A5078266878- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Growth Hormone and Insulin-like Growth Factors
- Estrogen and related hormone effects
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Endometriosis Research and Treatment
- Neuropeptides and Animal Physiology
- Uterine Myomas and Treatments
- TGF-β signaling in diseases
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Endometrial and Cervical Cancer Treatments
- Sexual Differentiation and Disorders
- Hormonal Regulation and Hypertension
- Thyroid Disorders and Treatments
- Menopause: Health Impacts and Treatments
- Epigenetics and DNA Methylation
- Health and Medical Research Impacts
- Ovarian cancer diagnosis and treatment
- Intestinal and Peritoneal Adhesions
- Reproductive Health and Contraception
- Genetic Syndromes and Imprinting
- Gynecological conditions and treatments
Bayer (United States)
2022-2024
National Institutes of Health
2018-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2010-2024
Eunice Kennedy Shriver Center
2020-2022
The University of Texas Southwestern Medical Center
2003-2013
Southwestern Medical Center
2007-2008
Texas Medical Center
2007
Tufts Medical Center
1994-2003
Brigham and Women's Hospital
1996-2003
Tufts University
1996-2000
To estimate the possibility of long-term effects subclinical thyroid dysfunction on hypertension and other cardiovascular-related conditions during pregnancy.This is a secondary analysis prospective prenatal population-based study in which serum thyroid-function analytes were measured from November 2000 through April 2003. Women with evidence overt disease excluded. The remaining women classified as being euthyroid, having hyperthyroid, or hypothyroid, frequency pregnancy-associated...
To estimate the prevalence of antithyroid peroxidase antibodies in general obstetric population and to compare pregnancy outcomes women who are peroxidase-antibody positive with those negative.Between November 2000 April 2003, all presented for prenatal care underwent thyroid screening. Serum samples from without clinical hypothyroidism had been screened first 20 weeks gestation delivered a singleton newborn weighing 500 g or more were analyzed concentrations antibodies. antibody levels...
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Recent <i>in vivo</i> and vitro</i> studies have implicated the orphan nuclear receptor, steroidogenic factor-1 (SF-1), early growth response protein 1 (Egr-1) in transcriptional regulation of luteinizing hormone β-subunit (LHβ) gene. We previously demonstrated ability SF-1 to bind transactivate rat LHβ gene promoter acting at a consensus gonadotrope-specific element (GSE) located position −127. now identified second functional GSE site −59. In addition, based on electrophoretic mobility...
Recently, several cis-regulatory elements that play roles in LHβ gene expression, and their cognate DNA-binding transcription factors, have been identified. These factors include Sp1, steroidogenic factor-1 (SF-1), early growth response protein 1 (Egr-1). Using the GH3 pituitary cell line (which lacks SF-1) as a model, we demonstrate expression of SF-1 or Egr-1 increases rat promoter activity but has little effect on fold to GnRH. However, both synergistically enhances prevents further...
Journal Article Transcriptional activation of the follicle-stimulating hormone beta-subunit gene by activin Get access J Weiss, Weiss 1Department Medicine, Northwestern University, Chicago 60611, USA. Search for other works this author on: Oxford Academic Google Scholar M Guendner, Guendner L Halvorson, Halvorson Jameson Endocrinology, Volume 136, Issue 5, 1 May 1995, Pages 1885–1891, https://doi.org/10.1210/endo.136.5.7720634 Published: 01 1995
Abstract Expression of the LHβ gene has been shown to be modulated by both orphan nuclear receptor, steroidogenic factor-1 (SF-1), and early growth response protein 1, Egr-1. It is also well known that mRNA levels are increased after hormonal activation kinase C (PKC) signaling system, for example GnRH; however, mechanisms which PKC system exerts this effect not fully characterized. By transient transfection GH3 cell line, we demonstrate with phorbol ester, 12-myristate 13-acetate (PMA),...
Gonadotropin biosynthesis and secretion are influenced by pulsatile GnRH derived from the hypothalamus as well paracrine factors. In current studies, we compared effects of inhibin, activin, GnRH, alone in combination, on gonadotropin subunit messenger RNA (mRNA) levels secretion. A pituitary perifusion system was used to allow be administered pulses minimize effects. FSH beta mRNA were increased 25-fold a maximal concentration activin (3 ng/ml) suppressed 83% inhibin (30 ng/ml). When...
FSH synthesis and secretion are regulated by a complex interplay of hypothalamic, gonadal, pituitary factors. Recent evidence suggests that inhibin, activin, follistatin, although originally identified as gonadal peptides, also expressed in the pituitary, where they may be secreted play an autocrine/paracrine role control beta gene expression. Attempts to study regulation genes encoding these proteins have been hampered low levels mRNA Consequently, we developed quantitative reverse...
Journal Article Dynamic regulation of follicle-stimulating hormone-beta messenger ribonucleic acid levels by activin and gonadotropin-releasing hormone in perifused rat pituitary cells Get access J Weiss, Weiss 1Department Medicine, Massachusetts General Hospital, Boston 02114. Search for other works this author on: Oxford Academic Google Scholar P E Harris, Harris L M Halvorson, Halvorson W F Crowley, Jr, Jr Jameson Endocrinology, Volume 131, Issue 3, 1 September 1992, Pages 1403–1408,...
Recent studies have demonstrated a clear role for pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of gonadotropin biosynthesis and secretion, both alone conjunction with GnRH. First defined as hypothalamic releasing factor, PACAP subsequently has been identified gonadotrope subpopulation anterior gland, suggesting that may act an autocrine-paracrine factor this tissue. In initial studies, we determined GnRH markedly stimulated endogenous mRNA levels...
The GATA family of transcription factors are critical determinants cell differentiation as well regulation adult gene expression throughout the reproductive axis. Within anterior pituitary gland, have been shown to increase glycoprotein α-subunit promoter activity; however, nothing has known about impact these on gonadotropin β-subunits. In this study, we demonstrate both GATA2 and GATA4 in primary mouse gonadotropes gonadotrope line, LβT2. Based transient transfection fibroblast cells, LH...
Although reproductive aging in women is classically attributed to loss of ovarian follicles, recent data have suggested that the entire hypothalamic-pituitary-ovarian axis undergoes functional changes with time. The aim this study was characterize age-related pituitary gene expression for factors known importance gonadotroph function, including 1) steroid hormone receptors (Esr and Pgr), 2) orphan nuclear [Nr5a1 (steroidogenic factor-1) Nr5a2 (liver receptor homologue-1)], 3)...