A5060069912- Vasculitis and related conditions
- Urticaria and Related Conditions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Inflammatory mediators and NSAID effects
- Otitis Media and Relapsing Polychondritis
- Pain Mechanisms and Treatments
- Autoimmune Bullous Skin Diseases
- Renal Diseases and Glomerulopathies
University of British Columbia
2018-2024
Research Canada
2019
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic; OMIM #301054) syndrome is an autoinflammatory condition first described in November 2020.<sup>1</sup> It characterized by vacuoles myeloid and erythroid precursor cells on bone marrow biopsy caused a monogenic somatic mutation the ubiquitin-like modifier activating enzyme 1 (<i>UBA1</i>) gene.<sup>1,2</sup>
<h3>Background:</h3> Cutaneous polyarteritis nodosa (CPAN) is a small-to-medium vessel vasculitis limited to the skin. As it rare condition, there little data available guide treatment. Previous articles have suggested that colchicine and dapsone be used in mild disease glucocorticoids acute flares, with DMARDs such as methotrexate or azathioprine being reserved for moderate severe disease, steroid-refractory disease. <h3>Objectives:</h3> Our objective was review therapeutic regimens treat...