduk-Jaworska J, Obmińska-Mrukowicz B. Experimental immunologyInfluence of polysaccharide fraction C isolated from Caltha palustris L. on T and B lymphocyte subsets in mice. Central European Journal Immunology. 2012;37(3):193-199. doi:10.5114/ceji.2012.30792. APA Suszko, A., Szczypka, M., Lis, Kuduk-Jaworska, J., & Obmińska-Mrukowicz, (2012). Immunology, 37(3), 193-199. https://doi.org/10.5114/ceji.2012.30792 Chicago Agnieszka, Marianna Magdalena Janina Bożena...
Context: Leaf extracts of plants the genus Betula have traditionally been used as diuretic, anti-rheumatic and diaphoretic preparations. One main active ingredients bark is betulin, lupane-type triterpene alcohol, with multiple biological activities.Objectives: The aim this study was to investigate in vitro vivo immunomodulatory effects a newly synthesized ester betulin: 28-O-phosphatidylbetulin [28-O-(1,2-diacyl-sn-glycero-3-phospho)-betulin, DAPB] comparison betulin mice.Materials methods:...
Florfenicol is a broad-spectrum bacteriostatic antibiotic commonly used for the treatment of systemic infections in farm animals.The aim this study was to determine effect florfenicol on percentage T lymphocytes (CD3 + , CD4 CD8 TCRgd cells) and B (Bu-1 total serum anti -sheep red blood cell (SRBC) haemagglutinin titer peripheral SRBC-immunized broiler chickens.The included three groups chickens differentiated by weight (0.5, 1.2, 2.4 kg).Florfenicol administered orally at dose 30 mg/kg.The...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Suszko A, Szczypka M, Lis Kuduk-Jaworska J, Obmińska-Mrukowicz B. Experimental immunologyModulation of murine T and B lymphocyte subsets by polysaccharide fraction isolated from Caltha palustris L. Central European Journal Immunology. 2013;38(2):175-182. doi:10.5114/ceji.2013.35212. APA Suszko, A., Szczypka, M., Lis, Kuduk-Jaworska, J., & Obmińska-Mrukowicz, (2013). Immunology, 38(2), 175-182....
AMA Szczypka M, Lis Suszko A, Pawlak Obmińska-Mrukowicz B. Experimental immunologyThe activity of phagocytic cells after in vivo administration propentofylline mice. Central European Journal Immunology. 2013;38(2):169-174. doi:10.5114/ceji.2013.35210. APA Szczypka, M., Lis, Suszko, A., Pawlak, & Obmińska-Mrukowicz, (2013). Immunology, 38(2), 169-174. https://doi.org/10.5114/ceji.2013.35210 Chicago Marianna, Magdalena Agnieszka Aleksandra and Bożena Obmińska-Mrukowicz. 2013. "Experimental...