Signe Janum Eskildsen

ORCID: 0000-0003-2833-2114
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About
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Research Areas
  • Tracheal and airway disorders
  • Dysphagia Assessment and Management
  • Traumatic Brain Injury Research
  • RNA Research and Splicing
  • interferon and immune responses
  • Cardiac Arrest and Resuscitation
  • Esophageal and GI Pathology
  • Intensive Care Unit Cognitive Disorders
  • Cytokine Signaling Pathways and Interactions
  • Long-Term Effects of COVID-19
  • Family and Patient Care in Intensive Care Units
  • Child Nutrition and Feeding Issues
  • Head and Neck Cancer Studies
  • Oral health in cancer treatment
  • Stroke Rehabilitation and Recovery
  • Cardiac Health and Mental Health
  • Airway Management and Intubation Techniques

Copenhagen University Hospital
2019-2024

Rigshospitalet
2019-2024

Aarhus University
2002-2024

University of Copenhagen
2021

The interferon-induced 2'-5'-oligoadenylate synthetases (OAS) are important for the antiviral activity of interferons. human and murine OAS gene families each contain four genes: OAS1, OAS2, OAS3 OASL, all having one or more conserved units composed five translated exons. OASL has both an unit a C-terminus two ubiquitin-like repeats. In this study, we demonstrate that Oasl1 protein is inactive while Oasl2 active as OAS. Further more, requires double-stranded RNA co-factor. affinity activator...

10.1093/nar/gkg427 article EN Nucleic Acids Research 2003-06-11

Abstract The diagnosis and treatment of head neck cancer (HNC) can have substantial impact on swallowing function, nutritional balance, physical function quality life (QoL). Early initiated exercises are hypothesized to improve in HNC patients. aim was investigate the effects progressive resistance training (PRT) during radiotherapy QoL patients with pharynx-, larynx-, oral cavity or unknown primary compared usual care. In a multi-centre RCT participants were assigned (a) twice-weekly PRT...

10.1007/s00455-021-10320-5 article EN cc-by Dysphagia 2021-06-11

<h3>BACKGROUND:</h3> Prolonged tracheal tube placement following severe traumatic brain injury (TBI) can cause serious complications. Safe removal requires sufficient ability for independent breathing and airway protection. Thus, identifying important factors time to of the (decannulation) is essential safe efficient weaning. This study aimed identify significant decannulation in a Danish population subjects with tracheostomy after TBI. <h3>METHODS:</h3> was retrospective register-based...

10.4187/respcare.11376 article EN Respiratory Care 2024-04-22

Introduction Dysphagia is a common and critical consequence of acquired brain injury (ABI) can cause severe complications. rehabilitation transforming from mainly compensatory strategies to the retraining swallowing function using principles neuroscience. However, there are no studies that map interventions available retrain in patients with moderate-to-severe ABI. Objective To systematically accessible research literature answer question: Which non-surgical, non-pharmacological used...

10.1136/bmjopen-2021-053244 article EN cc-by-nc BMJ Open 2021-12-01

Patient-reported return-to-work and job functioning 6 12 months after hospital discharge received rehabilitation interventions unmet needs were explored in a consecutive population of out-of-hospital cardiac arrest survivors. Patients working prior to invited participate telephone administered survey. Thirty-eight surveys conducted included for analysis, equivalent minimum response rate 95%. Survivors had extensive challenges returning work. Six- 12-months post-arrest, 58% 45% respectively...

10.1093/eurjcn/zvac039 article EN European Journal of Cardiovascular Nursing 2022-04-15

Multidisciplinary rehabilitation including occupational therapy after COVID-19 is recommended. However, evidence on how affects the ability to perform activities of daily living (ADL) sparse.The aim this study was explore ADL and cognitive status in patients with at time discharge three months postdischarge.This prospective multiple case included adults COVID-19, who had decreased performance compared habitual functional level. Data collection Assessment Motor Process Skills (AMPS) Montreal...

10.1155/2022/4605989 article EN cc-by Occupational Therapy International 2022-03-29

Objective To establish a generally accepted Danish definition of dysphagia to enhance collaboration across sectors and professions.Methods The study was initiated by multi-professional group experienced researchers board members the Society for Dysphagia. We used modified Delphi methodology achieve consensus among health care professionals from different professions contexts. initial stage consisted literature search leading draft definitions followed two rounds between stakeholder...

10.1080/00365521.2022.2151850 article EN cc-by-nc-nd Scandinavian Journal of Gastroenterology 2022-12-07

An individuals' ability to perform basic activities of daily living (ADL) is said be one the strongest predictors performance and independent within community. The Assessment Motor Process Skills (AMPS) tool was designed assess global functional level during ADL by investigating motor process skills. purpose this study skills in a consecutive cohort adult survivors out-of-hospital cardiac arrest at time discharge from hospital.This cross-sectional uses data prospective admitted Copenhagen...

10.1093/eurjcn/zvab020 article EN European Journal of Cardiovascular Nursing 2021-03-01
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